1G9N

HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B

Summary for 1G9N

• Entry DOI: 10.2210/pdb1g9n/pdb
• Related: 1g9m
• Descriptor: ENVELOPE GLYCOPROTEIN GP120, T-CELL SURFACE GLYCOPROTEIN CD4, ANTIBODY 17B, LIGHT CHAIN, ... (6 entities in total)
• Functional Keywords: complex (hiv envelope protein-cd4-fab), hiv-1 exterior envelope gp120 from clinical primary isolate, yu2, t-cell surface glycoprotein cd4, antigen-binding fragment of human immunoglobulin 17b, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 4
• Total formula weight: 106404.40

Authors

Kwong, P.D.,Wyatt, R.,Majeed, S.,Robinson, J.,Sweet, R.W.,Sodroski, J.,Hendrickson, W.A. (deposition date: 2000-11-25, release date: 2000-12-27, Last modification date: 2024-11-06)

Primary citation

Kwong, P.D.,Wyatt, R.,Majeed, S.,Robinson, J.,Sweet, R.W.,Sodroski, J.,Hendrickson, W.A.
Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates.
Structure Fold.Des., 8:1329-1339, 2000

PubMed Abstract: The gp120 exterior envelope glycoprotein of HIV-1 binds sequentially to CD4 and chemokine receptors on cells to initiate virus entry. During natural infection, gp120 is a primary target of the humoral immune response, and it has evolved to resist antibody-mediated neutralization. We previously reported the structure at 2.5 A of a gp120 core from the HXBc2 laboratory-adapted isolate in complex with a 2 domain fragment of CD4 and the antigen binding fragment of a human antibody. This revealed atomic details of gp120-receptor interactions and suggested multiple mechanisms of immune evasion.

PubMed: 11188697
DOI: 10.1016/S0969-2126(00)00547-5

Experimental method

X-RAY DIFFRACTION (2.9 Å)