8II0
FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(3-(3-chlorophenyl)isoxazol-5-yl)-3-hydroxypicolinoyl)glycine
Summary for 8II0
Entry DOI | 10.2210/pdb8ii0/pdb |
Descriptor | Hypoxia-inducible factor 1-alpha inhibitor, 2-[[5-[3-(3-chlorophenyl)-1,2-oxazol-5-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, GLYCEROL, ... (6 entities in total) |
Functional Keywords | factor-inhibiting hypoxia-inducible factor, fih, 2og dependent dioxygenase, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 41720.13 |
Authors | Nakashima, Y.,Corner, T.,Zhang, X.,Schofield, C.J. (deposition date: 2023-02-24, release date: 2024-02-28) |
Primary citation | Nakashima, Y.,Corner, T.,Zhang, X.,Schofield, C.J. A small-molecule FIH inhibitor binding to a tyrosine-flip pocket ameliorates obesity and MAFLD To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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