8K73
Factor-inhibiting hypoxia-inducible factor in complex with Zn(II) and 2-(3-hydroxy-2-((1-(phenylsulfonyl)pyrrolidine-3-carbonyl)imino)-2,3-dihydrothiazol-4-yl)acetic acid
Summary for 8K73
| Entry DOI | 10.2210/pdb8k73/pdb |
| Descriptor | Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, GLYCEROL, ... (6 entities in total) |
| Functional Keywords | factor-inhibiting hypoxia-inducible factor, fih, 2og dependent dioxygenase, oxidoreductase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 42122.24 |
| Authors | Nakashima, Y.,Corner, T.P.,Teo, R.Z.R.,Brewitz, L.,Schofield, C.J. (deposition date: 2023-07-26, release date: 2023-12-13) |
| Primary citation | Corner, T.P.,Teo, R.Z.R.,Wu, Y.,Salah, E.,Nakashima, Y.,Fiorini, G.,Tumber, A.,Brasnett, A.,Holt-Martyn, J.P.,Figg Jr., W.D.,Zhang, X.,Brewitz, L.,Schofield, C.J. Structure-guided optimisation of N -hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-alpha. Chem Sci, 14:12098-12120, 2023 Cited by PubMed: 37969593DOI: 10.1039/d3sc04253g PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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