7MX1
PLK-1 polo-box domain in complex with a high affinity macrocycle synthesized using a novel glutamic acid analog
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Serine/threonine-protein kinase PLK1 | polymer | 237 | 27285.2 | 2 | UniProt (P53350) Pfam (PF00659) In PDB | Homo sapiens (Human) | Polo-like kinase 1,PLK-1,Serine/threonine-protein kinase 13,STPK13 |
2 | C, E | ACE-PRO-LEU-ALA-SER-TPO | polymer | 6 | 593.6 | 2 | Homo sapiens | ||
3 | C, E | N-[(4S)-4,5-diamino-5-oxopentyl]-10-phenyldecanamide | non-polymer | 361.5 | 2 | Chemie (ZOY) | |||
4 | water | water | 18.0 | 470 | Chemie (HOH) |
Sequence modifications
A, B: 371 - 603 (UniProt: P53350)
PDB | External Database | Details |
---|---|---|
Gly 367 | - | expression tag |
Ala 368 | - | expression tag |
His 369 | - | expression tag |
Met 370 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 55757.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 723.0 | |
All* | Total formula weight | 56480.5 |