5E6D
 
 | | Glucocorticoid receptor DNA binding domain - ICAM1 NF-kB response element complex | | 分子名称: | DNA (5'-D(*GP*CP*TP*CP*CP*GP*GP*AP*AP*TP*TP*TP*CP*CP*AP*A)-3'), DNA (5'-D(*TP*TP*GP*GP*AP*AP*AP*TP*TP*CP*CP*GP*GP*AP*GP*C)-3'), Glucocorticoid receptor, ... | | 著者 | Hudson, W.H, Rye, E.A, Herbst, A.G, Ortlund, E.A. | | 登録日 | 2015-10-09 | | 公開日 | 2017-02-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
Nat Commun, 9, 2018
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4MCE
 | | Crystal structure of the Gas5 GRE Mimic | | 分子名称: | Gas5 GREM Fwd, Gas5 GREM Rev, SULFATE ION | | 著者 | Hudson, W.H, Ortlund, E.A. | | 登録日 | 2013-08-21 | | 公開日 | 2014-09-24 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.205 Å) | | 主引用文献 | Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.
Nat Commun, 5, 2014
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4MCF
 | | Crystal structure of the Gas5 GRE Mimic | | 分子名称: | Gas5 GREM Fwd, Gas5 GREM Rev, SULFATE ION | | 著者 | Hudson, W.H, Ortlund, E.A. | | 登録日 | 2013-08-21 | | 公開日 | 2014-11-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.899 Å) | | 主引用文献 | Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.
Nat Commun, 5, 2014
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4TNT
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1HRB
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7DCL
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7C7Z
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2FTM
 | | Crystal structure of trypsin complexed with the BPTI variant (Tyr35->Gly) | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, Cationic trypsin, ... | | 著者 | Hanson, W.M, Horvath, M.P, Goldenberg, D.P. | | 登録日 | 2006-01-24 | | 公開日 | 2006-02-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Rigidification of a Flexible Protease Inhibitor Variant upon Binding to Trypsin.
J.Mol.Biol., 366, 2007
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2FTL
 | | Crystal structure of trypsin complexed with BPTI at 100K | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, Cationic trypsin, ... | | 著者 | Hanson, W.M, Horvath, M.P, Goldenberg, D.P. | | 登録日 | 2006-01-24 | | 公開日 | 2006-02-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Rigidification of a Flexible Protease Inhibitor Variant upon Binding to Trypsin.
J.Mol.Biol., 366, 2007
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1KZF
 | | Crystal Structure of the Acyl-homoserine Lactone Synthase, EsaI | | 分子名称: | acyl-homoserinelactone synthase EsaI | | 著者 | Watson, W.T, Minogue, T.D, Val, D.L, Beck von Bodman, S, Churchill, M.E.A. | | 登録日 | 2002-02-06 | | 公開日 | 2002-04-17 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis and specificity of acyl-homoserine lactone signal production in bacterial quorum sensing.
Mol.Cell, 9, 2002
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4HN6
 | | GR DNA Binding Domain R460D/D462R - TSLP nGRE Complex | | 分子名称: | DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), Glucocorticoid receptor, ... | | 著者 | Hudson, W.H, Youn, C.E, Ortlund, E.A. | | 登録日 | 2012-10-18 | | 公開日 | 2012-12-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.549 Å) | | 主引用文献 | The structural basis of direct glucocorticoid-mediated transrepression.
Nat.Struct.Mol.Biol., 20, 2013
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4HN5
 | | GR DNA Binding Domain - TSLP nGRE Complex | | 分子名称: | DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), Glucocorticoid receptor, ... | | 著者 | Hudson, W.H, Youn, C.E, Ortlund, E.A. | | 登録日 | 2012-10-18 | | 公開日 | 2012-12-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.902 Å) | | 主引用文献 | The structural basis of direct glucocorticoid-mediated transrepression.
Nat.Struct.Mol.Biol., 20, 2013
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1APX
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1CRN
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1MLD
 | | REFINED STRUCTURE OF MITOCHONDRIAL MALATE DEHYDROGENASE FROM PORCINE HEART AND THE CONSENSUS STRUCTURE FOR DICARBOXYLIC ACID OXIDOREDUCTASES | | 分子名称: | CITRIC ACID, MALATE DEHYDROGENASE | | 著者 | Gleason, W.B, Fu, Z, Birktoft, J.J, Banaszak, L.J. | | 登録日 | 1994-01-24 | | 公開日 | 1995-01-26 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Refined crystal structure of mitochondrial malate dehydrogenase from porcine heart and the consensus structure for dicarboxylic acid oxidoreductases.
Biochemistry, 33, 1994
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8R5J
 | | Crystal structure of MERS-CoV main protease | | 分子名称: | Non-structural protein 11 | | 著者 | Balcomb, B.H, Fairhead, M, Koekemoer, L, Lithgo, R.M, Aschenbrenner, J.C, Chandran, A.V, Godoy, A.S, Lukacik, P, Marples, P.G, Mazzorana, M, Ni, X, Strain-Damerell, C, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Fearon, D, Walsh, M.A, von Delft, F. | | 登録日 | 2023-11-16 | | 公開日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.898 Å) | | 主引用文献 | Crystal structure of MERS-CoV main protease
To Be Published
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4EWQ
 | | Human p38 alpha MAPK in complex with a pyridazine based inhibitor | | 分子名称: | 3-phenyl-4-(pyridin-4-yl)-6-[4-(pyrimidin-2-yl)piperazin-1-yl]pyridazine, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, ACETATE ION, ... | | 著者 | Grum-Tokars, V, Minasov, G, Roy, S, Schavocky, J, Winsor, J, Watterson, D.M, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2012-04-27 | | 公開日 | 2012-06-27 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A Selective and Brain Penetrant p38 alpha MAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.
J.Med.Chem., 62, 2019
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1G9M
 | | HIV-1 HXBC2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, HEAVY CHAIN, ... | | 著者 | Kwong, P.D, Wyatt, R, Majeed, S, Robinson, J, Sweet, R.W, Sodroski, J, Hendrickson, W.A. | | 登録日 | 2000-11-24 | | 公開日 | 2000-12-27 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates.
Structure Fold.Des., 8, 2000
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1G9N
 | | HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, HEAVY CHAIN, ... | | 著者 | Kwong, P.D, Wyatt, R, Majeed, S, Robinson, J, Sweet, R.W, Sodroski, J, Hendrickson, W.A. | | 登録日 | 2000-11-25 | | 公開日 | 2000-12-27 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates.
Structure Fold.Des., 8, 2000
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1GC1
 | | HIV-1 GP120 CORE COMPLEXED WITH CD4 AND A NEUTRALIZING HUMAN ANTIBODY | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, CD4, ... | | 著者 | Kwong, P.D, Wyatt, R, Robinson, J, Sweet, R.W, Sodroski, J, Hendrickson, W.A. | | 登録日 | 1998-06-15 | | 公開日 | 1998-07-08 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.
Nature, 393, 1998
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8B16
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4EGU
 | | 0.95A Resolution Structure of a Histidine Triad Protein from Clostridium difficile | | 分子名称: | GUANOSINE-5'-MONOPHOSPHATE, POTASSIUM ION, ZINC ION, ... | | 著者 | Anderson, S.M, Wawrzak, Z, Kudritska, M, Peterson, S.N, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2012-04-01 | | 公開日 | 2012-04-18 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | | 主引用文献 | 0.95A Resolution Structure of a Histidine Triad Protein from Clostridium difficile
To be Published
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3GEU
 | | Crystal Structure of IcaR from Staphylococcus aureus, a member of the tetracycline repressor protein family | | 分子名称: | CHLORIDE ION, FORMIC ACID, Intercellular adhesion protein R, ... | | 著者 | Anderson, S.M, Brunzelle, J.S, Wawrzak, Z, Skarina, T, Papazisi, L, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2009-02-26 | | 公開日 | 2009-03-10 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal Structure of IcaR from Staphylococcus aureus, a member of the tetracycline repressor protein family
To be Published
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3FF1
 | | Structure of Glucose 6-phosphate Isomerase from Staphylococcus aureus | | 分子名称: | GLUCOSE-6-PHOSPHATE, Glucose-6-phosphate isomerase, SODIUM ION | | 著者 | Anderson, S.M, Brunzelle, J.S, Onopriyenko, O, Peterson, S, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2008-12-01 | | 公開日 | 2009-02-03 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structure of Glucose 6-phosphate Isomerase from Staphylococcus aureus
TO BE PUBLISHED
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5HM3
 | | 2.25 Angstrom Resolution Crystal Structure of Long-chain-fatty-acid-AMP Ligase FadD32 from Mycobacterium tuberculosis in complex with Inhibitor 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine | | 分子名称: | 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Minasov, G, Warwrzak, Z, Kuhn, M.L, Shuvalova, L, Flores, K.J, Wilson, D.J, Grimes, K.D, Aldrich, C.C, Anderson, W.A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2016-01-15 | | 公開日 | 2016-08-03 | | 最終更新日 | 2016-09-07 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis.
Acs Infect Dis., 2, 2016
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