3HL2

The crystal structure of the human SepSecS-tRNASec complex

Summary for 3HL2

DescriptorO-phosphoseryl-tRNA(Sec) selenium transferase, tRNASec, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, ... (6 entities in total)
Functional Keywordsselenocysteine, trnasec, sepsecs, protein-rna complex, alternative splicing, cytoplasm, protein biosynthesis, pyridoxal phosphate, selenium, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm  Q9HD40
Total number of polymer chains5
Total molecular weight254128.03
Authors
Palioura, S.,Steitz, T.A.,Soll, D.,Simonovic, M. (deposition date: 2009-05-26, release date: 2009-10-06, Last modification date: 2018-01-24)
Primary citation
Palioura, S.,Sherrer, R.L.,Steitz, T.A.,Soll, D.,Simonovic, M.
The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation.
Science, 325:321-325, 2009
PubMed: 19608919 (PDB entries with the same primary citation)
DOI: 10.1126/science.1173755
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.81 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone180.2%0.1%1.6%0.49MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3hl2
no rotation
Molmil generated image of 3hl2
rotated about x axis by 90°
Molmil generated image of 3hl2
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 3hl2
no rotation
Molmil generated image of 3hl2
rotated about x axis by 90°
Molmil generated image of 3hl2
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3hl2.pdb2.gz [353.92 KB])
Coordinate files for Biological unit (3hl2.pdb1.gz [357.16 KB])
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