7MX1
PLK-1 polo-box domain in complex with a high affinity macrocycle synthesized using a novel glutamic acid analog
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase PLK1 | polymer | 237 | 27285.2 | 2 | UniProt (P53350) Pfam (PF00659) | Homo sapiens (Human) | Polo-like kinase 1,PLK-1,Serine/threonine-protein kinase 13,STPK13 |
| 2 | C, D (C, E) | ACE-PRO-LEU-ALA-SER-TPO | polymer | 6 | 593.6 | 2 | Homo sapiens | ||
| 3 | E, F (C, E) | N-[(4S)-4,5-diamino-5-oxopentyl]-10-phenyldecanamide | non-polymer | 361.5 | 2 | Chemie (ZOY) | |||
| 4 | G, H, I, J (A, B, C, E) | water | water | 18.0 | 470 | Chemie (HOH) |
Sequence modifications
A, B: 371 - 603 (UniProt: P53350)
| PDB | External Database | Details |
|---|---|---|
| Gly 367 | - | expression tag |
| Ala 368 | - | expression tag |
| His 369 | - | expression tag |
| Met 370 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 55757.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 723.0 | |
| All* | Total formula weight | 56480.5 |
