4JV7

Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one

Summary for 4JV7

Related4JV9 4JVE 4JVR 4JWR
DescriptorE3 ubiquitin-protein ligase Mdm2, (2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one, SULFATE ION, ... (4 entities in total)
Functional Keywordsp53, protein-protein interaction, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleoplasm Q00987
Total number of polymer chains1
Total molecular weight11767.35
Authors
Huang, X.,Gonzalez-Lopez de Turiso, F.,Sun, D.,Yosup, R.,Bartberger, M.D.,Beck, H.P.,Cannon, J.,Shaffer, P.,Oliner, J.D.,Olson, S.H.,Medina, J.C. (deposition date: 2013-03-25, release date: 2013-05-01, Last modification date: 2013-06-05)
Primary citation
Gonzalez-Lopez de Turiso, F.,Sun, D.,Rew, Y.,Bartberger, M.D.,Beck, H.P.,Canon, J.,Chen, A.,Chow, D.,Correll, T.L.,Huang, X.,Julian, L.D.,Kayser, F.,Lo, M.C.,Long, A.M.,McMinn, D.,Oliner, J.D.,Osgood, T.,Powers, J.P.,Saiki, A.Y.,Schneider, S.,Shaffer, P.,Xiao, S.H.,Yakowec, P.,Yan, X.,Ye, Q.,Yu, D.,Zhao, X.,Zhou, J.,Medina, J.C.,Olson, S.H.
Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors.
J.Med.Chem., 56:4053-4070, 2013
PubMed: 23597064 (PDB entries with the same primary citation)
DOI: 10.1021/jm400293z
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.299903.8%2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4jv7
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Molmil generated image of 4jv7
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Molmil generated image of 4jv7
rotated about y axis by 90°