3UTZ

Endogenous-like inhibitory antibodies targeting activated metalloproteinase motifs show therapeutic potential

Summary for 3UTZ

Entry DOI	10.2210/pdb3utz/pdb
Descriptor	Metalloproteinase, light chain, Metalloproteinase, heavy chain, SULFATE ION, ... (4 entities in total)
Functional Keywords	structural genomics, israel structural proteomics center, ispc, fab domain, immune system
Biological source	Mus musculus (mouse) More
Total number of polymer chains	6
Total formula weight	145452.28
Authors	Sela-Passwell, N.,Kikkeri, R.,Dym, O.,Rozenberg, H.,Margalit, R.,Arad-Yellin, R.,Eisenstein, M.,Brenner, O.,Shoham, T.,Danon, T.,Shanzer, A.,Sagi, I.,Israel Structural Proteomics Center (ISPC) (deposition date: 2011-11-27, release date: 2011-12-14, Last modification date: 2017-03-15)
Primary citation	Sela-Passwell, N.,Kikkeri, R.,Dym, O.,Rozenberg, H.,Margalit, R.,Arad-Yellin, R.,Eisenstein, M.,Brenner, O.,Shoham, T.,Danon, T.,Shanzer, A.,Sagi, I. Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential. NAT.MED. (N.Y.), 18:143-147, 2012 Cited by PubMed: 22198278 DOI: 10.1038/nm.2582 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.18 Å)

Structure validation