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PDB: 291 件
2FR0
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The first ketoreductase of the erythromycin synthase (crystal form 1)
分子名称: Erythromycin synthase, EryAI, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Keatinge-Clay, A.T, Stroud, R.M.
登録日2006-01-18
公開日2006-04-04
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献The Structure of a Ketoreductase Determines the Organization of the beta-Carbon Processing Enzymes of Modular Polyketide Synthases
Structure, 14, 2006
2FR1
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The first ketoreductase of the erythromycin synthase (crystal form 2)
分子名称: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, erythromycin synthase, EryAI
著者Keatinge-Clay, A.T, Stroud, R.M.
登録日2006-01-18
公開日2006-04-04
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献The Structure of a Ketoreductase Determines the Organization of the beta-Carbon Processing Enzymes of Modular Polyketide Synthases
Structure, 14, 2006
2G8A
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Lactobacillus casei Y261M in complex with substrate, dUMP
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, thymidylate synthase
著者Finer-Moore, J.S, Stroud, R.M.
登録日2006-03-02
公開日2006-03-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261
Biochemistry, 45, 2006
1DDU
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E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717 AND 2',5'-DIDEOXYURIDINE (DDURD)
分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-5'DIDEOXYURIDINE, PHOSPHATE ION, ...
著者Stout, T.J, Sage, C.R, Stroud, R.M.
登録日1997-06-26
公開日1998-07-01
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The additivity of substrate fragments in enzyme-ligand binding.
Structure, 6, 1998
1EXQ
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CRYSTAL STRUCTURE OF THE HIV-1 INTEGRASE CATALYTIC CORE DOMAIN
分子名称: CADMIUM ION, CHLORIDE ION, POL POLYPROTEIN, ...
著者Chen, J.C.-H, Krucinski, J, Miercke, L.J.W, Finer-Moore, J.S, Tang, A.H, Leavitt, A.D, Stroud, R.M.
登録日2000-05-03
公開日2000-11-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding.
Proc.Natl.Acad.Sci.USA, 97, 2000
1EX4
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HIV-1 INTEGRASE CATALYTIC CORE AND C-TERMINAL DOMAIN
分子名称: 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, INTEGRASE
著者Chen, J.C.-H, Krucinski, J, Miercke, L.J.W, Finer-Moore, J.S, Tang, A.H, Leavitt, A.D, Stroud, R.M.
登録日2000-04-28
公開日2000-06-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding.
Proc.Natl.Acad.Sci.USA, 97, 2000
1F4D
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CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE C146S, L143C COVALENTLY MODIFIED AT C143 WITH N-[TOSYL-D-PROLINYL]AMINO-ETHANETHIOL
分子名称: GLYCEROL, N-[TOSYL-D-PROLINYL]AMINO-ETHANETHIOL, SULFATE ION, ...
著者Erlanson, D.A, Braisted, A.C, Raphael, D.R, Randal, M, Stroud, R.M, Gordon, E, Wells, J.A.
登録日2000-06-07
公開日2000-06-22
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Site-directed ligand discovery.
Proc.Natl.Acad.Sci.USA, 97, 2000
1JTU
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E. coli Thymidylate Synthase in a Complex with dUMP and LY338913, A Polyglutamylated Pyrrolo(2,3-d)pyrimidine-based Antifolate
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-{4-[4-(4-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-4-CARBOXY-BUTYRYLAMIN O)-4-CARBOXY-BUTYRYLAMINO}-PENTANEDIOIC ACID, THYMIDYLATE SYNTHASE
著者Sayre, P.H, Finer-Moore, J.S, Fritz, T.A, Biermann, D, Gates, S.B, MacKellar, W.C, Patel, V.F, Stroud, R.M.
登録日2001-08-22
公開日2001-09-19
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.
J.Mol.Biol., 313, 2001
1F4B
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI THYMIDYLATE SYNTHASE
分子名称: GLYCEROL, SULFATE ION, THYMIDYLATE SYNTHASE
著者Erlanson, D.A, Braisted, A.C, Raphael, D.R, Randal, M, Stroud, R.M, Gordon, E, Wells, J.A.
登録日2000-06-07
公開日2000-06-22
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Site-directed ligand discovery.
Proc.Natl.Acad.Sci.USA, 97, 2000
1F4F
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CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH SP-722
分子名称: 4-[[GLUTAMIC ACID]-CARBONYL]-BENZENE-SULFONYL-D-PROLINE, SULFATE ION, THYMIDYLATE SYNTHASE
著者Erlanson, D.A, Braisted, A.C, Raphael, D.R, Randal, M, Stroud, R.M, Gordon, E, Wells, J.A.
登録日2000-06-07
公開日2000-06-22
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Site-directed ligand discovery.
Proc.Natl.Acad.Sci.USA, 97, 2000
1F28
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, THYMIDYLATE SYNTHASE
著者Anderson, A.C, O'Neil, R.H, Surti, T.S, Stroud, R.M.
登録日2000-05-23
公開日2001-06-06
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Approaches to solving the rigid receptor problem by identifying a minimal set of flexible residues during ligand docking.
Chem.Biol., 8, 2001
1F4E
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CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH TOSYL-D-PROLINE
分子名称: GLYCEROL, SULFATE ION, THYMIDYLATE SYNTHASE, ...
著者Erlanson, D.A, Braisted, A.C, Raphael, D.R, Randal, M, Stroud, R.M, Gordon, E, Wells, J.A.
登録日2000-06-07
公開日2000-06-22
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Site-directed ligand discovery.
Proc.Natl.Acad.Sci.USA, 97, 2000
1F4G
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CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH SP-876
分子名称: GLYCEROL, N-[4-[[GLUTAMIC ACID]-CARBONYL]-BENZENE-SULFONYL-D-PROLINYL]-3-AMINO-PROPANOIC ACID, SULFATE ION, ...
著者Erlanson, D.A, Braisted, A.C, Raphael, D.R, Randal, M, Stroud, R.M, Gordon, E, Wells, J.A.
登録日2000-06-07
公開日2000-06-22
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Site-directed ligand discovery.
Proc.Natl.Acad.Sci.USA, 97, 2000
1F4C
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CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COVALENTLY MODIFIED AT C146 WITH N-[TOSYL-D-PROLINYL]AMINO-ETHANETHIOL
分子名称: GLYCEROL, N-[TOSYL-D-PROLINYL]AMINO-ETHANETHIOL, SULFATE ION, ...
著者Erlanson, D.A, Braisted, A.C, Raphael, D.R, Randal, M, Stroud, R.M, Gordon, E, Wells, J.A.
登録日2000-06-07
公開日2000-06-22
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Site-directed ligand discovery.
Proc.Natl.Acad.Sci.USA, 97, 2000
1FL1
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KSHV PROTEASE
分子名称: POTASSIUM ION, PROTEASE
著者Reiling, K.K, Pray, T.R, Craik, C.S, Stroud, R.M.
登録日2000-08-11
公開日2000-11-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements.
Biochemistry, 39, 2000
1KCE
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E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)
分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
著者Sage, C.R, Rutenber, E.E, Stout, T.J, Stroud, R.M.
登録日1996-10-22
公開日1997-04-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q.
Biochemistry, 35, 1996
1FFH
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N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS
分子名称: FFH, MAGNESIUM ION
著者Freymann, D.M, Keenan, R.J, Stroud, R.M, Walter, P.
登録日1996-12-30
公開日1997-12-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structure of the conserved GTPase domain of the signal recognition particle.
Nature, 385, 1997
1FX8
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CRYSTAL STRUCTURE OF THE E. COLI GLYCEROL FACILITATOR (GLPF) WITH SUBSTRATE GLYCEROL
分子名称: GLYCEROL, GLYCEROL UPTAKE FACILITATOR PROTEIN, octyl beta-D-glucopyranoside
著者Fu, D, Libson, A, Miercke, L.J.W, Weitzman, C, Nollert, P, Stroud, R.M.
登録日2000-09-25
公開日2000-11-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of a glycerol-conducting channel and the basis for its selectivity.
Science, 290, 2000
1I5P
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INSECTICIDAL CRYSTAL PROTEIN CRY2AA
分子名称: PESTICIDIAL CRYSTAL PROTEIN CRY2AA
著者Morse, R.J, Stroud, R.M, Yamamoto, T.
登録日2001-02-28
公開日2001-05-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of Cry2Aa suggests an unexpected receptor binding epitope.
Structure, 9, 2001
1NCE
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Crystal structure of a ternary complex of E. coli thymidylate synthase D169C with dUMP and the antifolate CB3717
分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase
著者Birdsall, D.L, Finer-Moore, J, Stroud, R.M.
登録日2002-12-05
公開日2002-12-25
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The only active mutant of thymidylate synthase D169, a residue far from the site of methyl transfer, demonstrates the exquisite nature of enzyme specificity.
Protein Eng., 16, 2003
1NJE
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THYMIDYLATE SYNTHASE WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP)
分子名称: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
著者Finer-Moore, J, Stroud, R.M.
登録日1996-01-23
公開日1996-07-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
Biochemistry, 35, 1996
1NJB
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THYMIDYLATE SYNTHASE
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
著者Finer-Moore, J, Stroud, R.M.
登録日1996-01-23
公開日1996-10-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
Biochemistry, 35, 1996
1NJD
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THYMIDYLATE SYNTHASE, MUTATION, N229D WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
著者Finer-Moore, J, Stroud, R.M.
登録日1996-01-23
公開日1996-07-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
Biochemistry, 35, 1996
1NJA
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THYMIDYLATE SYNTHASE, MUTATION, N229C WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP)
分子名称: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
著者Finer-Moore, J, Stroud, R.M.
登録日1996-01-23
公開日1996-07-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
Biochemistry, 35, 1996
1NJC
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THYMIDYLATE SYNTHASE, MUTATION, N229D WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP)
分子名称: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
著者Finer-Moore, J, Stroud, R.M.
登録日1996-01-23
公開日1996-07-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
Biochemistry, 35, 1996

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