6PAY

Structure of HsICDH1:Mg(II):ICT:NADPH(50%) complex reveals structural basis for observation of half-sites reactivity

Summary for 6PAY

Entry DOI	10.2210/pdb6pay/pdb
Descriptor	Isocitrate dehydrogenase [NADP] cytoplasmic, ISOCITRIC ACID, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	substrate complex, half-sites reactivity, icdh mechanism, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	188814.20
Authors	Silvaggi, N.R.,Melkonian, T.R.,Roman, J.V.,Moran, G.R. (deposition date: 2019-06-12, release date: 2019-09-18, Last modification date: 2023-10-11)
Primary citation	Roman, J.V.,Melkonian, T.R.,Silvaggi, N.R.,Moran, G.R. Transient-State Analysis of Human Isocitrate Dehydrogenase I: Accounting for the Interconversion of Active and Non-Active Conformational States. Biochemistry, 58:5366-5380, 2019 Cited by PubMed: 31478653 DOI: 10.1021/acs.biochem.9b00518 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.199 Å)

Structure validation