6XEV
CryoEM structure of GIRK2-PIP2/CHS - G protein-gated inwardly rectifying potassium channel GIRK2 with modulators cholesteryl hemisuccinate and PIP2
Summary for 6XEV
Entry DOI | 10.2210/pdb6xev/pdb |
EMDB information | 22150 22151 22152 22153 22154 22155 |
Descriptor | G protein-activated inward rectifier potassium channel 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, CHOLESTEROL HEMISUCCINATE, ... (5 entities in total) |
Functional Keywords | cryoem, girk, inwardly rectifying potassium channel, cholesterol, lipids, pip2, transport protein |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 4 |
Total formula weight | 161781.23 |
Authors | Mathiharan, Y.K.,Glaaser, I.W.,Skiniotis, G.,Slesinger, P.A. (deposition date: 2020-06-14, release date: 2021-09-01) |
Primary citation | Mathiharan, Y.K.,Glaaser, I.W.,Zhao, Y.,Robertson, M.J.,Skiniotis, G.,Slesinger, P.A. Structural insights into GIRK2 channel modulation by cholesterol and PIP2 Cell Rep, 36:109619-, 2021 Cited by DOI: 10.1016/j.celrep.2021.109619PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
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