8II0

FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(3-(3-chlorophenyl)isoxazol-5-yl)-3-hydroxypicolinoyl)glycine

Summary for 8II0

Entry DOI	10.2210/pdb8ii0/pdb
Descriptor	Hypoxia-inducible factor 1-alpha inhibitor, 2-[[5-[3-(3-chlorophenyl)-1,2-oxazol-5-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, GLYCEROL, ... (6 entities in total)
Functional Keywords	factor-inhibiting hypoxia-inducible factor, fih, 2og dependent dioxygenase, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	41720.13
Authors	Nakashima, Y.,Corner, T.,Zhang, X.,Schofield, C.J. (deposition date: 2023-02-24, release date: 2024-02-28, Last modification date: 2024-07-10)
Primary citation	Wu, Y.,Chen, Y.,Corner, T.,Nakashima, Y.,Salah, E.,Li, Z.,Zhang, L.,Yang, L.,Tumber, A.,Sun, Z.,Wen, Y.,Zhong, A.,Yang, F.,Li, X.,Zhang, Z.,Schofield, C.,Zhang, X. A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-flip Pocket for the Treatment of Obesity. Angew.Chem.Int.Ed.Engl., :e202410438-e202410438, 2024 Cited by PubMed: 38923188 DOI: 10.1002/anie.202410438 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.04 Å)

Structure validation