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PDB: 163 件
7Q5V
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HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) IN COMPLEX WITH N-OXALYLGLYCINE (NOG) AND HIF-2 ALPHA CODD (523-542)
分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Egl nine homolog 1, ...
著者Figg Jr, W.D, McDonough, M.A, Chowdhury, R, Nakashima, Y, Schofield, C.J.
登録日2021-11-04
公開日2022-11-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.17 Å)
主引用文献Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2 alpha to prolyl hydroxylase domain 2.
Proteins, 91, 2023
1A0A
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PHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO4/DNA COMPLEX
分子名称: DNA (5'-D(*CP*TP*AP*GP*TP*CP*CP*CP*AP*CP*GP*TP*GP*TP*GP*AP*G )-3'), DNA (5'-D(*CP*TP*CP*AP*CP*AP*CP*GP*TP*GP*GP*GP*AP*CP*TP*AP*G )-3'), PROTEIN (PHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO4)
著者Shimizu, T, Toumoto, A, Ihara, K, Shimizu, M, Kyogoku, Y, Ogawa, N, Oshima, Y, Hakoshima, T.
登録日1997-11-27
公開日1998-03-18
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition.
EMBO J., 16, 1997
8H8Q
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Fab-amyloid beta fragment complex at neutral pH
分子名称: CHLORIDE ION, Fab, GLN-LYS-CYS-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-CYS-GLY, ...
著者Kita, A, Irie, K, Irie, Y, Matsushima, Y, Miki, K.
登録日2022-10-24
公開日2023-10-25
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Fab-amyloid beta fragment complex at neutral pH
To Be Published
5H0Q
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Crystal structure of lipid binding protein Nakanori at 1.5A
分子名称: Lipid binding protein
著者Makino, A, Abe, M, Ishitsuka, R, Murate, M, Kishimoto, T, Sakai, S, Hullin-Matsuda, F, Shimada, Y, Inaba, T, Miyatake, H, Tanaka, H, Kurahashi, A, Pack, C.G, Kasai, R.S, Kubo, S, Schieber, N.L, Dohmae, N, Tochio, N, Hagiwara, K, Sasaki, Y, Aida, Y, Fujimori, F, Kigawa, T, Nishikori, K, Parton, R.G, Kusumi, A, Sako, Y, Anderluh, G, Yamashita, M, Kobayashi, T, Greimel, P, Kobayashi, T.
登録日2016-10-06
公開日2016-10-19
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.501 Å)
主引用文献A novel sphingomyelin/cholesterol domain-specific probe reveals the dynamics of the membrane domains during virus release and in Niemann-Pick type C
FASEB J., 31, 2017
6ZBO
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HIF Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with 1-(6-morpholinopyrimidin-4-yl)-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-ol (Molidustat)
分子名称: 2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(1,2,3-triazol-1-yl)pyrazol-3-ol, CHLORIDE ION, Egl nine homolog 1, ...
著者Figg Jr, W.D, McDonough, M.A, Nakashima, Y, Holt-Martyn, J.P, Schofield, C.J.
登録日2020-06-08
公開日2021-04-07
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat.
Chemmedchem, 16, 2021
6ZBN
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HIF Prolyl Hydroxylase 2 (PHD2/EGLN1) in complex with tert-butyl 6-(5-hydroxy-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl)nicotinate (IOX4)
分子名称: Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ...
著者Figg Jr, W.D, McDonough, M.A, Nakashima, Y, Schofield, C.J.
登録日2020-06-08
公開日2021-04-07
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat.
Chemmedchem, 16, 2021
1EWT
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BU of 1ewt by Molmil
CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1 LIGAND FREE FORM I
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1, SULFATE ION
著者Kunishima, N, Shimada, Y, Tsuji, Y, Jingami, H, Morikawa, K.
登録日2000-04-27
公開日2000-12-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor.
Nature, 407, 2000
1EWV
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CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1 LIGAND FREE FORM II
分子名称: METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1
著者Kunishima, N, Shimada, Y, Tsuji, Y, Jingami, H, Morikawa, K.
登録日2000-04-27
公開日2000-12-18
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor.
Nature, 407, 2000
1EWK
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CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1 COMPLEXED WITH GLUTAMATE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLUTAMIC ACID, ...
著者Kunishima, N, Shimada, Y, Jingami, H, Morikawa, K.
登録日2000-04-26
公開日2000-12-18
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor.
Nature, 407, 2000
6IN4
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Crystal structure of apo DAPK1 in the presence of 18-crown-6
分子名称: Death-associated protein kinase 1, SULFATE ION
著者Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M.
登録日2018-10-24
公開日2019-10-30
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crown Ethers as Transthyretin Amyloidogenesis Inhibitor
To Be Published
6IMZ
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Crystal structure of MTH1 in complex with 18-Crown-6
分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, ...
著者Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M.
登録日2018-10-24
公開日2019-10-30
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crown Ethers as Transthyretin Amyloidogenesis Inhibitor
To Be Published
6IN0
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Crystal structure of EphA3 in complex with 18-Crown-6
分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, CHLORIDE ION, Ephrin type-A receptor 3
著者Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M.
登録日2018-10-24
公開日2019-10-30
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.501 Å)
主引用文献Crown Ethers as Transthyretin Amyloidogenesis Inhibitor
To Be Published
6IN3
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BU of 6in3 by Molmil
Crystal structure of DOT1L in complex with 18-Crown-6
分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ...
著者Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M.
登録日2018-10-24
公開日2019-10-30
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crown Ethers as Transthyretin Amyloidogenesis Inhibitor
To Be Published
6IN1
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BU of 6in1 by Molmil
Crystal structure of the first bromodomain of BRD4 in complex with 18-Crown-6
分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Bromodomain-containing protein 4, N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide, ...
著者Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M.
登録日2018-10-24
公開日2019-10-30
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crown Ethers as Transthyretin Amyloidogenesis Inhibitor
To Be Published
5ZV2
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BU of 5zv2 by Molmil
FGFR-1 in complex with ligand lenvatinib
分子名称: 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide, Fibroblast growth factor receptor 1
著者Matsuki, M, Hoshi, T, Yamamoto, Y, Ikemori-Kawada, M, Minoshima, Y, Funahashi, Y, Matsui, J.
登録日2018-05-09
公開日2018-07-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models.
Cancer Med, 7, 2018
2ZA6
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BU of 2za6 by Molmil
recombinant horse L-chain apoferritin
分子名称: CADMIUM ION, Ferritin light chain
著者Yamashita, I, Mishima, Y, Park, S.-Y, Heddle, J.G, Tame, J.R.H.
登録日2007-10-02
公開日2008-01-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Effect of N-terminal Residues on the Structural Stability of Recombinant Horse L-chain Apoferritin in an Acidic Environment
J.BIOCHEM.(TOKYO), 142, 2007
2ZA7
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recombinant horse L-chain apoferritin N-terminal deletion mutant (residues 1-4)
分子名称: Ferritin light chain
著者Yamashita, I, Mishima, Y, Park, S.-Y, Heddle, J.G, Tame, J.R.H.
登録日2007-10-02
公開日2008-01-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Effect of N-terminal Residues on the Structural Stability of Recombinant Horse L-chain Apoferritin in an Acidic Environment
J.BIOCHEM.(TOKYO), 142, 2007
3JAO
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BU of 3jao by Molmil
Ciliary microtubule doublet
分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
著者Maheshwari, A, Obbineni, J.M, Bui, K.H, Shibata, K, Toyoshima, Y.Y, Ishikawa, T.
登録日2015-06-18
公開日2015-08-05
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (23 Å)
主引用文献alpha- and beta-Tubulin Lattice of the Axonemal Microtubule Doublet and Binding Proteins Revealed by Single Particle Cryo-Electron Microscopy and Tomography.
Structure, 23, 2015
5X9S
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BU of 5x9s by Molmil
Crystal structure of fully modified H-Ras-GppNHp
分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
著者Matsumoto, S, Ke, H, Murashima, Y, Taniguchi-Tamura, H, Miyamoto, R, Yoshikawa, Y, Kumasaka, T, Mizohata, E, Edamatsu, H, Kataoka, T.
登録日2017-03-09
公開日2017-08-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for intramolecular interaction of post-translationally modified H-RasGTP prepared by protein ligation
FEBS Lett., 591, 2017
6IMX
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BU of 6imx by Molmil
Crystal structure of V30M mutated transthyretin in complex with 18-Crown-6
分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Transthyretin
著者Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M.
登録日2018-10-24
公開日2019-03-13
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.602 Å)
主引用文献Crown Ethers as Transthyretin Amyloidogenesis Inhibitors.
J. Med. Chem., 62, 2019
8I74
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Crystal structure of decarboxylated osteocalcin at pH 8.5
分子名称: Osteocalcin
著者Yokoyama, T, Nabeshima, Y, Obita, T, Mizuguchi, M.
登録日2023-01-31
公開日2024-01-31
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Crystal structures of decarboxylated osteocalcin and implications for the interaction with its receptor
To Be Published
8I75
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Crystal structure of decarboxylated osteocalcin at pH 2.0
分子名称: Osteocalcin
著者Yokoyama, T, Nabeshima, Y, Obita, T, Mizuguchi, M.
登録日2023-01-31
公開日2024-01-31
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Crystal structures of decarboxylated osteocalcin and implications for the interaction with its receptor
To Be Published
8I76
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Crystal structure of decarboxylated osteocalcin at pH 2.0 without glycerol
分子名称: Osteocalcin
著者Yokoyama, T, Nabeshima, Y, Obita, T, Mizuguchi, M.
登録日2023-01-31
公開日2024-01-31
実験手法X-RAY DIFFRACTION (1.381 Å)
主引用文献Crystal structures of decarboxylated osteocalcin and implications for the interaction with its receptor
To Be Published
2ZM8
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BU of 2zm8 by Molmil
Structure of 6-Aminohexanoate-dimer Hydrolase, S112A/D370Y Mutant Complexed with 6-Aminohexanoate-dimer
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOIC ACID, 6-aminohexanoate-dimer hydrolase, ...
著者Ohki, T, Shibata, N, Higuchi, Y, Kawashima, Y, Takeo, M, Kato, D, Negoro, S.
登録日2008-04-14
公開日2009-04-14
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Two alternative modes for optimizing nylon-6 byproduct hydrolytic activity from a carboxylesterase with a beta-lactamase fold: X-ray crystallographic analysis of directly evolved 6-aminohexanoate-dimer hydrolase.
Protein Sci., 18, 2009
2ZA8
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recombinant horse L-chain apoferritin N-terminal deletion mutant (residues 1-8)
分子名称: CADMIUM ION, Ferritin light chain
著者Yamashita, I, Mishima, Y, Park, S.-Y, Heddle, J.G, Tame, J.R.H.
登録日2007-10-02
公開日2008-01-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Effect of N-terminal Residues on the Structural Stability of Recombinant Horse L-chain Apoferritin in an Acidic Environment
J.BIOCHEM.(TOKYO), 142, 2007

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