2J8T

Human aldose reductase in complex with NADP and citrate at 0.82 angstrom

Summary for 2J8T

• Entry DOI: 10.2210/pdb2j8t/pdb
• Related: 2FZB 2FZD
• Descriptor: ALDO-KETO REDUCTASE FAMILY 1, MEMBER B1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRATE ANION, ... (4 entities in total)
• Functional Keywords: oxidoreductase, nadp, citrate
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 37019.94

Authors

Biadene, M.,Hazemann, I.,Cousido, A.,Ginell, S.,Sheldrick, G.M.,Podjarny, A.,Schneider, T.R. (deposition date: 2006-10-27, release date: 2007-05-29, Last modification date: 2023-12-13)

• Primary citation: Biadene, M.,Hazemann, I.,Cousido, A.,Ginell, S.,Joachimiak, A.,Sheldrick, G.M.,Podjarny, A.,Schneider, T.R.; The Atomic Resolution Structure of Human Aldose Reductase Reveals that Rearrangement of a Bound Ligand Allows the Opening of the Safety-Belt Loop.; Acta Crystallogr.,Sect.D, 63:665-, 2007; PubMed: 17505104; DOI: 10.1107/S0907444907011997

Experimental method

X-RAY DIFFRACTION (0.82 Å)