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PDB: 349 results
3UTZ
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BU of 3utz by Molmil
Endogenous-like inhibitory antibodies targeting activated metalloproteinase motifs show therapeutic potential
Descriptor: Metalloproteinase, heavy chain, light chain, ...
Authors:Sela-Passwell, N, Kikkeri, R, Dym, O, Rozenberg, H, Margalit, R, Arad-Yellin, R, Eisenstein, M, Brenner, O, Shoham, T, Danon, T, Shanzer, A, Sagi, I, Israel Structural Proteomics Center (ISPC)
Deposit date:2011-11-27
Release date:2011-12-14
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential.
NAT.MED. (N.Y.), 18, 2012
4IIJ
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BU of 4iij by Molmil
Crystal structure of tubulin-stathmin-TTL-apo complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ...
Authors:Prota, A.E, Magiera, M.M, Kuijpers, M, Bargsten, K, Frey, D, Wieser, M, Jaussi, R, Hoogenraad, C.C, Kammerer, R.A, Janke, C, Steinmetz, M.O.
Deposit date:2012-12-20
Release date:2013-01-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of tubulin tyrosination by tubulin tyrosine ligase.
J.Cell Biol., 200, 2013
2HKQ
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BU of 2hkq by Molmil
Crystal structure of the C-terminal domain of human EB1 in complex with the CAP-Gly domain of human Dynactin-1 (p150-Glued)
Descriptor: Dynactin-1, Microtubule-associated protein RP/EB family member 1
Authors:Honnappa, S, Winkler, F.K, Steinmetz, M.O.
Deposit date:2006-07-05
Release date:2006-09-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Key interaction modes of dynamic +TIP networks.
Mol.Cell, 23, 2006
6FJM
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BU of 6fjm by Molmil
tubulin-Disorazole Z complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, Disorazole Z, ...
Authors:Menchon, G, Prota, A.E, Lucena Agell, D, Bucher, P, Jansen, R, Irschik, H, Mueller, R, Paterson, I, Diaz, J.F, Altmann, K.-H, Steinmetz, M.O.
Deposit date:2018-01-22
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Nat Commun, 9, 2018
7UHY
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BU of 7uhy by Molmil
Human GATOR2 complex
Descriptor: GATOR complex protein MIOS, GATOR complex protein WDR24, GATOR complex protein WDR59, ...
Authors:Rogala, K.B, Valenstein, M.L, Lalgudi, P.V.
Deposit date:2022-03-27
Release date:2022-07-20
Last modified:2022-08-03
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Structure of the nutrient-sensing hub GATOR2.
Nature, 607, 2022
6FLK
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BU of 6flk by Molmil
Crystal structure of Cep120 C2C domain
Descriptor: Cep120
Authors:Sharma, A, Gerard, S.F, Olieric, N, Steinmetz, M.O.
Deposit date:2018-01-26
Release date:2018-02-14
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Cep120 promotes microtubule formation through a unique tubulin binding C2 domain.
J. Struct. Biol., 203, 2018
1VT7
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BU of 1vt7 by Molmil
Structures of the mismatched duplex D(GGGTGCCC)
Descriptor: DNA (5'-D(*GP*GP*GP*TP*GP*CP*CP*C)-3')
Authors:Rabinovich, D, Haran, T, Eisenstein, M, Shakked, Z.
Deposit date:1996-12-02
Release date:2011-07-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the mismatched duplex d(GGGTGCCC) and one of its Watson-Crick analogues d(GGGCGCCC).
J.Mol.Biol., 200, 1988
6FII
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BU of 6fii by Molmil
Tubulin-Spongistatin complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DIMETHYL SULFOXIDE, ...
Authors:Menchon, G, Prota, A.E, Lucena Angell, D, Bucher, P, Mueller, R, Paterson, I, Diaz, J.F, Altmann, K.-H, Steinmetz, M.O.
Deposit date:2018-01-18
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Nat Commun, 9, 2018
6FLJ
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BU of 6flj by Molmil
Crystal structure of Cep120 C2A_K76A mutant
Descriptor: Centrosomal protein of 120 kDa
Authors:Sharma, A, Gerard, S.F, Olieric, N, Steinmetz, M.O.
Deposit date:2018-01-26
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Cep120 promotes microtubule formation through a unique tubulin binding C2 domain.
J. Struct. Biol., 203, 2018
6FJF
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BU of 6fjf by Molmil
Tubulin-FcMaytansine complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Menchon, G, Prota, A.E, Lucena Angell, D, Bucher, P, Mueller, R, Paterson, I, Diaz, J.F, Altmann, K.-H, Steinmetz, M.O.
Deposit date:2018-01-22
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Nat Commun, 9, 2018
3L3S
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BU of 3l3s by Molmil
Crystal structure of an enoyl-CoA hydrotase/isomerase family protein from Silicibacter pomeroyi
Descriptor: Enoyl-CoA hydratase/isomerase family protein
Authors:Eswaramoorthy, S, Silberstein, M, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2009-12-17
Release date:2010-01-05
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Crystal structure of an enoyl-CoA hydrotase/isomerase family protein from Silicibacter pomeroyi
To be Published
4I55
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BU of 4i55 by Molmil
Crystal structure of tubulin-stathmin-TTL complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ...
Authors:Prota, A.E, Bargsten, K, Zurwerra, D, Field, J.J, Diaz, J.F, Altmann, K.H, Steinmetz, M.O.
Deposit date:2012-11-28
Release date:2013-01-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents.
Science, 339, 2013
1USX
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BU of 1usx by Molmil
Crystal structure of the Newcastle disease virus hemagglutinin-neuraminidase complexed with thiosialoside
Descriptor: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN, N-acetyl-alpha-neuraminic acid-(2-6)-methyl 6-thio-beta-D-galactopyranoside
Authors:Zaitsev, V, Itzstein, M, Groves, D, Kiefel, M, Takimoto, T, Portner, A, Taylor, G.
Deposit date:2003-12-01
Release date:2004-03-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Second Sialic Acid Binding Site in Newcastle Disease Virus Hemagglutinin-Neuraminidase: Implications for Fusion
J.Virol., 78, 2004
4J4A
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BU of 4j4a by Molmil
Crystal Structure of Engineered Trimeric Cortexillin-1 Coiled-Coil Variant
Descriptor: Cortexillin-1, PHOSPHATE ION
Authors:Bjelic, S, Steinmetz, M.O, Kammerer, R.A.
Deposit date:2013-02-06
Release date:2013-05-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.6499 Å)
Cite:Structural basis for the oligomerization-state switch from a dimer to a trimer of an engineered cortexillin-1 coiled-coil variant.
Plos One, 8, 2013
2PTA
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BU of 2pta by Molmil
PANDINUS TOXIN K-A (PITX-KA) FROM PANDINUS IMPERATOR, NMR, 20 STRUCTURES
Descriptor: PANDINUS TOXIN K-ALPHA
Authors:Tenenholz, T.C, Rogowski, R.S, Collins, J.H, Blaustein, M.P, Weber, D.J.
Deposit date:1996-11-26
Release date:1997-12-10
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure for Pandinus toxin K-alpha (PiTX-K alpha), a selective blocker of A-type potassium channels.
Biochemistry, 36, 1997
3GJP
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BU of 3gjp by Molmil
Crystal structure of mutant coiled coil GCN4 leucine zipper
Descriptor: General control protein GCN4
Authors:Honnappa, S, Steinmetz, M.O.
Deposit date:2009-03-09
Release date:2010-03-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis of coiled-coil oligomerization-state specificity
Proc.Natl.Acad.Sci.USA, 107, 2010
2O7H
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BU of 2o7h by Molmil
Crystal structure of trimeric coiled coil GCN4 leucine zipper
Descriptor: General control protein GCN4
Authors:Jawhari, H, Honnappa, S, Steinmetz, M.O.
Deposit date:2006-12-11
Release date:2007-11-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Molecular basis of coiled-coil oligomerization-state specificity
Proc.Natl.Acad.Sci.USA, 107, 2010
1USR
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BU of 1usr by Molmil
Newcastle disease virus hemagglutinin-neuraminidase: Evidence for a second sialic acid binding site and implications for fusion
Descriptor: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 2-acetamido-2-deoxy-alpha-D-glucopyranose, CALCIUM ION, ...
Authors:Zaitsev, V, Von Itzstein, M, Groves, D, Kiefel, M, Takimoto, T, Portner, A, Taylor, G.
Deposit date:2003-11-28
Release date:2004-01-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Second Sialic Acid Binding Site in Newcastle Disease Virus Hemagglutinin-Neuraminidase: Implications for Fusion
J.Virol., 78, 2004
2PZI
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BU of 2pzi by Molmil
Crystal Structure of Protein kinase PknG from Mycobacterium tuberculosis in Complex with Tetrahydrobenzothiophene AX20017
Descriptor: 2-[(CYCLOPROPYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE, CADMIUM ION, CHLORIDE ION, ...
Authors:Honnappa, S, Steinmetz, M.O.
Deposit date:2007-05-18
Release date:2007-07-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.Usa, 104, 2007
4I50
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BU of 4i50 by Molmil
Crystal structure of tubulin-stathmin-TTL-Epothilone A complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ...
Authors:Prota, A.E, Bargsten, K, Zurwerra, D, Field, J.J, Diaz, J.F, Altmann, K.H, Steinmetz, M.O.
Deposit date:2012-11-28
Release date:2013-01-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents.
Science, 339, 2013
1FVV
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BU of 1fvv by Molmil
THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR
Descriptor: 4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE, CYCLIN A, CYCLIN-DEPENDENT KINASE 2
Authors:Davis, S.T, Benson, B.G, Bramson, H.N, Chapman, D.E, Dickerson, S.H, Dold, K.M, Eberwein, D.J, Edelstein, M, Frye, S.V, Gampe Jr, R.T, Griffin, R.J, Harris, P.A, Hassell, A.M, Holmes, W.D, Hunter, R.N, Knick, V.B, Lackey, K, Lovejoy, B, Luzzio, M.J, Murray, D, Parker, P, Rocque, W.J, Shewchuk, L, Veal, J.M, Walker, D.H, Kuyper, L.K.
Deposit date:2000-09-20
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors.
Science, 291, 2001
2L56
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BU of 2l56 by Molmil
NMR structure of the GCN4 trigger peptide refined using biased molecular dynamics simulations
Descriptor: General control protein GCN4
Authors:Missimer, J.H, Dolenc, J, Steinmetz, M.O, van Gunsteren, W.F.
Deposit date:2010-10-26
Release date:2010-12-01
Last modified:2011-10-26
Method:SOLUTION NMR
Cite:Exploring the trigger sequence of the GCN4 coiled-coil: Biased molecular dynamics resolves apparent inconsistencies in NMR measurements
Protein Sci., 19, 2010
4IHJ
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BU of 4ihj by Molmil
Crystal structure of tubulin-stathmin-TTL-ADP complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ...
Authors:Prota, A.E, Magiera, M.M, Kuijpers, M, Bargsten, K, Frey, D, Wieser, M, Jaussi, R, Hoogenraad, C.C, Kammerer, R.A, Janke, C, Steinmetz, M.O.
Deposit date:2012-12-18
Release date:2013-02-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of tubulin tyrosination by tubulin tyrosine ligase.
J.Cell Biol., 200, 2013
1FVT
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BU of 1fvt by Molmil
THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH AN OXINDOLE INHIBITOR
Descriptor: 4-[(2Z)-2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazinyl]benzene-1-sulfonamide, CELL DIVISION PROTEIN KINASE 2
Authors:Davis, S.T, Benson, B.G, Bramson, H.N, Chapman, D.E, Dickerson, S.H, Dold, K.M, Eberwein, D.J, Edelstein, M, Frye, S.V, Gampe Jr, R.T, Griffin, R.J, Harris, P.A, Hassell, A.M, Holmes, W.D, Hunter, R.N, Knick, V.B, Lackey, K, Lovejoy, B, Luzzio, M.J, Murray, D, Parker, P, Rocque, W.J, Shewchuk, L, Veal, J.M, Walker, D.H, Kuyper, L.K.
Deposit date:2000-09-20
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors.
Science, 291, 2001
1WU9
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BU of 1wu9 by Molmil
Crystal structure of the C-terminal domain of the end-binding protein 1 (EB1)
Descriptor: Microtubule-associated protein RP/EB family member 1
Authors:Honnappa, S, John, C.M, Kostrewa, D, Winkler, F.K, Steinmetz, M.O.
Deposit date:2004-12-02
Release date:2005-02-01
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Structural insights into the EB1-APC interaction
Embo J., 24, 2005

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