6N1R
 
 | | Tetrahedral oligomeric complex of GyrA N-terminal fragment, solved by cryoEM in tetrahedral symmetry | | 分子名称: | DNA gyrase subunit A | | 著者 | Soczek, K.M, Grant, T, Rosenthal, P.B, Mondragon, A. | | 登録日 | 2018-11-10 | | 公開日 | 2018-12-05 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | CryoEM structures of open dimers of Gyrase A in complex with DNA illuminate mechanism of strand passage.
Elife, 7, 2018
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6N1P
 | | Dihedral oligomeric complex of GyrA N-terminal fragment with DNA, solved by cryoEM in C2 symmetry | | 分子名称: | DNA (44-MER), DNA gyrase subunit A | | 著者 | Soczek, K.M, Grant, T, Rosenthal, P.B, Mondragon, A. | | 登録日 | 2018-11-10 | | 公開日 | 2018-12-05 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (6.35 Å) | | 主引用文献 | CryoEM structures of open dimers of Gyrase A in complex with DNA illuminate mechanism of strand passage.
Elife, 7, 2018
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6N1Q
 | | Dihedral oligomeric complex of GyrA N-terminal fragment, solved by cryoEM in D2 symmetry | | 分子名称: | DNA gyrase subunit A | | 著者 | Soczek, K.M, Grant, T, Rosenthal, P.B, Mondragon, A. | | 登録日 | 2018-11-10 | | 公開日 | 2018-12-05 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (5.16 Å) | | 主引用文献 | CryoEM structures of open dimers of Gyrase A in complex with DNA illuminate mechanism of strand passage.
Elife, 7, 2018
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8UZB
 | | Cryo-EM structure of iGeoCas9 in complex with sgRNA and target DNA | | 分子名称: | CRISPR-associated endonuclease Cas9, Non-target strand DNA, RNA (107-MER), ... | | 著者 | Eggers, A.R, Soczek, K.M, Tuck, O.T, Doudna, J.A. | | 登録日 | 2023-11-14 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | | 主引用文献 | Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9.
Cell, 187, 2024
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8UZA
 | | Cryo-EM structure of GeoCas9 in complex with sgRNA and target DNA | | 分子名称: | CRISPR-associated endonuclease Cas9, Non-target strand DNA, Target strand DNA, ... | | 著者 | Eggers, A.R, Soczek, K.M, Tuck, O.T, Doudna, J.A. | | 登録日 | 2023-11-14 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | | 主引用文献 | Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9.
Cell, 187, 2024
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7S37
 | | Cas9:sgRNA (S. pyogenes) in the open-protein conformation | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, Single-guide RNA | | 著者 | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | | 登録日 | 2021-09-04 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
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7S38
 | | Cas9:sgRNA:DNA (S. pyogenes) forming a 3-base-pair R-loop | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ... | | 著者 | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | | 登録日 | 2021-09-04 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-05-04 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
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7S3H
 | | Cas9:sgRNA:DNA (S. pyogenes) with 0 RNA:DNA base pairs, open-protein/linear-DNA conformation | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ... | | 著者 | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | | 登録日 | 2021-09-06 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-05-04 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
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7S36
 | | Cas9:sgRNA:DNA (S. pyogenes) with 0 RNA:DNA base pairs, closed-protein/bent-DNA conformation | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ... | | 著者 | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | | 登録日 | 2021-09-04 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-05-04 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
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8FYA
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-containing prespacer complex | | 分子名称: | Cas1, Cas2-DEDDh, DNA (28-MER), ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYB
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex | | 分子名称: | Cas1, Cas2-DEDDh, DNA (17-MER), ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYC
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex linear CRISPR repeat conformation | | 分子名称: | Cas1, Cas2-DEDDh, DEDDh, ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FY9
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-deficient prespacer complex | | 分子名称: | Cas1, Cas2-DEDDh, DNA (28-MER) | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYD
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex bent CRISPR repeat conformation | | 分子名称: | Cas1, Cas2-DEDDh, DNA (13-MER), ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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