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PDB: 25 件
6WOX
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BU of 6wox by Molmil
Thermus thermophilus RNA polymerase initially transcribing complex with 2'dCTP
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*G)-3'), ...
著者Shin, Y, Murakami, K.S.
登録日2020-04-26
公開日2020-06-10
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.14 Å)
主引用文献The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases.
Nat Commun, 12, 2021
6WOY
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BU of 6woy by Molmil
Thermus thermophilus RNA polymerase initially transcribing complex with 3'dCTP
分子名称: 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*G)-3'), ...
著者Shin, Y, Murakami, K.S.
登録日2020-04-26
公開日2020-06-10
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases.
Nat Commun, 12, 2021
6OY5
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BU of 6oy5 by Molmil
X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter at 3 min
分子名称: DNA (5'-D(*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*CP*TP*CP*TP*GP*AP*TP*GP*CP*AP*G)-3'), DNA (5'-D(P*CP*CP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*AP*T)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Shin, Y, Murakami, K.S.
登録日2019-05-14
公開日2019-06-05
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase.
Nucleic Acids Res., 48, 2020
6OVR
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BU of 6ovr by Molmil
X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter variant -1G
分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*CP*TP*GP*AP*TP*GP*CP*AP*GP*G)-3'), DNA (5'-D(P*GP*GP*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*GP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Shin, Y, Murakami, K.S.
登録日2019-05-08
公開日2019-07-24
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.843 Å)
主引用文献Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase.
Nucleic Acids Res., 48, 2020
6OW3
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BU of 6ow3 by Molmil
X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter variant -1T
分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*GP*AP*TP*CP*TP*GP*AP*TP*GP*C)-3'), DNA (5'-D(P*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*TP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Shin, Y, Murakami, K.S.
登録日2019-05-09
公開日2019-07-24
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.766 Å)
主引用文献Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase.
Nucleic Acids Res., 48, 2020
6OY6
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BU of 6oy6 by Molmil
X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter at 5 min
分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*GP*AP*TP*CP*TP*GP*AP*TP*GP*CP*AP*GP*G)-3'), DNA (5'-D(P*CP*CP*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Shin, Y, Murakami, K.S.
登録日2019-05-14
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.096 Å)
主引用文献Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase.
Nucleic Acids Res., 48, 2020
6P70
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BU of 6p70 by Molmil
X-ray crystal structure of bacterial RNA polymerase and pyrBI promoter complex
分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*CP*GP*AP*TP*CP*TP*TP*TP*GP*CP*CP*GP*GP*G)-3'), DNA (5'-D(P*TP*CP*CP*CP*GP*GP*CP*AP*AP*AP*TP*TP*GP*TP*CP*CP*G)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Shin, Y, Murakami, K.S.
登録日2019-06-04
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.052 Å)
主引用文献Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase.
Nucleic Acids Res., 48, 2020
6P71
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BU of 6p71 by Molmil
X-ray crystal structure of a bacterial reiterative transcription complex of pyrBI promoter
分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*CP*GP*AP*GP*CP*CP*GP*GP*GP*A)-3'), DNA (5'-D(P*CP*TP*CP*CP*CP*GP*GP*CP*AP*AP*AP*TP*TP*GP*T)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Shin, Y, Murakami, K.S.
登録日2019-06-04
公開日2019-07-24
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase.
Nucleic Acids Res., 48, 2020
7R8J
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BU of 7r8j by Molmil
Crystal structure of Pseudooceanicola lipolyticus Argonaute bound to 5' p guide DNA in the presence of Mg2+
分子名称: Argonaute, DNA (5'-D(*TP*TP*AP*CP*TP*GP*CP*AP*CP*AP*GP*GP*TP*GP*AP*CP*GP*A)-3')
著者Shin, Y, Murakami, K.S.
登録日2021-06-26
公開日2022-07-06
最終更新日2022-12-28
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity.
Nat Commun, 13, 2022
7R8F
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BU of 7r8f by Molmil
Crystal structure of Pseudooceanicola lipolyticus Argonaute
分子名称: Argonaute
著者Shin, Y, Murakami, K.S.
登録日2021-06-26
公開日2022-07-06
最終更新日2022-12-28
実験手法X-RAY DIFFRACTION (3.16 Å)
主引用文献Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity.
Nat Commun, 13, 2022
7R8G
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BU of 7r8g by Molmil
Crystal structure of Pseudooceanicola lipolyticus Argonaute bound to 5' OH guide DNA
分子名称: Argonaute, DNA (5'-D(*TP*AP*CP*TP*GP*CP*AP*CP*AP*GP*GP*TP*GP*AP*CP*GP*A)-3')
著者Shin, Y, Murakami, K.S.
登録日2021-06-26
公開日2022-07-06
最終更新日2022-12-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity.
Nat Commun, 13, 2022
7R8H
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BU of 7r8h by Molmil
Crystal structure of Pseudooceanicola lipolyticus Argonaute bound to 5' p guide DNA
分子名称: Argonaute, DNA (5'-D(*TP*TP*AP*CP*TP*GP*CP*AP*CP*AP*GP*GP*TP*GP*AP*CP*GP*A)-3')
著者Shin, Y, Murakami, K.S.
登録日2021-06-26
公開日2022-07-06
最終更新日2022-12-28
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity.
Nat Commun, 13, 2022
7R8K
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BU of 7r8k by Molmil
Crystal structure of Pseudooceanicola lipolyticus Argonaute (SeMet labeled protein)
分子名称: Argonaute
著者Shin, Y, Murakami, K.S.
登録日2021-06-26
公開日2022-07-06
最終更新日2022-12-28
実験手法X-RAY DIFFRACTION (3.28 Å)
主引用文献Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity.
Nat Commun, 13, 2022
7R8I
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BU of 7r8i by Molmil
Crystal structure of Pseudooceanicola lipolyticus Argonaute bound to 5' OH guide DNA in the presence of Mg2+
分子名称: Argonaute, DNA (5'-D(*TP*TP*AP*CP*TP*GP*CP*AP*CP*AP*GP*GP*TP*GP*AP*CP*GP*A), MAGNESIUM ION
著者Shin, Y, Murakami, K.S.
登録日2021-06-26
公開日2022-11-09
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of Pseudooceanicola lipolyticus Argonaute bound to 5' OH guide DNA in the presence of Mg2+
To be published
7SZK
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BU of 7szk by Molmil
Cryo-EM structure of 27a bound to E. coli RNAP and rrnBP1 promoter complex
分子名称: (2S,7R,7aR,13aP,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,21,23-trihydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-12-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1,6,15-trioxo-1,2,7,7a-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate, DNA (5'-D(P*CP*TP*CP*GP*TP*AP*GP*AP*GP*TP*CP*CP*GP*TP*GP*TP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Shin, Y, Murakami, K.S.
登録日2021-11-28
公開日2022-07-13
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis.
Acs Infect Dis., 8, 2022
7SZJ
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BU of 7szj by Molmil
Cryo-EM structure of Rifamycin bound to E. coli RNAP and rrnBP1 promoter complex
分子名称: DNA (49-MER), DNA (57-MER), DNA-directed RNA polymerase subunit alpha, ...
著者Shin, Y, Murakami, K.S.
登録日2021-11-28
公開日2022-07-13
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (3.11 Å)
主引用文献Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis.
Acs Infect Dis., 8, 2022
6OY7
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BU of 6oy7 by Molmil
X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter at 7 min
分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*TP*CP*TP*GP*AP*TP*GP*CP*AP*GP*G)-3'), DNA (5'-D(P*CP*CP*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Shin, Y, Murakami, K.S.
登録日2019-05-14
公開日2019-07-24
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.04 Å)
主引用文献Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase.
Nucleic Acids Res., 48, 2020
6OVY
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BU of 6ovy by Molmil
X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter variant -1C
分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*TP*CP*TP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*CP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Shin, Y, Murakami, K.S.
登録日2019-05-08
公開日2019-07-24
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.999 Å)
主引用文献Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase.
Nucleic Acids Res., 48, 2020
7KHE
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BU of 7khe by Molmil
Escherichia coli RNA polymerase and rrnBP1 promoter pre-open complex with DksA/ppGpp
分子名称: CHAPSO, DNA (46-MER), DNA (54-MER), ...
著者Shin, Y, Qayyum, M.Z, Murakami, K.S.
登録日2020-10-21
公開日2020-12-09
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.58 Å)
主引用文献Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
7KHB
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BU of 7khb by Molmil
Escherichia coli RNA polymerase and rrnBP1 promoter open complex
分子名称: CHAPSO, DNA (60-MER), DNA (64-MER), ...
著者Shin, Y, Qayyum, M.Z, Murakami, K.S.
登録日2020-10-20
公開日2020-10-28
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.53 Å)
主引用文献Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
7KHC
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BU of 7khc by Molmil
Escherichia coli RNA polymerase and rrnBP1 promoter closed complex
分子名称: CHAPSO, DNA (18 MER), DNA (63-MER), ...
著者Shin, Y, Qayyum, M.Z, Murakami, K.S.
登録日2020-10-20
公開日2020-10-28
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.14 Å)
主引用文献Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
7KHI
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BU of 7khi by Molmil
Escherichia coli RNA polymerase and rrnBP1 promoter complex with DksA/ppGpp
分子名称: CHAPSO, DNA (28-MER), DNA (36-MER), ...
著者Shin, Y, Qayyum, M.Z, Murakami, K.S.
登録日2020-10-21
公開日2020-10-28
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.62 Å)
主引用文献Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
4GVJ
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BU of 4gvj by Molmil
Tyk2 (JH1) in complex with adenosine di-phosphate
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Non-receptor tyrosine-protein kinase TYK2
著者Liang, J, Abbema, A.V, Bao, L, Barrett, K, Beresini, M, Berezhkovskiy, L, Blair, W, Chang, C, Driscoll, J, Eigenbrot, C, Ghilardi, N, Gibbons, P, Halladay, J, Johnson, A, Kohli, P.B, Lai, Y, Liimatta, M, Mantik, P, Menghrajani, K, Murray, J, Sambrone, A, Shao, Y, Shia, S, Shin, Y, Smith, J, Sohn, S, Stanley, M, Tsui, V, Ultsch, M, Wu, L, Zhang, B, Magnuson, S.
登録日2012-08-30
公開日2013-08-14
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Lead identification of novel and selective TYK2 inhibitors.
Eur.J.Med.Chem., 67, 2013
5VO8
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BU of 5vo8 by Molmil
X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter
分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*CP*TP*GP*AP*TP*GP*CP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Murakami, K.S, Shin, Y, Turnbough Jr, C.L, Molodtsov, V.
登録日2017-05-02
公開日2017-05-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5VOI
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BU of 5voi by Molmil
X-ray crystal structure of bacterial RNA polymerase and pyrG promoter complex
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Murakami, K.S, Shin, Y, Turnbough Jr, C.L, Molodtsov, V.
登録日2017-05-02
公開日2017-05-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017

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件を2024-05-15に公開中

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