4X8P

Crystal structure of Ash2L SPRY domain in complex with RbBP5

Summary for 4X8P

• Entry DOI: 10.2210/pdb4x8p/pdb
• Related: 4X8N
• Descriptor: Set1/Ash2 histone methyltransferase complex subunit ASH2,Set1/Ash2 histone methyltransferase complex subunit ASH2, Retinoblastoma-binding protein 5, GLYCEROL, ... (4 entities in total)
• Functional Keywords: histone, mll1, epigenetics, protein binding
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q9UBL3 Q15291
• Total number of polymer chains: 2
• Total formula weight: 22076.83

Authors

Zhang, P.,Chaturvedi, C.P.,Brunzelle, J.S.,Skiniotis, G.,Brand, M.,Shilatifard, A.,Couture, J.-F. (deposition date: 2014-12-10, release date: 2015-01-28, Last modification date: 2024-02-28)

• Primary citation: Zhang, P.,Chaturvedi, C.P.,Tremblay, V.,Cramet, M.,Brunzelle, J.S.,Skiniotis, G.,Brand, M.,Shilatifard, A.,Couture, J.F.; A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation.; Genes Dev., 29:123-128, 2015; PubMed: 25593305; DOI: 10.1101/gad.254870.114

Experimental method

X-RAY DIFFRACTION (2.2 Å)