4A31
CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND
Summary for 4A31
Entry DOI | 10.2210/pdb4a31/pdb |
Related | 2WSA 4A2Z 4A30 4A32 4A33 |
Descriptor | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, GLYCEROL, 6-{[2-(4-METHYLPIPERAZIN-1-YL)ETHYL]AMINO}-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)PYRIDINE-3-SULFONAMIDE, ... (5 entities in total) |
Functional Keywords | acyltransferase, transferase, drug discovery, leishmaniasis |
Biological source | LEISHMANIA MAJOR |
Total number of polymer chains | 1 |
Total formula weight | 51990.77 |
Authors | Robinson, D.A.,Brand, S.,Cleghorn, L.A.T.,McElroy, S.P.,Smith, V.C.,Hallyburton, I.,Harrison, J.R.,Norcross, N.R.,Norval, S.,Spinks, D.,Stojanovski, L.,Torrie, L.S.,Frearson, J.A.,Brenk, R.,Fairlamb, A.H.,Ferguson, M.A.J.,Read, K.D.,Wyatt, P.G.,Gilbert, I.H. (deposition date: 2011-09-29, release date: 2011-12-21, Last modification date: 2023-12-20) |
Primary citation | Brand, S.,Cleghorn, L.A.,McElroy, S.P.,Robinson, D.A.,Smith, V.C.,Hallyburton, I.,Harrison, J.R.,Norcross, N.R.,Spinks, D.,Bayliss, T.,Norval, S.,Stojanovski, L.,Torrie, L.S.,Frearson, J.A.,Brenk, R.,Fairlamb, A.H.,Ferguson, M.A.,Read, K.D.,Wyatt, P.G.,Gilbert, I.H. Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors. J. Med. Chem., 55:140-152, 2012 Cited by PubMed: 22148754DOI: 10.1021/jm201091t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
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