2P66

Human DNA Polymerase beta complexed with tetrahydrofuran (abasic site) containing DNA

Summary for 2P66

• Entry DOI: 10.2210/pdb2p66/pdb
• Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3'), DNA (5'-D(P*(3DR)P*GP*TP*CP*GP*G)-3'), ... (7 entities in total)
• Functional Keywords: dna repair, base excision repair, drp lyase, transferase, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P06746
• Total number of polymer chains: 4
• Total formula weight: 48325.09

Authors

Prasad, R.,Batra, V.K.,Yang, X.-P.,Krahn, J.M.,Pedersen, L.C.,Beard, W.A.,Wilson, S.H. (deposition date: 2007-03-16, release date: 2007-04-10, Last modification date: 2023-08-30)

• Primary citation: Prasad, R.,Batra, V.K.,Yang, X.-P.,Krahn, J.M.,Pedersen, L.C.,Beard, W.A.,Wilson, S.H.; Structural insight into the DNA Polymerase beta deoxyribose phosphate lyase mechanism; DNA REPAIR, 4:1347-1357, 2005; PubMed: 16172026; DOI: 10.1016/j.dnarep.2005.08.009

Experimental method

X-RAY DIFFRACTION (2.5 Å)