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PDB: 158 results

6BX3
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BU of 6bx3 by Molmil
Structure of histone H3k4 methyltransferase
Descriptor: COMPASS component BRE2, COMPASS component SDC1, COMPASS component SPP1, ...
Authors:Skiniotis, G, Qu, Q.H.
Deposit date:2017-12-16
Release date:2018-09-05
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.
Cell, 174, 2018
6WHA
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BU of 6wha by Molmil
HTR2A bound to 25-CN-NBOH in complex with a mini-Galpha-q protein, beta/gamma subunits and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)
Descriptor: 4-(2-{[(2-hydroxyphenyl)methyl]amino}ethyl)-2,5-dimethoxybenzonitrile, G subunit q (Gi2-mini-Gq chimeric), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Skiniotis, G, Roth, B, Kim, K, Panova, O.
Deposit date:2020-04-07
Release date:2020-09-23
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor
Cell(Cambridge,Mass.), 182, 2020
3JCS
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BU of 3jcs by Molmil
2.8 Angstrom cryo-EM structure of the large ribosomal subunit from the eukaryotic parasite Leishmania
Descriptor: 26S alpha ribosomal RNA, 26S delta ribosomal RNA, 26S epsilon ribosomal RNA, ...
Authors:Shalev-Benami, M, Zhang, Y, Matzov, D, Halfon, Y, Zackay, A, Rozenberg, H, Zimmerman, E, Bashan, A, Jaffe, C.L, Yonath, A, Skiniotis, G.
Deposit date:2016-01-21
Release date:2016-07-20
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:2.8- angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.
Cell Rep, 16, 2016
3SN6
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BU of 3sn6 by Molmil
Crystal structure of the beta2 adrenergic receptor-Gs protein complex
Descriptor: 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid antibody VHH fragment, Endolysin,Beta-2 adrenergic receptor, ...
Authors:Rasmussen, S.G.F, DeVree, B.T, Zou, Y, Kruse, A.C, Chung, K.Y, Kobilka, T.S, Thian, F.S, Chae, P.S, Pardon, E, Calinski, D, Mathiesen, J.M, Shah, S.T.A, Lyons, J.A, Caffrey, M, Gellman, S.H, Steyaert, J, Skiniotis, G, Weis, W.I, Sunahara, R.K, Kobilka, B.K.
Deposit date:2011-06-28
Release date:2011-07-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the beta2 adrenergic receptor-Gs protein complex
Nature, 477, 2011
8EL8
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BU of 8el8 by Molmil
CryoEM structure of Resistance to Inhibitors of Cholinesterase-8B (Ric-8B) in complex with olfactory G protein alpha olf
Descriptor: Guanine nucleotide-binding protein G(olf) subunit alpha, Isoform 1 of Synembryn-B
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2022-09-23
Release date:2023-03-01
Last modified:2023-05-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures of Ric-8B in complex with G alpha protein folding clients reveal isoform specificity mechanisms.
Structure, 31, 2023
8EL7
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BU of 8el7 by Molmil
CryoEM structure of Resistance to Inhibitors of Cholinesterase-8B (Ric-8B) in complex with G alpha s
Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Isoform 1 of Synembryn-B
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2022-09-23
Release date:2023-03-01
Last modified:2023-05-17
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structures of Ric-8B in complex with G alpha protein folding clients reveal isoform specificity mechanisms.
Structure, 31, 2023
7JSN
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BU of 7jsn by Molmil
Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6
Descriptor: 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE, GUANOSINE-3',5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Gao, Y, Eskici, G, Ramachandran, S, Skiniotis, G, Cerione, R.A.
Deposit date:2020-08-15
Release date:2020-10-21
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.
Mol.Cell, 80, 2020
7JHJ
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BU of 7jhj by Molmil
Structure of the Epstein-Barr virus GPCR BILF1 in complex with human Gi
Descriptor: Antibody fragment scFv16, BILF1, CHOLESTEROL HEMISUCCINATE, ...
Authors:Tsutsumi, N, Qu, Q.H, Skiniotis, G, Garcia, K.C.
Deposit date:2020-07-20
Release date:2021-07-07
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1.
Immunity, 54, 2021
7MTQ
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BU of 7mtq by Molmil
CryoEM Structure of Full-Length mGlu2 in Inactive-State Bound to Antagonist LY341495
Descriptor: 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 2
Authors:Seven, A.B, Barros-Alvarez, X, Skiniotis, G.
Deposit date:2021-05-13
Release date:2021-07-07
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:G-protein activation by a metabotropic glutamate receptor.
Nature, 595, 2021
7MTR
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BU of 7mtr by Molmil
CryoEM Structure of Full-Length mGlu2 Bound to Ago-PAM ADX55164 and Glutamate
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine, GLUTAMIC ACID, ...
Authors:Seven, A.B, Barros-Alvarez, X, Skiniotis, G.
Deposit date:2021-05-13
Release date:2021-07-07
Last modified:2021-09-08
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:G-protein activation by a metabotropic glutamate receptor.
Nature, 595, 2021
7MTS
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BU of 7mts by Molmil
CryoEM Structure of mGlu2 - Gi Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine, GLUTAMIC ACID, ...
Authors:Seven, A.B, Barros-Alvarez, X, Skiniotis, G.
Deposit date:2021-05-13
Release date:2021-07-07
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:G-protein activation by a metabotropic glutamate receptor.
Nature, 595, 2021
7M3G
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BU of 7m3g by Molmil
Asymmetric Activation of the Calcium Sensing Receptor Homodimer
Descriptor: 2-[4-[(3S)-3-[[(1R)-1-naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gao, Y, Robertson, M.J, Zhang, C, Meyerowitz, J.G, Panova, O, Skiniotis, G.
Deposit date:2021-03-18
Release date:2021-06-30
Last modified:2021-07-21
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Asymmetric activation of the calcium-sensing receptor homodimer.
Nature, 595, 2021
7M3E
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BU of 7m3e by Molmil
Asymmetric Activation of the Calcium Sensing Receptor Homodimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile, ...
Authors:Gao, Y, Robertson, M.J, Zhang, C, Meyerowitz, J.G, Panova, O, Skiniotis, G.
Deposit date:2021-03-18
Release date:2021-06-30
Last modified:2021-07-21
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Asymmetric activation of the calcium-sensing receptor homodimer.
Nature, 595, 2021
7M3J
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BU of 7m3j by Molmil
Asymmetric Activation of the Calcium Sensing Receptor Homodimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile, ...
Authors:Gao, Y, Robertson, M.J, Zhang, C, Meyerowitz, J.G, Panova, O, Skiniotis, G.
Deposit date:2021-03-18
Release date:2021-06-30
Last modified:2021-07-21
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Asymmetric activation of the calcium-sensing receptor homodimer.
Nature, 595, 2021
7M3F
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BU of 7m3f by Molmil
Asymmetric Activation of the Calcium Sensing Receptor Homodimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Gao, Y, Robertson, M.J, Zhang, C, Meyerowitz, J.G, Panova, O, Skiniotis, G.
Deposit date:2021-03-18
Release date:2021-06-30
Last modified:2021-07-21
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Asymmetric activation of the calcium-sensing receptor homodimer.
Nature, 595, 2021
2V5M
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BU of 2v5m by Molmil
Structural basis for Dscam isoform specificity
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DSCAM, GLYCEROL
Authors:Meijers, R, Puettmann-Holgado, R, Skiniotis, G, Liu, J.-H, Walz, T, Schmucker, D, Wang, J.-H.
Deposit date:2007-07-06
Release date:2007-09-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Basis of Dscam Isoform Specificity
Nature, 449, 2007
2V5S
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BU of 2v5s by Molmil
Structural basis for Dscam isoform specificity
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DSCAM
Authors:Meijers, R, Puettmann-Holgado, R, Skiniotis, G, Liu, J.-H, Walz, T, Schmucker, D, Wang, J.-H.
Deposit date:2007-07-09
Release date:2007-09-11
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis of Dscam Isoform Specificity
Nature, 449, 2007
2V5R
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BU of 2v5r by Molmil
Structural basis for Dscam isoform specificity
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, DSCAM, GLYCEROL
Authors:Meijers, R, Puettmann-Holgado, R, Skiniotis, G, Liu, J.-H, Walz, T, Schmucker, D, Wang, J.-H.
Deposit date:2007-07-09
Release date:2007-09-11
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis of Dscam Isoform Specificity
Nature, 449, 2007
6DDF
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BU of 6ddf by Molmil
Mu Opioid Receptor-Gi Protein Complex
Descriptor: DAMGO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Koehl, A, Hu, H, Maeda, S, Manglik, A, Kobilka, B.K, Skiniotis, G, Weis, W.I.
Deposit date:2018-05-10
Release date:2018-06-13
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the mu-opioid receptor-Giprotein complex.
Nature, 558, 2018
6DDE
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BU of 6dde by Molmil
Mu Opioid Receptor-Gi Protein Complex
Descriptor: DAMGO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Koehl, A, Hu, H, Maeda, S, Manglik, A, Zhang, Y, Kobilka, B.K, Skiniotis, G, Weis, W.I.
Deposit date:2018-05-10
Release date:2018-06-13
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the mu-opioid receptor-Giprotein complex.
Nature, 558, 2018
4X8N
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BU of 4x8n by Molmil
Crystal structure of Ash2L SPRY domain in complex with phosphorylated RbBP5
Descriptor: Retinoblastoma-binding protein 5, Set1/Ash2 histone methyltransferase complex subunit ASH2
Authors:Zhang, P, Chaturvedi, C.P, Brunzelle, J.S, Skiniotis, G, Brand, M, Shilatifard, A, Couture, J.-F.
Deposit date:2014-12-10
Release date:2015-01-28
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation.
Genes Dev., 29, 2015
4X8P
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BU of 4x8p by Molmil
Crystal structure of Ash2L SPRY domain in complex with RbBP5
Descriptor: GLYCEROL, Retinoblastoma-binding protein 5, Set1/Ash2 histone methyltransferase complex subunit ASH2,Set1/Ash2 histone methyltransferase complex subunit ASH2
Authors:Zhang, P, Chaturvedi, C.P, Brunzelle, J.S, Skiniotis, G, Brand, M, Shilatifard, A, Couture, J.-F.
Deposit date:2014-12-10
Release date:2015-01-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation.
Genes Dev., 29, 2015
6XEU
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BU of 6xeu by Molmil
CryoEM structure of GIRK2PIP2* - G protein-gated inwardly rectifying potassium channel GIRK2 with PIP2
Descriptor: G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, SODIUM ION, ...
Authors:Mathiharan, Y.K, Glaaser, I.W, Skiniotis, G, Slesinger, P.A.
Deposit date:2020-06-13
Release date:2021-09-01
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural insights into GIRK2 channel modulation by cholesterol and PIP2
Cell Rep, 36, 2021
6XEV
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BU of 6xev by Molmil
CryoEM structure of GIRK2-PIP2/CHS - G protein-gated inwardly rectifying potassium channel GIRK2 with modulators cholesteryl hemisuccinate and PIP2
Descriptor: CHOLESTEROL HEMISUCCINATE, G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, ...
Authors:Mathiharan, Y.K, Glaaser, I.W, Skiniotis, G, Slesinger, P.A.
Deposit date:2020-06-14
Release date:2021-09-01
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural insights into GIRK2 channel modulation by cholesterol and PIP2
Cell Rep, 36, 2021
7UL2
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BU of 7ul2 by Molmil
CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6
Descriptor: 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Nanobody 6, Neurotensin receptor 1, ...
Authors:Robertson, M.J, Skiniotis, G.
Deposit date:2022-04-03
Release date:2022-06-29
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structure determination of inactive-state GPCRs with a universal nanobody.
Nat.Struct.Mol.Biol., 29, 2022

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