1F28

CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89

Summary for 1F28

Related1CI7
DescriptorTHYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, ... (4 entities in total)
Functional Keywordsbeta-sheet, protein-inhibitor complex, transferase
Biological sourcePneumocystis carinii
Total number of polymer chains4
Total molecular weight140847.86
Authors
Anderson, A.C.,O'Neil, R.H.,Surti, T.S.,Stroud, R.M. (deposition date: 2000-05-23, release date: 2001-06-06, Last modification date: 2018-01-31)
Primary citation
Anderson, A.C.,O'Neil, R.H.,Surti, T.S.,Stroud, R.M.
Approaches to solving the rigid receptor problem by identifying a minimal set of flexible residues during ligand docking.
Chem.Biol., 8:445-457, 2001
PubMed: 11358692 (PDB entries with the same primary citation)
DOI: 10.1016/S1074-5521(01)00023-0
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers20 0.9% 6.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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170172
PDB entries from 2020-10-21