4A31
CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE | polymer | 438 | 50513.3 | 1 | UniProt (Q4Q5S8) Pfam (PF01233) Pfam (PF02799) In PDB | LEISHMANIA MAJOR | N-MYRISTOYL TRANSFERASE |
2 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
3 | A | 6-{[2-(4-METHYLPIPERAZIN-1-YL)ETHYL]AMINO}-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)PYRIDINE-3-SULFONAMIDE | non-polymer | 407.5 | 1 | Chemie (2CB) | |||
4 | A | TETRADECANOYL-COA | non-polymer | 977.9 | 1 | Chemie (MYA) | |||
5 | water | water | 18.0 | 306 | Chemie (HOH) |
Sequence modifications
A: 5 - 421 (UniProt: Q4Q5S8)
PDB | External Database | Details |
---|---|---|
Met -16 | - | expression tag |
Gly -15 | - | expression tag |
Ser -14 | - | expression tag |
Ser -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
Ser -6 | - | expression tag |
Ser -5 | - | expression tag |
Gly -4 | - | expression tag |
Arg -3 | - | expression tag |
Glu -2 | - | expression tag |
Asn -1 | - | expression tag |
Leu 0 | - | expression tag |
Tyr 1 | - | expression tag |
Phe 2 | - | expression tag |
Gln 3 | - | expression tag |
Gly 4 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 50513.3 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1477.5 | |
All* | Total formula weight | 51990.8 |