3ML6
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![BU of 3ml6 by Molmil](/molmil-images/mine/3ml6) | a complex between Dishevelled2 and clathrin adaptor AP-2 | Descriptor: | Chimeric complex between protein Dishevelled2 homolog dvl-2 and clathrin adaptor AP-2 complex subunit mu | Authors: | Yu, A, Xing, Y, Harrison, S.C, Kirchhausen, T.L. | Deposit date: | 2010-04-16 | Release date: | 2010-08-11 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. Structure, 18, 2010
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5T51
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![BU of 5t51 by Molmil](/molmil-images/mine/5t51) | Structure of the MIND Complex Shows a Regulatory Focus of Yeast Kinetochore Assembly | Descriptor: | KLLA0E05809p, KLLA0F02343p, SULFATE ION | Authors: | Dimitrova, Y, Jenni, S, Valverde, R, Khin, Y, Harrison, S.C. | Deposit date: | 2016-08-30 | Release date: | 2016-11-09 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.2007 Å) | Cite: | Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly. Cell, 167, 2016
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5T59
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![BU of 5t59 by Molmil](/molmil-images/mine/5t59) | Structure of the MIND Complex Shows a Regulatory Focus of Yeast Kinetochore Assembly | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, KLLA0B13629p, KLLA0E05809p, ... | Authors: | Dimitrova, Y, Jenni, S, Valverde, R, Khin, Y, Harrison, S.C. | Deposit date: | 2016-08-30 | Release date: | 2016-11-09 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.405 Å) | Cite: | Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly. Cell, 167, 2016
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5T6J
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![BU of 5t6j by Molmil](/molmil-images/mine/5t6j) | Structure of the MIND Complex Shows a Regulatory Focus of Yeast Kinetochore Assembly | Descriptor: | Kinetochore protein SPC24, Kinetochore protein SPC25, Kinetochore-associated protein DSN1 | Authors: | Valverde, R, Jenni, S, Dimitrova, Y, Khin, Y, Harrison, S.C. | Deposit date: | 2016-09-01 | Release date: | 2016-11-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.752 Å) | Cite: | Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly. Cell, 167, 2016
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2KT5
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![BU of 2kt5 by Molmil](/molmil-images/mine/2kt5) | RRM domain of mRNA export adaptor REF2-I bound to HSV-1 ICP27 peptide | Descriptor: | ICP27, RNA and export factor-binding protein 2 | Authors: | Tunnicliffe, N.B, Golovanov, A.P, Wilson, S.A, Hautbergue, G.M. | Deposit date: | 2010-01-18 | Release date: | 2011-01-12 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural Basis for the Recognition of Cellular mRNA Export Factor REF by Herpes Viral Proteins HSV-1 ICP27 and HVS ORF57. Plos Pathog., 7, 2011
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2P66
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![BU of 2p66 by Molmil](/molmil-images/mine/2p66) | Human DNA Polymerase beta complexed with tetrahydrofuran (abasic site) containing DNA | Descriptor: | DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3'), DNA (5'-D(P*(3DR)P*GP*TP*CP*GP*G)-3'), ... | Authors: | Prasad, R, Batra, V.K, Yang, X.-P, Krahn, J.M, Pedersen, L.C, Beard, W.A, Wilson, S.H. | Deposit date: | 2007-03-16 | Release date: | 2007-04-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural insight into the DNA Polymerase beta deoxyribose phosphate lyase mechanism DNA REPAIR, 4, 2005
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5F4N
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![BU of 5f4n by Molmil](/molmil-images/mine/5f4n) | Multi-parameter lead optimization to give an oral CHK1 inhibitor clinical candidate: (R)-5-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737) | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Serine/threonine-protein kinase Chk1, ... | Authors: | Collins, I, Garrett, M.D, van Montfort, R, Osborne, J.D, Matthews, T.P, McHardy, T, Proisy, N, Cheung, K.J, Lainchbury, M, Brown, N, Walton, M.I, Eve, P.D, Boxall, K.J, Hayes, A, Henley, A.T, Valenti, M.R, De Haven Brandon, A.K, Box, G, Westwood, I.M, Jamin, Y, Robinson, S.P, Leonard, P, Reader, J.C, Aherne, G.W, Raynaud, F.I, Eccles, S.A. | Deposit date: | 2015-12-03 | Release date: | 2016-05-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737). J.Med.Chem., 59, 2016
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4IT3
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![BU of 4it3 by Molmil](/molmil-images/mine/4it3) | Crystal Structure of Iml3 from S. cerevisiae | Descriptor: | Central kinetochore subunit IML3 | Authors: | Hinshaw, S.M, Harrison, S.C. | Deposit date: | 2013-01-17 | Release date: | 2013-10-16 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.495 Å) | Cite: | An iml3-chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation. Cell Rep, 5, 2013
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5F4B
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![BU of 5f4b by Molmil](/molmil-images/mine/5f4b) | Structure of B. abortus WrbA-related protein A (WrpA) | Descriptor: | CHLORIDE ION, FLAVIN MONONUCLEOTIDE, NAD(P)H dehydrogenase (quinone) | Authors: | Herrou, J, Czyz, D, Willett, J.W, Kim, H.S, Chhor, G, Endres, M, Babnigg, G, Kim, Y, Joachimiak, A, Crosson, S, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2015-12-03 | Release date: | 2016-03-09 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.498 Å) | Cite: | WrpA Is an Atypical Flavodoxin Family Protein under Regulatory Control of the Brucella abortus General Stress Response System. J.Bacteriol., 198, 2016
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5F51
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![BU of 5f51 by Molmil](/molmil-images/mine/5f51) | Structure of B. abortus WrbA-related protein A (apo) | Descriptor: | NAD(P)H dehydrogenase (quinone), SULFATE ION | Authors: | Herrou, J, Czyz, D, Willett, J.W, Kim, H.S, Kim, Y, Crosson, S. | Deposit date: | 2015-12-03 | Release date: | 2016-03-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | WrpA Is an Atypical Flavodoxin Family Protein under Regulatory Control of the Brucella abortus General Stress Response System. J.Bacteriol., 198, 2016
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4JE3
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![BU of 4je3 by Molmil](/molmil-images/mine/4je3) | |
5UG0
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![BU of 5ug0 by Molmil](/molmil-images/mine/5ug0) | Human antibody H2897 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2897 heavy chain, ... | Authors: | Raymond, D.D, Caradonna, T, Schmidt, A.G, Harrison, S.C. | Deposit date: | 2017-01-06 | Release date: | 2017-05-31 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. J. Mol. Biol., 429, 2017
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3T0Y
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![BU of 3t0y by Molmil](/molmil-images/mine/3t0y) | |
2WLV
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![BU of 2wlv by Molmil](/molmil-images/mine/2wlv) | Structure of the N-terminal capsid domain of HIV-2 | Descriptor: | GAG POLYPROTEIN | Authors: | Price, A.J, Marzetta, F, Lammers, M, Ylinen, L.M.J, Schaller, T, Wilson, S.J, Towers, G.J, James, L.C. | Deposit date: | 2009-06-26 | Release date: | 2009-09-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Active Site Remodelling Switches HIV Specificity of Antiretroviral Trimcyp Nat.Struct.Mol.Biol., 16, 2009
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5GJE
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![BU of 5gje by Molmil](/molmil-images/mine/5gje) | Three-dimensional reconstruction of human LRP6 ectodomain complexed with Dkk1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Matoba, K, Mihara, E, Tamura-Kawakami, K, Hirai, H, Thompson, S, Iwasaki, K, Takagi, J. | Deposit date: | 2016-06-29 | Release date: | 2017-01-18 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (21 Å) | Cite: | Conformational Freedom of the LRP6 Ectodomain Is Regulated by N-glycosylation and the Binding of the Wnt Antagonist Dkk1 Cell Rep, 18, 2017
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5FSR
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![BU of 5fsr by Molmil](/molmil-images/mine/5fsr) | Crystal structure of penicillin binding protein 6B from Escherichia coli | Descriptor: | D-ALANYL-D-ALANINE CARBOXYPEPTIDASE DACD | Authors: | Peters, K, Kannan, S, Rao, V.A, Bilboy, J, Vollmer, D, Erickson, S.W, Lewis, R.J, Young, K.D, Vollmer, W. | Deposit date: | 2016-01-07 | Release date: | 2016-06-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The Redundancy of Peptidoglycan Carboxypeptidases Ensures Robust Cell Shape Maintenance in Escherichia Coli Mbio, 7, 2016
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7LFH
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![BU of 7lfh by Molmil](/molmil-images/mine/7lfh) | |
4JV9
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![BU of 4jv9 by Molmil](/molmil-images/mine/4jv9) | Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one | Descriptor: | (2S,5R,6S)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | Authors: | Huang, X, Gonzalez-Lopez de Turiso, F, Sun, D, Yosup, R, Bartberger, M.D, Beck, H.P, Cannon, J, Shaffer, P, Oliner, J.D, Olson, S.H, Medina, J.C. | Deposit date: | 2013-03-25 | Release date: | 2013-05-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors. J.Med.Chem., 56, 2013
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4PVL
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![BU of 4pvl by Molmil](/molmil-images/mine/4pvl) | X-ray structure of human transthyretin (TTR) at room temperature to 1.9A resolution | Descriptor: | Transthyretin | Authors: | Fisher, S.J, Blakeley, M.P, Haupt, M, Mason, S.A, Cooper, J.B, Mitchell, E.P, Forsyth, V.T. | Deposit date: | 2014-03-18 | Release date: | 2014-11-12 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.851 Å) | Cite: | Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein IUCrJ, 1, 2014
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4JV7
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![BU of 4jv7 by Molmil](/molmil-images/mine/4jv7) | Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one | Descriptor: | (2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | Authors: | Huang, X, Gonzalez-Lopez de Turiso, F, Sun, D, Yosup, R, Bartberger, M.D, Beck, H.P, Cannon, J, Shaffer, P, Oliner, J.D, Olson, S.H, Medina, J.C. | Deposit date: | 2013-03-25 | Release date: | 2013-05-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors. J.Med.Chem., 56, 2013
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5W6C
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![BU of 5w6c by Molmil](/molmil-images/mine/5w6c) | UCA Fab (unbound) from 6649 Lineage | Descriptor: | UCA Fab heavy chain, UCA Fab light chain | Authors: | Raymond, D.D, Harrison, S.C. | Deposit date: | 2017-06-16 | Release date: | 2017-12-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.634 Å) | Cite: | Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4JGJ
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![BU of 4jgj by Molmil](/molmil-images/mine/4jgj) | Crystal structure of the Ig-like D1 domain from mouse Carcinoembryogenic antigen-related cell adhesion molecule 15 (CEACAM15) [PSI-NYSGRC-005691] | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Carcinoembryonic antigen-related cell adhesion molecule 15, Unknown peptide | Authors: | Kumar, P.R, Bonanno, J, Ahmed, M, Banu, R, Bhosle, R, Calarese, D, Celikigil, A, Chamala, S, Chan, M.K, Chowdhury, S, Fiser, A, Garforth, S, Glenn, A.S, Hillerich, B, Khafizov, K, Love, J, Patel, H, Seidel, R, Stead, M, Toro, R, Nathenson, S.G, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) | Deposit date: | 2013-03-01 | Release date: | 2013-03-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6508 Å) | Cite: | Crystal structure of the Ig-like D1 domain of CEACAM15 from Mus musculus [NYSGRC-005691] to be published
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4GWA
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![BU of 4gwa by Molmil](/molmil-images/mine/4gwa) | Crystal Structure of a GH7 Family Cellobiohydrolase from Limnoria quadripunctata | Descriptor: | GH7 family protein, MAGNESIUM ION | Authors: | McGeehan, J.E, Martin, R.N.A, Streeter, S.D, Cragg, S.M, Guille, M.J, Schnorr, K.M, Kern, M, Bruce, N.C, McQueen-Mason, S.J. | Deposit date: | 2012-09-01 | Release date: | 2013-06-12 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural characterization of a unique marine animal family 7 cellobiohydrolase suggests a mechanism of cellulase salt tolerance Proc.Natl.Acad.Sci.USA, 110, 2013
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4HAP
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![BU of 4hap by Molmil](/molmil-images/mine/4hap) | Crystal Structure of a GH7 family cellobiohydrolase from Limnoria quadripunctata in complex with cellobiose | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, GH7 family protein, ... | Authors: | Martin, R.N.A, McGeehan, J.E, Streeter, S.D, Cragg, S.M, Guille, M.J, Schnorr, K.M, Kern, M, Bruce, N.C, McQueen-Mason, S.J. | Deposit date: | 2012-09-27 | Release date: | 2013-06-12 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural characterization of a unique marine animal family 7 cellobiohydrolase suggests a mechanism of cellulase salt tolerance Proc.Natl.Acad.Sci.USA, 110, 2013
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4JVE
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![BU of 4jve by Molmil](/molmil-images/mine/4jve) | Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid | Descriptor: | (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid, E3 ubiquitin-protein ligase Mdm2 | Authors: | Huang, X, Gonzalez-Lopez de Turiso, F, Sun, D, Yosup, R, Bartberger, M.D, Beck, H.P, Cannon, J, Shaffer, P, Oliner, J.D, Olson, S.H, Medina, J.C. | Deposit date: | 2013-03-25 | Release date: | 2013-05-01 | Last modified: | 2013-06-05 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors. J.Med.Chem., 56, 2013
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