4JKR
| Crystal Structure of E. coli RNA Polymerase in complex with ppGpp | Descriptor: | DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA', DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Zuo, Y, Wang, Y, Steitz, T.A. | Deposit date: | 2013-03-11 | Release date: | 2013-05-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex. Mol.Cell, 50, 2013
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354D
| Structure of loop E FROM E. coli 5S RRNA | Descriptor: | MAGNESIUM ION, RNA (5'-R(*CP*CP*GP*AP*UP*GP*GP*UP*AP*GP*UP*G)-3'), RNA-DNA (5'-R(*GP*CP*GP*AP*GP*AP*GP*UP*AP*)-D(*DGP(S)*)-R(*GP*C)-3') | Authors: | Correll, C.C, Freeborn, B, Moore, P.B, Steitz, T.A. | Deposit date: | 1997-10-01 | Release date: | 1997-11-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Metals, motifs, and recognition in the crystal structure of a 5S rRNA domain. Cell(Cambridge,Mass.), 91, 1997
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4KZZ
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357D
| 3.5 A structure of fragment I from E. coli 5S RRNA | Descriptor: | MAGNESIUM ION, MERCURY (II) ION, RNA (5'-R(*CP*CP*CP*CP*AP*UP*GP*CP*GP*AP*GP*AP*GP*UP*AP*GP*G P*GP*AP*AP*CP*UP* GP*CP*CP*AP*GP*GP*CP*AP*U)-3'), ... | Authors: | Correll, C.C, Freeborn, B, Moore, P.B, Steitz, T.A. | Deposit date: | 1997-10-09 | Release date: | 1997-12-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Metals, motifs, and recognition in the crystal structure of a 5S rRNA domain. Cell(Cambridge,Mass.), 91, 1997
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364D
| 3.0 A STRUCTURE OF FRAGMENT I FROM E. COLI 5S RRNA | Descriptor: | MAGNESIUM ION, RNA (5'-R(*CP*CP*CP*CP*AP*UP*GP*CP*GP*AP*GP*AP*GP*UP*AP*GP*G P*GP*AP*AP*CP*UP*GP*CP*CP*AP*GP*GP*CP*AP*U)-3'), RNA (5'-R(*CP*CP*GP*AP*UP*GP*GP*UP*AP*GP*UP*GP*UP*GP*GP*GP*G *UP*C)-3'), ... | Authors: | Correll, C.C, Freeborn, B, Moore, P.B, Steitz, T.A. | Deposit date: | 1997-12-08 | Release date: | 1998-01-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Metals, motifs, and recognition in the crystal structure of a 5S rRNA domain. Cell(Cambridge,Mass.), 91, 1997
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3OVS
| How the CCA-adding Enzyme Selects Adenine over Cytosine in Position 76 of tRNA | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, CCA-Adding Enzyme, ... | Authors: | Pan, B.C, Xiong, Y, Steitz, T.A. | Deposit date: | 2010-09-17 | Release date: | 2010-12-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | How the CCA-Adding Enzyme Selects Adenine over Cytosine at Position 76 of tRNA. Science, 330, 2010
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3OVB
| How the CCA-adding Enzyme Selects Adenine over Cytosine in Position 76 of tRNA | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, CCA-Adding Enzyme, ... | Authors: | Pan, B.C, Xiong, Y, Steitz, T.A. | Deposit date: | 2010-09-16 | Release date: | 2010-12-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | How the CCA-Adding Enzyme Selects Adenine over Cytosine at Position 76 of tRNA. Science, 330, 2010
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1GTS
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4KZX
| Rabbit 40S ribosomal subunit in complex with eIF1. | Descriptor: | 18S ribosomal RNA, 40S Ribosomal protein S9, 40S ribosomal protein RACK1, ... | Authors: | Lomakin, I.B, Steitz, T.A. | Deposit date: | 2013-05-30 | Release date: | 2013-07-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (7.809 Å) | Cite: | The initiation of mammalian protein synthesis and mRNA scanning mechanism. Nature, 500, 2013
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4KZY
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5IPL
| SigmaS-transcription initiation complex with 4-nt nascent RNA | Descriptor: | DIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Liu, B, Zuo, Y, Steitz, T.A. | Deposit date: | 2016-03-09 | Release date: | 2016-03-30 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
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1KFD
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5IPM
| SigmaS-transcription initiation complex with 4-nt nascent RNA | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Liu, B, Zuo, Y, Steitz, T.A. | Deposit date: | 2016-03-09 | Release date: | 2016-03-30 | Last modified: | 2016-06-22 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
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5IPN
| SigmaS-transcription initiation complex with 4-nt nascent RNA | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Liu, B, Zuo, Y, Steitz, T.A. | Deposit date: | 2016-03-09 | Release date: | 2016-03-30 | Last modified: | 2016-06-22 | Method: | X-RAY DIFFRACTION (4.61 Å) | Cite: | Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
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4S20
| Structural basis for transcription reactivation by RapA | Descriptor: | 5'-D(P*AP*CP*GP*AP*CP*TP*GP*AP*GP*CP*CP*GP*AP*TP*G)-3', 5'-R(P*AP*UP*CP*GP*GP*CP*UP*CP*A)-3', DNA-directed RNA polymerase subunit alpha, ... | Authors: | Liu, B, Zuo, Y, Steitz, T.A. | Deposit date: | 2015-01-16 | Release date: | 2015-02-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (4.7 Å) | Cite: | Structural basis for transcription reactivation by RapA. Proc.Natl.Acad.Sci.USA, 112, 2015
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2HPI
| Eubacterial and Eukaryotic Replicative DNA Polymerases are not Homologous: X-ray Structure of DNA Polymerase III | Descriptor: | CHLORIDE ION, DNA polymerase III alpha subunit, MAGNESIUM ION, ... | Authors: | Bailey, S, Wing, R.A, Steitz, T.A. | Deposit date: | 2006-07-17 | Release date: | 2006-09-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The Structure of T. aquaticus DNA Polymerase III Is Distinct from Eukaryotic Replicative DNA Polymerases. Cell(Cambridge,Mass.), 126, 2006
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2HPM
| Eubacterial and Eukaryotic Replicative DNA Polymerases are not Homologous: X-ray Structure of DNA Polymerase III | Descriptor: | CHLORIDE ION, DNA Polymerase III alpha subunit, MAGNESIUM ION, ... | Authors: | Bailey, S, Wing, R.A, Steitz, T.A. | Deposit date: | 2006-07-17 | Release date: | 2006-09-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | The Structure of T. aquaticus DNA Polymerase III Is Distinct from Eukaryotic Replicative DNA Polymerases. Cell(Cambridge,Mass.), 126, 2006
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1YI2
| Crystal Structure Of Erythromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui | Descriptor: | 23S Ribosomal RNA, 50S RIBOSOMAL PROTEIN L10E, 50S RIBOSOMAL PROTEIN L11P, ... | Authors: | Tu, D, Blaha, G, Moore, P.B, Steitz, T.A. | Deposit date: | 2005-01-11 | Release date: | 2005-04-26 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell(Cambridge,Mass.), 121, 2005
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1YIJ
| Crystal Structure Of Telithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui | Descriptor: | 23S Ribosomal RNA, 50S RIBOSOMAL PROTEIN L10E, 50S RIBOSOMAL PROTEIN L11P, ... | Authors: | Tu, D, Blaha, G, Moore, P.B, Steitz, T.A. | Deposit date: | 2005-01-12 | Release date: | 2005-04-26 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell(Cambridge,Mass.), 121, 2005
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1YJ9
| Crystal Structure Of The Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui Containing a three residue deletion in L22 | Descriptor: | 23S Ribosomal RNA, 50S RIBOSOMAL PROTEIN L10E, 50S RIBOSOMAL PROTEIN L11P, ... | Authors: | Tu, D, Blaha, G, Moore, P.B, Steitz, T.A. | Deposit date: | 2005-01-13 | Release date: | 2005-04-26 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell(Cambridge,Mass.), 121, 2005
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1YJN
| Crystal Structure Of Clindamycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui | Descriptor: | 23S Ribosomal RNA, 50S RIBOSOMAL PROTEIN L10E, 50S RIBOSOMAL PROTEIN L11P, ... | Authors: | Tu, D, Blaha, G, Moore, P.B, Steitz, T.A. | Deposit date: | 2005-01-14 | Release date: | 2005-04-26 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell(Cambridge,Mass.), 121, 2005
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3FWE
| Crystal Structure of the Apo D138L CAP mutant | Descriptor: | Catabolite gene activator, PROLINE | Authors: | Sharma, H, Wang, J, Kong, J, Yu, S, Steitz, T. | Deposit date: | 2009-01-17 | Release date: | 2009-09-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding Proc.Natl.Acad.Sci.USA, 106, 2009
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2KZM
| KLENOW FRAGMENT WITH NORMAL SUBSTRATE AND ZINC AND MANGANESE | Descriptor: | DNA (5'-D(*GP*CP*TP*TP*A*CP*GP*C)-3'), MANGANESE (II) ION, PROTEIN (DNA POLYMERASE I), ... | Authors: | Brautigam, C.A, Sun, S, Piccirilli, J.A, Steitz, T.A. | Deposit date: | 1998-07-03 | Release date: | 1999-02-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli. Biochemistry, 38, 1999
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6C0K
| Crystal structure of HIV-1 K103N mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2 | Descriptor: | 1,2-ETHANEDIOL, 4-[(4-{[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino}piperidin-1-yl)methyl]benzene-1-sulfonamide, DIMETHYL SULFOXIDE, ... | Authors: | Yang, Y, Nguyen, L.A, Smithline, Z.B, Steitz, T.A. | Deposit date: | 2018-01-01 | Release date: | 2018-08-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.958 Å) | Cite: | Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors. Elife, 7, 2018
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6CGF
| Crystal structure of HIV-1 Y188L mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2 | Descriptor: | 1,2-ETHANEDIOL, 4-[(4-{[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino}piperidin-1-yl)methyl]benzene-1-sulfonamide, MAGNESIUM ION, ... | Authors: | Yang, Y, Nguyen, L.A, Smithline, Z.B, Steitz, T.A. | Deposit date: | 2018-02-20 | Release date: | 2018-08-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors. Elife, 7, 2018
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