8IHZ

FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(1-(3-(4-chlorophenyl)propyl)-1H-1,2,3-triazol-4-yl)-3-hydroxypicolinoyl)glycine

Summary for 8IHZ

• Entry DOI: 10.2210/pdb8ihz/pdb
• Descriptor: Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ZINC ION, ... (5 entities in total)
• Functional Keywords: factor-inhibiting hypoxia-inducible factor, fih, 2og dependent dioxygenase, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 42154.40

Authors

Nakashima, Y.,Corner, T.,Zhang, X.,Schofield, C.J. (deposition date: 2023-02-24, release date: 2024-02-28)

• Primary citation: Nakashima, Y.,Corner, T.,Zhang, X.,Schofield, C.J.; A small-molecule FIH inhibitor binding to a tyrosine-flip pocket ameliorates obesity and MAFLD; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.22 Å)