2FZB

Human Aldose Reductase complexed with four tolrestat molecules at 1.5 A resolution.

Summary for 2FZB

Entry DOI	10.2210/pdb2fzb/pdb
Related	1AH3 2FZ9 2FZD 2fz8
Descriptor	aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TOLRESTAT, ... (4 entities in total)
Functional Keywords	tim barrel, four ligand structure, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	38071.13
Authors	Steuber, H.,Zentgraf, M.,Gerlach, C.,Sotriffer, C.A.,Heine, A.,Klebe, G. (deposition date: 2006-02-09, release date: 2006-10-03, Last modification date: 2023-08-30)
Primary citation	Steuber, H.,Zentgraf, M.,Gerlach, C.,Sotriffer, C.A.,Heine, A.,Klebe, G. Expect the Unexpected or Caveat for Drug Designers: Multiple Structure Determinations Using Aldose Reductase Crystals Treated under Varying Soaking and Co-crystallisation Conditions. J.Mol.Biol., 363:174-187, 2006 Cited by PubMed: 16952371 DOI: 10.1016/j.jmb.2006.08.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation