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4A2Z

CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND

Summary for 4A2Z
Entry DOI10.2210/pdb4a2z/pdb
Related2WSA 4A30 4A31 4A32 4A33
DescriptorGLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, GLYCEROL, 4-METHOXY-2,3,6-TRIMETHYL-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE, ... (6 entities in total)
Functional Keywordsacyltransferase, transferase, drug discovery
Biological sourceLEISHMANIA MAJOR
Total number of polymer chains1
Total formula weight51956.13
Authors
Robinson, D.A.,Brand, S.,Fairlamb, A.H.,Ferguson, M.A.J.,Frearson, J.A.,Wyatt, P.G. (deposition date: 2011-09-29, release date: 2011-12-21, Last modification date: 2023-12-20)
Primary citationBrand, S.,Cleghorn, L.A.,McElroy, S.P.,Robinson, D.A.,Smith, V.C.,Hallyburton, I.,Harrison, J.R.,Norcross, N.R.,Spinks, D.,Bayliss, T.,Norval, S.,Stojanovski, L.,Torrie, L.S.,Frearson, J.A.,Brenk, R.,Fairlamb, A.H.,Ferguson, M.A.,Read, K.D.,Wyatt, P.G.,Gilbert, I.H.
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
J. Med. Chem., 55:140-152, 2012
Cited by
PubMed: 22148754
DOI: 10.1021/jm201091t
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.31 Å)
Structure validation

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