7MX1

PLK-1 polo-box domain in complex with a high affinity macrocycle synthesized using a novel glutamic acid analog

Summary for 7MX1

Entry DOI	10.2210/pdb7mx1/pdb
Descriptor	Serine/threonine-protein kinase PLK1, ACE-PRO-LEU-ALA-SER-TPO, N-[(4S)-4,5-diamino-5-oxopentyl]-10-phenyldecanamide, ... (4 entities in total)
Functional Keywords	macrocyclic phosphopeptide, mitotic kinase. polo-box domain, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	56480.49
Authors	Grant, R.A.,Hymel, D.,Yaffe, M.B.,Burke, T.R. (deposition date: 2021-05-17, release date: 2022-03-30, Last modification date: 2023-10-18)
Primary citation	Hymel, D.,Tsuji, K.,Grant, R.A.,Chingle, R.M.,Kunciw, D.L.,Yaffe, M.B.,Burke Jr., T.R. Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain - binding peptide macrocycles. Org.Biomol.Chem., 19:7843-7854, 2021 Cited by PubMed: 34346472 DOI: 10.1039/d1ob01120k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.64 Å)

Structure validation