4K45
 
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1TAD
 | | GTPASE MECHANISM OF GPROTEINS FROM THE 1.7-ANGSTROM CRYSTAL STRUCTURE OF TRANSDUCIN ALPHA-GDP-ALF4- | | Descriptor: | CACODYLATE ION, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Sondek, J, Lambright, D.G, Noel, J.P, Hamm, H.E, Sigler, P.B. | | Deposit date: | 1995-01-05 | | Release date: | 1995-05-08 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4.
Nature, 372, 1994
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2ZKM
 | | Crystal Structure of Phospholipase C Beta 2 | | Descriptor: | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2, CALCIUM ION | | Authors: | Hicks, S.N, Jezyk, M.R, Gershberg, S, Seifert, J.P, Harden, T.K, Sondek, J. | | Deposit date: | 2008-03-26 | | Release date: | 2008-08-12 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | General and versatile autoinhibition of PLC isozymes
Mol.Cell, 31, 2008
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7T8T
 | | CryoEM structure of PLCg1 | | Descriptor: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, CALCIUM ION | | Authors: | Endo-Streeter, S, Sondek, J. | | Deposit date: | 2021-12-17 | | Release date: | 2022-12-21 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.68 Å) | | Cite: | CryoEM structure of PLCg1
To Be Published
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3GRE
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6PBC
 | | Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations | | Descriptor: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, SODIUM ION | | Authors: | Hajicek, N, Sondek, J. | | Deposit date: | 2019-06-13 | | Release date: | 2020-01-08 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.46 Å) | | Cite: | Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations.
Elife, 8, 2019
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1GOT
 | | HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS | | Descriptor: | GT-ALPHA/GI-ALPHA CHIMERA, GT-BETA, GT-GAMMA, ... | | Authors: | Lambright, D.G, Sondek, J, Bohm, A, Skiba, N.P, Hamm, H.E, Sigler, P.B. | | Deposit date: | 1996-08-07 | | Release date: | 1997-03-12 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The 2.0 A crystal structure of a heterotrimeric G protein.
Nature, 379, 1996
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7SQ2
 | | Reprocessed and refined structure of Phospholipase C-beta and Gq signaling complex | | Descriptor: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, ACETATE ION, CALCIUM ION, ... | | Authors: | Endo-Streeter, S.T, Sondek, J, Harden, T.K. | | Deposit date: | 2021-11-04 | | Release date: | 2021-11-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Kinetic Scaffolding Mediated by a Phospholipase C-{beta} and Gq Signaling Complex
Science, 330, 2010
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1Y3A
 | | Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... | | Authors: | Johnston, C.A, Willard, F.S, Jezyk, M.R, Fredericks, Z, Bodor, E.T, Jones, M.B, Blaesius, R, Harden, T.K, Sondek, J, Watts, V.J, Ramer, J.K, Siderovski, D.P. | | Deposit date: | 2004-11-24 | | Release date: | 2005-07-12 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
Structure, 7, 2005
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1XO5
 | | Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein | | Descriptor: | CALCIUM ION, Calcium and integrin-binding protein 1 | | Authors: | Gentry, H.R, Singer, A.U, Betts, L, Yang, C, Ferrara, J.D, Parise, L.V, Sondek, J. | | Deposit date: | 2004-10-05 | | Release date: | 2004-12-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Structural and Biochemical Characterization of CIB1 Delineates a New Family of EF-hand-containing Proteins
J.Biol.Chem., 280, 2005
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4K44
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2FJU
 | | Activated Rac1 bound to its effector phospholipase C beta 2 | | Descriptor: | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, CALCIUM ION, ... | | Authors: | Jezyk, M.R, Snyder, J.T, Harden, T.K, Sondek, J. | | Deposit date: | 2006-01-03 | | Release date: | 2006-11-21 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of Rac1 bound to its effector phospholipase C-beta2.
Nat.Struct.Mol.Biol., 13, 2006
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1FOE
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2NZ8
 | | N-terminal DHPH cassette of Trio in complex with nucleotide-free Rac1 | | Descriptor: | ras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein | | Authors: | Chhatriwala, M.K, Betts, L, Worthylake, D.K, Sondek, J. | | Deposit date: | 2006-11-22 | | Release date: | 2007-04-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
J.Mol.Biol., 368, 2007
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2PBI
 | | The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure | | Descriptor: | GLYCEROL, Guanine nucleotide-binding protein subunit beta 5, Regulator of G-protein signaling 9 | | Authors: | Cheever, M.L, Snyder, J.T, Gershburg, S, Siderovski, D.P, Harden, T.K, Sondek, J. | | Deposit date: | 2007-03-28 | | Release date: | 2008-01-29 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structure of the multifunctional Gbeta5-RGS9 complex.
Nat.Struct.Mol.Biol., 15, 2008
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1IHJ
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2NUD
 | | The structure of the type III effector AvrB complexed with a high-affinity RIN4 peptide | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Avirulence B protein, RPM1-interacting protein 4, ... | | Authors: | Singer, A.U, Desveaux, D, Wu, A.J, McNulty, B, Sondek, J, Dangl, J.L. | | Deposit date: | 2006-11-09 | | Release date: | 2007-05-22 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction.
Plos Pathog., 3, 2007
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2NUN
 | | The structure of the type III effector AvrB complexed with ADP | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Avirulence B protein | | Authors: | Singer, A.U, Desveaux, D, Wu, A.J, McNulty, B, Dangl, J.L, Sondek, J. | | Deposit date: | 2006-11-09 | | Release date: | 2007-05-22 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction.
Plos Pathog., 3, 2007
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1KZ7
 | | Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42 | | Descriptor: | CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS | | Authors: | Rossman, K.L, Worthylake, D.K, Snyder, J.T, Siderovski, D.P, Campbell, S.L, Sondek, J. | | Deposit date: | 2002-02-06 | | Release date: | 2002-03-20 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
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1KZG
 | | DbsCdc42(Y889F) | | Descriptor: | CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS | | Authors: | Rossman, K.L, Worthylake, D.K, Snyder, J.T, Siderovski, D.P, Campbell, S.L, Sondek, J. | | Deposit date: | 2002-02-06 | | Release date: | 2002-03-20 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
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2PZ1
 | | Crystal Structure of Auto-inhibited Asef | | Descriptor: | Rho guanine nucleotide exchange factor 4 | | Authors: | Betts, L, Sondek, J, Rossman, K.L. | | Deposit date: | 2007-05-17 | | Release date: | 2007-08-21 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Nat.Struct.Mol.Biol., 14, 2007
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1S28
 | | Crystal Structure of AvrPphF ORF1, the Chaperone for the Type III Effector AvrPphF ORF2 from P. syringae | | Descriptor: | ORF1, SULFATE ION | | Authors: | Singer, A.U, Desveaux, D, Betts, L, Chang, J.H, Nimchuk, Z, Grant, S.R, Dangl, J.L, Sondek, J. | | Deposit date: | 2004-01-08 | | Release date: | 2004-09-14 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal Structures of the Type III Effector Protein AvrPphF and Its Chaperone Reveal Residues Required for Plant Pathogenesis
Structure, 12, 2004
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1S21
 | | Crystal Structure of AvrPphF ORF2, A Type III Effector from P. syringae | | Descriptor: | ORF2 | | Authors: | Singer, A.U, Desveaux, D, Betts, L, Chang, J.H, Nimchuk, Z, Grant, S.R, Dangl, J.K, Sondek, J. | | Deposit date: | 2004-01-07 | | Release date: | 2004-09-14 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structures of the Type III Effector Protein AvrPphF and Its Chaperone Reveal Residues Required for Plant Pathogenesis
Structure, 12, 2004
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1RJ2
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1KI1
 | | Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42 | | Descriptor: | G25K GTP-binding protein, placental isoform, SULFATE ION, ... | | Authors: | Snyder, J.T, Pruitt, W.M, Der, C.J, Sondek, J. | | Deposit date: | 2001-12-02 | | Release date: | 2002-05-29 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
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