6XEV
CryoEM structure of GIRK2-PIP2/CHS - G protein-gated inwardly rectifying potassium channel GIRK2 with modulators cholesteryl hemisuccinate and PIP2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, E, I, M) | G protein-activated inward rectifier potassium channel 2 | polymer | 340 | 39062.0 | 4 | UniProt (A0A338P6L0) Pfam (PF01007) Pfam (PF17655) UniProt (by SIFTS) (P48542) | Mus musculus (Mouse) | |
| 2 | AA, E, S, W (M, A, E, I) | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 4 | Chemie (PIO) | |||
| 3 | BA, F, T, X (M, A, E, I) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) | |||
| 4 | G, H, I, J, K... (A, I, M) | POTASSIUM ION | non-polymer | 39.1 | 13 | Chemie (K) | |||
| 5 | CA, R, U, Y (M, A, E, I) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) |
Sequence modifications
A, E, I, M: 52 - 380 (UniProt: A0A338P6L0)
| PDB | External Database | Details |
|---|---|---|
| Met 50 | - | expression tag |
| Ala 51 | - | expression tag |
| Ser 381 | - | expression tag |
| Asn 382 | - | expression tag |
| Ser 383 | - | expression tag |
| Leu 384 | - | expression tag |
| Glu 385 | - | expression tag |
| Val 386 | - | expression tag |
| Leu 387 | - | expression tag |
| Phe 388 | - | expression tag |
| Gln 389 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 156247.8 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 5533.4 | |
| All* | Total formula weight | 161781.2 |
