4I50
Crystal structure of tubulin-stathmin-TTL-Epothilone A complex
Summary for 4I50
Entry DOI | 10.2210/pdb4i50/pdb |
Related | 4I4T 4I55 4IHJ 4IIJ |
Descriptor | Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (14 entities in total) |
Functional Keywords | alpha-tubulin, beta-tubulin, ligase, gtpase, microtubule, stathmin, epothilone a, cell cycle |
Biological source | Rattus norvegicus (brown rat,rat,rats) More |
Cellular location | Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 265651.46 |
Authors | Prota, A.E.,Bargsten, K.,Zurwerra, D.,Field, J.J.,Diaz, J.F.,Altmann, K.H.,Steinmetz, M.O. (deposition date: 2012-11-28, release date: 2013-01-23, Last modification date: 2023-09-20) |
Primary citation | Prota, A.E.,Bargsten, K.,Zurwerra, D.,Field, J.J.,Diaz, J.F.,Altmann, K.H.,Steinmetz, M.O. Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents. Science, 339:587-590, 2013 Cited by PubMed: 23287720DOI: 10.1126/science.1230582 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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