4I50

Crystal structure of tubulin-stathmin-TTL-Epothilone A complex

Summary for 4I50

• Entry DOI: 10.2210/pdb4i50/pdb
• Related: 4I4T 4I55 4IHJ 4IIJ
• Descriptor: Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (14 entities in total)
• Functional Keywords: alpha-tubulin, beta-tubulin, ligase, gtpase, microtubule, stathmin, epothilone a, cell cycle
• Biological source: Rattus norvegicus (brown rat,rat,rats); More
• Cellular location: Cytoplasm, cytoskeleton: P81947 Q6B856; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 265651.46

Authors

Prota, A.E.,Bargsten, K.,Zurwerra, D.,Field, J.J.,Diaz, J.F.,Altmann, K.H.,Steinmetz, M.O. (deposition date: 2012-11-28, release date: 2013-01-23, Last modification date: 2023-09-20)

• Primary citation: Prota, A.E.,Bargsten, K.,Zurwerra, D.,Field, J.J.,Diaz, J.F.,Altmann, K.H.,Steinmetz, M.O.; Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents.; Science, 339:587-590, 2013; PubMed: 23287720; DOI: 10.1126/science.1230582

Experimental method

X-RAY DIFFRACTION (2.3 Å)