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1F28

CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89

Functional Information from GO Data
ChainGOidnamespacecontents
A0004799molecular_functionthymidylate synthase activity
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006231biological_processdTMP biosynthetic process
A0006235biological_processdTTP biosynthetic process
A0008168molecular_functionmethyltransferase activity
A0009165biological_processnucleotide biosynthetic process
A0016741molecular_functiontransferase activity, transferring one-carbon groups
A0032259biological_processmethylation
B0004799molecular_functionthymidylate synthase activity
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006231biological_processdTMP biosynthetic process
B0006235biological_processdTTP biosynthetic process
B0008168molecular_functionmethyltransferase activity
B0009165biological_processnucleotide biosynthetic process
B0016741molecular_functiontransferase activity, transferring one-carbon groups
B0032259biological_processmethylation
C0004799molecular_functionthymidylate synthase activity
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0006231biological_processdTMP biosynthetic process
C0006235biological_processdTTP biosynthetic process
C0008168molecular_functionmethyltransferase activity
C0009165biological_processnucleotide biosynthetic process
C0016741molecular_functiontransferase activity, transferring one-carbon groups
C0032259biological_processmethylation
D0004799molecular_functionthymidylate synthase activity
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0006231biological_processdTMP biosynthetic process
D0006235biological_processdTTP biosynthetic process
D0008168molecular_functionmethyltransferase activity
D0009165biological_processnucleotide biosynthetic process
D0016741molecular_functiontransferase activity, transferring one-carbon groups
D0032259biological_processmethylation
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE UMP A 301
ChainResidue
AARG26
AASN210
AHIS240
ATYR242
AF89401
AHOH519
BARG153
BARG154
BHOH741
ALEU170
ACYS173
AHIS174
AGLN198
AARG199
ASER200
AASP202
AGLY206

site_idAC2
Number of Residues16
DetailsBINDING SITE FOR RESIDUE UMP B 302
ChainResidue
AARG153
AARG154
BARG26
BLEU170
BCYS173
BHIS174
BGLN198
BARG199
BSER200
BASP202
BASN210
BHIS240
BTYR242
BF89402
BHOH682
BHOH748

site_idAC3
Number of Residues17
DetailsBINDING SITE FOR RESIDUE UMP C 303
ChainResidue
CARG26
CTYR113
CLEU170
CCYS173
CHIS174
CGLN198
CARG199
CSER200
CASP202
CGLY206
CASN210
CHIS240
CTYR242
CF89403
CHOH589
DARG153
DARG154

site_idAC4
Number of Residues16
DetailsBINDING SITE FOR RESIDUE UMP D 304
ChainResidue
CARG153
CARG154
CHOH756
DARG26
DLEU170
DCYS173
DHIS174
DGLN198
DARG199
DSER200
DASP202
DASN210
DHIS240
DTYR242
DF89404
DHOH690

site_idAC5
Number of Residues14
DetailsBINDING SITE FOR RESIDUE F89 A 401
ChainResidue
APHE58
AGLY61
AGLU65
AHIS85
AILE86
ATRP87
AASN90
ALEU170
AASP202
ALEU205
AGLY206
APHE209
ASER296
AUMP301

site_idAC6
Number of Residues15
DetailsBINDING SITE FOR RESIDUE F89 B 402
ChainResidue
BPHE58
BGLY61
BGLU65
BHIS85
BILE86
BTRP87
BASN90
BASP202
BGLY206
BPHE209
BTYR242
BMET295
BILE297
BUMP302
BHOH643

site_idAC7
Number of Residues15
DetailsBINDING SITE FOR RESIDUE F89 C 403
ChainResidue
CILE86
CTRP87
CASN90
CLEU170
CASP202
CLEU205
CGLY206
CPHE209
CTYR242
CSER296
CUMP303
CPHE58
CGLY61
CGLU65
CHIS85

site_idAC8
Number of Residues14
DetailsBINDING SITE FOR RESIDUE F89 D 404
ChainResidue
DPHE58
DGLY61
DGLU65
DHIS85
DILE86
DTRP87
DASN90
DASP202
DGLY206
DPHE209
DTYR242
DMET295
DILE297
DUMP304

Functional Information from PROSITE/UniProt
site_idPS00091
Number of Residues29
DetailsTHYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrlIlsaWNpadlekma.....LpPCHmfcQFyV
ChainResidueDetails
AARG153-VAL181

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P0A884
ChainResidueDetails
ACYS173
BCYS173
CCYS173
DCYS173

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING: in other chain => ECO:0000250|UniProtKB:P0A884
ChainResidueDetails
AARG26
CARG199
CASN210
CHIS240
DARG26
DARG199
DASN210
DHIS240
AARG199
AASN210
AHIS240
BARG26
BARG199
BASN210
BHIS240
CARG26

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P0A884
ChainResidueDetails
AARG153
AASP202
BARG153
BASP202
CARG153
CASP202
DARG153
DASP202

Catalytic Information from CSA
site_idCSA1
Number of Residues6
DetailsAnnotated By Reference To The Literature 1lcb
ChainResidueDetails
ASER200
AASP238
AGLU65
ACYS173
AHIS240
AASP202

site_idCSA2
Number of Residues6
DetailsAnnotated By Reference To The Literature 1lcb
ChainResidueDetails
BSER200
BASP238
BGLU65
BCYS173
BHIS240
BASP202

site_idCSA3
Number of Residues6
DetailsAnnotated By Reference To The Literature 1lcb
ChainResidueDetails
CSER200
CASP238
CGLU65
CCYS173
CHIS240
CASP202

site_idCSA4
Number of Residues6
DetailsAnnotated By Reference To The Literature 1lcb
ChainResidueDetails
DSER200
DASP238
DGLU65
DCYS173
DHIS240
DASP202

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PDB entries from 2024-09-18

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