4A2Z

CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE	polymer	438	50513.3	1	UniProt (Q4Q5S8) Pfam (PF01233) Pfam (PF02799) In PDB	LEISHMANIA MAJOR	N-MYRISTOYL TRANSFERASE
2	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
3	A	4-METHOXY-2,3,6-TRIMETHYL-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE	non-polymer		337.4	1	Chemie (VIQ)
4	A	TETRADECANOYL-COA	non-polymer		977.9	1	Chemie (MYA)
5	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6		water	water		18.0	204	Chemie (HOH)

Sequence modifications

A: 5 - 421 (UniProt: Q4Q5S8)

PDB	External Database	Details
Met -16	-	expression tag
Gly -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Ser -6	-	expression tag
Ser -5	-	expression tag
Gly -4	-	expression tag
Arg -3	-	expression tag
Glu -2	-	expression tag
Asn -1	-	expression tag
Leu 0	-	expression tag
Tyr 1	-	expression tag
Phe 2	-	expression tag
Gln 3	-	expression tag
Gly 4	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	50513.3
Non-Polymers*	Number of molecules	4
	Total formula weight	1442.9
All*	Total formula weight	51956.1

*Water molecules are not included.