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PDB: 165 results

6LB2
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BU of 6lb2 by Molmil
Crystal structure of rhesus macaque MHC class I molecule Mamu-B*098 complexed with mono-acyl glycerol
Descriptor: (2R)-2,3-dihydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, Beta-2-microglobulin, ...
Authors:Shima, Y, Morita, D.
Deposit date:2019-11-13
Release date:2020-04-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.69380951 Å)
Cite:Crystal structures of lysophospholipid-bound MHC class I molecules.
J.Biol.Chem., 295, 2020
6LAH
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BU of 6lah by Molmil
Crystal structure of rhesus macaque MHC class I molecule Mamu-B*098 complexed with lysophosphatidylcholine
Descriptor: (2R)-2,3-dihydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, Beta-2-microglobulin, ...
Authors:Shima, Y, Morita, D.
Deposit date:2019-11-12
Release date:2020-04-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Crystal structures of lysophospholipid-bound MHC class I molecules.
J.Biol.Chem., 295, 2020
6LAM
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BU of 6lam by Molmil
Crystal structure of rhesus macaque MHC class I molecule Mamu-B*098 complexed with lysophosphatidylethanolamine
Descriptor: (2R)-2,3-dihydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Shima, Y, Morita, D.
Deposit date:2019-11-12
Release date:2020-04-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of lysophospholipid-bound MHC class I molecules.
J.Biol.Chem., 295, 2020
6LT6
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BU of 6lt6 by Molmil
Crystal structure of rhesus macaque MHC class I molecule Mamu-B*05104 complexed with lysophosphatidylcholine
Descriptor: (2R)-2,3-dihydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, Beta-2-microglobulin, ...
Authors:Shima, Y, Morita, D.
Deposit date:2020-01-21
Release date:2020-04-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structures of lysophospholipid-bound MHC class I molecules.
J.Biol.Chem., 295, 2020
8ITG
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BU of 8itg by Molmil
Crystal structure of lasso peptide epimerase MslH in complexed with precursor peptide variant MslAW21G
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Poly-gamma-glutamate synthesis protein (Capsule biosynthesis protein), ...
Authors:Nakashima, Y, Hiroyuki, M.
Deposit date:2023-03-22
Release date:2023-06-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism.
Nat Commun, 14, 2023
8II0
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BU of 8ii0 by Molmil
FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(3-(3-chlorophenyl)isoxazol-5-yl)-3-hydroxypicolinoyl)glycine
Descriptor: 2-[[5-[3-(3-chlorophenyl)-1,2-oxazol-5-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ...
Authors:Nakashima, Y, Corner, T, Zhang, X, Schofield, C.J.
Deposit date:2023-02-24
Release date:2024-02-28
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-flip Pocket for the Treatment of Obesity.
Angew.Chem.Int.Ed.Engl., 2024
8IHZ
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BU of 8ihz by Molmil
FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(1-(3-(4-chlorophenyl)propyl)-1H-1,2,3-triazol-4-yl)-3-hydroxypicolinoyl)glycine
Descriptor: 2-[[5-[1-[3-(4-chlorophenyl)propyl]-1,2,3-triazol-4-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ...
Authors:Nakashima, Y, Corner, T, Zhang, X, Schofield, C.J.
Deposit date:2023-02-24
Release date:2024-02-28
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-flip Pocket for the Treatment of Obesity.
Angew.Chem.Int.Ed.Engl., 2024
8GQ9
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BU of 8gq9 by Molmil
Crystal structure of lasso peptide epimerase MslH
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, GLYCEROL, ...
Authors:Nakashima, Y, Morita, H.
Deposit date:2022-08-29
Release date:2023-06-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism.
Nat Commun, 14, 2023
8GQA
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BU of 8gqa by Molmil
Crystal structure of lasso peptide epimerase MslH in complexed with precursor peptide analog MslAdeltaW21
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Poly-gamma-glutamate synthesis protein (Capsule biosynthesis protein), ...
Authors:Nakashima, Y, Morita, H.
Deposit date:2022-08-29
Release date:2023-06-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism.
Nat Commun, 14, 2023
8GQB
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BU of 8gqb by Molmil
Crystal structure of lasso peptide epimerase MslH D11A mutant
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Nakashima, Y, Morita, H.
Deposit date:2022-08-29
Release date:2023-06-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism.
Nat Commun, 14, 2023
8ITH
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BU of 8ith by Molmil
Crystal structure of lasso peptide epimerase MslH H295N
Descriptor: CALCIUM ION, GLYCEROL, Poly-gamma-glutamate synthesis protein (Capsule biosynthesis protein)
Authors:Nakashima, Y, Hiroyuki, M.
Deposit date:2023-03-22
Release date:2023-06-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism.
Nat Commun, 14, 2023
7A1O
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BU of 7a1o by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 4-ethyl-2-oxoglutarate, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER)
Descriptor: 4-ethyl-2-oxoglutarate, CONSENSUS ANKYRIN REPEAT DOMAIN, Hypoxia-inducible factor 1-alpha inhibitor, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7A1Q
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BU of 7a1q by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-(carboxycarbonyl)cyclopentane-1-carboxylic acid, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER)
Descriptor: 3-(carboxycarbonyl)cyclopentane-1-carboxylic acid, CONSENSUS ANKYRIN REPEAT DOMAIN, Hypoxia-inducible factor 1-alpha inhibitor, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7A1P
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BU of 7a1p by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 4-propyl-2-oxoglutarate, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER)
Descriptor: (4~{S})-2-oxidanylidene-4-propyl-pentanedioic acid, CONSENSUS ANKYRIN REPEAT DOMAIN, Hypoxia-inducible factor 1-alpha inhibitor, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7A1M
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BU of 7a1m by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-propyl-2-oxoglutarate
Descriptor: 3-propyl-2-oxoglutarate, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7A1N
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BU of 7a1n by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-methyl-2-oxoglutarate, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER)
Descriptor: (3~{S})-3-methyl-2-oxidanylidene-pentanedioic acid, CONSENSUS ANKYRIN REPEAT DOMAIN, Hypoxia-inducible factor 1-alpha inhibitor, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7A1L
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BU of 7a1l by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-methyl-2-oxoglutarate
Descriptor: (3~{S})-3-methyl-2-oxidanylidene-pentanedioic acid, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7A1J
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BU of 7a1j by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-(3-phenylpropyl)-2-oxoglutarate
Descriptor: 3-(3-phenylpropyl)-2-oxoglutarate, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7A1S
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BU of 7a1s by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-methyl-2-oxoglutarate, AND TANKYRASE-2 (TNKS2) FRAGMENT PEPTIDE (21-MER)
Descriptor: (3~{S})-3-methyl-2-oxidanylidene-pentanedioic acid, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7A1K
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BU of 7a1k by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-((9,9-dimethyl-9H-fluoren-2-yl)methyl)-2-oxoglutarate
Descriptor: 3-((9,9-dimethyl-9H-fluoren-2-yl)methyl)-2-oxoglutarate, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ...
Authors:Nakashima, Y, Brewitz, L, Schofield, C.J.
Deposit date:2020-08-13
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12, 2021
7BT2
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BU of 7bt2 by Molmil
Crystal structure of the SERCA2a in the E2.ATP state
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Kabashima, Y, Ogawa, H, Nakajima, R, Toyoshima, C.
Deposit date:2020-03-31
Release date:2020-07-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.00002861 Å)
Cite:What ATP binding does to the Ca2+pump and how nonproductive phosphoryl transfer is prevented in the absence of Ca2.
Proc.Natl.Acad.Sci.USA, 117, 2020
8K71
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BU of 8k71 by Molmil
Factor-inhibiting hypoxia-inducible factor in complex with Zn(II) and 2-(3-hydroxy-2-((2-((naphthalen-2-ylmethyl)sulfonyl)acetyl)imino)-2,3-dihydrothiazol-4-yl)acetic acid
Descriptor: 2-[(2~{Z})-2-[2-(naphthalen-2-ylmethylsulfonyl)ethanoylimino]-3-oxidanyl-1,3-thiazol-4-yl]ethanoic acid, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ...
Authors:Nakashima, Y, Corner, T.P, Teo, R.Z.R, Brewitz, L, Schofield, C.J.
Deposit date:2023-07-26
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structure-guided optimisation of N -hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-alpha.
Chem Sci, 14, 2023
8K72
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BU of 8k72 by Molmil
Factor-inhibiting hypoxia-inducible factor in complex with Zn(II) and 2-(3-hydroxy-2-((3-(phenylsulfonamido)propanoyl)imino)-2,3-dihydrothiazol-4-yl)acetic acid
Descriptor: 2-[(2~{Z})-3-oxidanyl-2-[3-(phenylsulfonylamino)propanoylimino]-1,3-thiazol-4-yl]ethanoic acid, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ...
Authors:Nakashima, Y, Corner, T.P, Teo, R.Z.R, Brewitz, L, Schofield, C.J.
Deposit date:2023-07-26
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure-guided optimisation of N -hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-alpha.
Chem Sci, 14, 2023
8K73
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BU of 8k73 by Molmil
Factor-inhibiting hypoxia-inducible factor in complex with Zn(II) and 2-(3-hydroxy-2-((1-(phenylsulfonyl)pyrrolidine-3-carbonyl)imino)-2,3-dihydrothiazol-4-yl)acetic acid
Descriptor: 2-[(2~{Z})-3-oxidanyl-2-[(3~{R})-1-(phenylsulfonyl)pyrrolidin-3-yl]carbonylimino-1,3-thiazol-4-yl]ethanoic acid, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ...
Authors:Nakashima, Y, Corner, T.P, Teo, R.Z.R, Brewitz, L, Schofield, C.J.
Deposit date:2023-07-26
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structure-guided optimisation of N -hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-alpha.
Chem Sci, 14, 2023
6RUJ
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BU of 6ruj by Molmil
Factor inhibiting HIF-1 alpha in complex with consensus ankyrin repeat domain-(d)3-hydroxy-Leu peptide
Descriptor: CONSENSUS ANKYRIN REPEAT DOMAIN-(D)3-hydroxy-Leu, Hypoxia-inducible factor 1-alpha inhibitor, N-OXALYLGLYCINE, ...
Authors:Nakashima, Y, McDonough, M.A, Schofield, C.J.
Deposit date:2019-05-28
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:A human protein hydroxylase that accepts D-residues
Commun Chem, 2020

222926

數據於2024-07-24公開中

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