6P8G
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![BU of 6p8g by Molmil](/molmil-images/mine/6p8g) | Crystal structure of CDK4 in complex with CyclinD1 and P27 | Descriptor: | Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1B, G1/S-specific cyclin-D1 | Authors: | Guiley, K.Z, Stevenson, J.W, Lou, K, Barkovich, K.J, Bunch, K, Tripathi, S.M, Shokat, K.M, Rubin, S.M. | Deposit date: | 2019-06-07 | Release date: | 2019-12-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science, 366, 2019
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5C6D
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![BU of 5c6d by Molmil](/molmil-images/mine/5c6d) | Crystal structure of USP7 in complex with UHRF1 | Descriptor: | E3 ubiquitin-protein ligase UHRF1, Ubiquitin carboxyl-terminal hydrolase 7 | Authors: | Zhang, Z.-M, Song, J. | Deposit date: | 2015-06-22 | Release date: | 2015-09-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.292 Å) | Cite: | An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1. Cell Rep, 12, 2015
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6P8E
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![BU of 6p8e by Molmil](/molmil-images/mine/6p8e) | Crystal structure of CDK4 in complex with CyclinD1 and P27 | Descriptor: | Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1B, G1/S-specific cyclin-D1, ... | Authors: | Guiley, K.Z, Stevenson, J.W, Lou, K, Barkovich, K.J, Bunch, K, Tripathi, S.M, Shokat, K.M, Rubin, S.M. | Deposit date: | 2019-06-07 | Release date: | 2019-12-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science, 366, 2019
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4WS9
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![BU of 4ws9 by Molmil](/molmil-images/mine/4ws9) | Crystal structure of sMAT N159G from Sulfolobus solfataricus | Descriptor: | PHOSPHATE ION, S-adenosylmethionine synthase | Authors: | Wang, F, Brady, E.L, Singh, S, Clinger, J.A, Huber, T.D, Thorson, J.S, Phillips Jr, G.N. | Deposit date: | 2014-10-26 | Release date: | 2014-11-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.803 Å) | Cite: | Crystal structure of sMAT N159G from Sulfolobus solfataricus. To Be Published
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2VXO
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![BU of 2vxo by Molmil](/molmil-images/mine/2vxo) | Human GMP synthetase in complex with XMP | Descriptor: | GMP SYNTHASE [GLUTAMINE-HYDROLYZING], SULFATE ION, XANTHOSINE-5'-MONOPHOSPHATE | Authors: | Welin, M, Lehtio, L, Andersson, J, Arrowsmith, C.H, Berglund, H, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Moche, M, Nilsson, M.E, Nyman, T, Olesen, K, Persson, C, Sagemark, J, Schueler, H, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wisniewska, M, Wikstrom, M, Nordlund, P. | Deposit date: | 2008-07-08 | Release date: | 2008-08-12 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Substrate Specificity and Oligomerization of Human Gmp Synthetase J.Mol.Biol., 425, 2013
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4Z4P
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![BU of 4z4p by Molmil](/molmil-images/mine/4z4p) | Structure of the MLL4 SET Domain | Descriptor: | Histone-lysine N-methyltransferase 2D, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | Authors: | Zhang, Z, Mittal, A, Reid, J, Reich, S, Gamblin, S.J, Wilson, J.R. | Deposit date: | 2015-04-02 | Release date: | 2015-09-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Evolving Catalytic Properties of the MLL Family SET Domain. Structure, 23, 2015
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5GT5
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6JPQ
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![BU of 6jpq by Molmil](/molmil-images/mine/6jpq) | CryoEM structure of Abo1 hexamer - ADP complex | Descriptor: | Uncharacterized AAA domain-containing protein C31G5.19 | Authors: | Cho, C, Jang, J, Song, J.J. | Deposit date: | 2019-03-27 | Release date: | 2020-08-19 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.44 Å) | Cite: | Structural basis of nucleosome assembly by the Abo1 AAA+ ATPase histone chaperone. Nat Commun, 10, 2019
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6GIQ
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![BU of 6giq by Molmil](/molmil-images/mine/6giq) | Saccharomyces cerevisiae respiratory supercomplex III2IV | Descriptor: | (1R)-2-(dodecanoyloxy)-1-[(phosphonooxy)methyl]ethyl tetradecanoate, (1R)-2-(phosphonooxy)-1-[(tridecanoyloxy)methyl]ethyl pentadecanoate, (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate, ... | Authors: | Rathore, S, Berndtsson, J, Conrad, J, Ott, M. | Deposit date: | 2018-05-15 | Release date: | 2019-01-02 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Cryo-EM structure of the yeast respiratory supercomplex. Nat. Struct. Mol. Biol., 26, 2019
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4B05
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![BU of 4b05 by Molmil](/molmil-images/mine/4b05) | Preclinical characterization of AZD3839, a novel clinical candidate BACE1 inhibitor for the treatment of Alzheimer Disease | Descriptor: | (1S)-1-[2-(difluoromethyl)pyridin-4-yl]-4-fluoro-1-(3-pyrimidin-5-ylphenyl)-1H-isoindol-3-amine, ACETATE ION, BETA-SECRETASE 1, ... | Authors: | Jeppsson, F, Eketjall, S, Janson, J, Karlstrom, S, Gustavsson, S, Olsson, L.L, Radesater, A.C, Ploeger, B, Cebers, G, Kolmodin, K, Swahn, B.M, von Berg, S, Bueters, T, Falting, J. | Deposit date: | 2012-06-28 | Release date: | 2012-10-17 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease. J. Biol. Chem., 287, 2012
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6H2D
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6GRK
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6H2E
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4A2Z
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![BU of 4a2z by Molmil](/molmil-images/mine/4a2z) | CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND | Descriptor: | 4-METHOXY-2,3,6-TRIMETHYL-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE, CHLORIDE ION, GLYCEROL, ... | Authors: | Robinson, D.A, Brand, S, Fairlamb, A.H, Ferguson, M.A.J, Frearson, J.A, Wyatt, P.G. | Deposit date: | 2011-09-29 | Release date: | 2011-12-21 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors. J. Med. Chem., 55, 2012
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7CRN
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6JPU
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![BU of 6jpu by Molmil](/molmil-images/mine/6jpu) | CryoEM structure of Abo1 hexamer - apo complex | Descriptor: | Uncharacterized AAA domain-containing protein C31G5.19 | Authors: | Cho, C, Jang, J, Song, J.J. | Deposit date: | 2019-03-28 | Release date: | 2019-12-25 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.27 Å) | Cite: | Structural basis of nucleosome assembly by the Abo1 AAA+ ATPase histone chaperone. Nat Commun, 10, 2019
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6A6K
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![BU of 6a6k by Molmil](/molmil-images/mine/6a6k) | Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000 | Descriptor: | 3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol, Estrogen-related receptor gamma | Authors: | Yoon, H, Kim, J, Chin, J, Cho, S.J, Song, J. | Deposit date: | 2018-06-28 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-gamma Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer. J. Med. Chem., 62, 2019
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7SI5
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![BU of 7si5 by Molmil](/molmil-images/mine/7si5) | CRYSTAL STRUCTURE OF EED WITH MRTX-1919 | Descriptor: | (4R)-8-(1,3-dimethyl-1H-pyrazol-5-yl)-5-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}imidazo[1,2-c]pyrimidine-2-carbonitrile, 1,2-ETHANEDIOL, FORMIC ACID, ... | Authors: | Gunn, R.J, Burns, A.C, Lawson, J.D, Marx, M.A. | Deposit date: | 2021-10-12 | Release date: | 2022-11-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | CRYSTAL STRUCTURE OF EED WITH MRTX-1919 TO BE PUBLISHED
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7SQ2
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![BU of 7sq2 by Molmil](/molmil-images/mine/7sq2) | Reprocessed and refined structure of Phospholipase C-beta and Gq signaling complex | Descriptor: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, ACETATE ION, CALCIUM ION, ... | Authors: | Endo-Streeter, S.T, Sondek, J, Harden, T.K. | Deposit date: | 2021-11-04 | Release date: | 2021-11-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Kinetic Scaffolding Mediated by a Phospholipase C-{beta} and Gq Signaling Complex Science, 330, 2010
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6P3W
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6PGW
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8DT0
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6UD6
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![BU of 6ud6 by Molmil](/molmil-images/mine/6ud6) | Spectroscopic and structural characterization of a genetically encoded direct sensor for protein-ligand interactions | Descriptor: | CHLORIDE ION, GLYCEROL, Streptavidin | Authors: | Mills, J.H, Gleason, P.R, Simmons, C.R, Henderson, J.N, Kartchner, B.K. | Deposit date: | 2019-09-18 | Release date: | 2020-09-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.502 Å) | Cite: | Structural Origins of Altered Spectroscopic Properties upon Ligand Binding in Proteins Containing a Fluorescent Noncanonical Amino Acid. Biochemistry, 60, 2021
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6UDC
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![BU of 6udc by Molmil](/molmil-images/mine/6udc) | Spectroscopic and structural characterization of a genetically encoded direct sensor for protein-ligand interactions | Descriptor: | BIOTIN, Streptavidin | Authors: | Mills, J.H, Gleason, P.R, Simmons, C.R, Henderson, J.N, Kartchner, B.K. | Deposit date: | 2019-09-19 | Release date: | 2020-09-23 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Origins of Altered Spectroscopic Properties upon Ligand Binding in Proteins Containing a Fluorescent Noncanonical Amino Acid. Biochemistry, 60, 2021
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6GIK
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![BU of 6gik by Molmil](/molmil-images/mine/6gik) | NMR structure of temporin B L1FK in SDS micelles | Descriptor: | temporinB_L1FK | Authors: | Manzo, G, Mason, J.A. | Deposit date: | 2018-05-12 | Release date: | 2018-06-13 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity. Sci Rep, 9, 2019
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