5ZV2

FGFR-1 in complex with ligand lenvatinib

Summary for 5ZV2

Entry DOI	10.2210/pdb5zv2/pdb
Descriptor	Fibroblast growth factor receptor 1, 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide (3 entities in total)
Functional Keywords	fgf receptor kinase, transferase-transferase inhibitor complex, biosynthetic protein, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	70503.82
Authors	Matsuki, M.,Hoshi, T.,Yamamoto, Y.,Ikemori-Kawada, M.,Minoshima, Y.,Funahashi, Y.,Matsui, J. (deposition date: 2018-05-09, release date: 2018-07-11, Last modification date: 2023-11-22)
Primary citation	Matsuki, M.,Hoshi, T.,Yamamoto, Y.,Ikemori-Kawada, M.,Minoshima, Y.,Funahashi, Y.,Matsui, J. Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models. Cancer Med, 7:2641-2653, 2018 Cited by PubMed: 29733511 DOI: 10.1002/cam4.1517 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.86 Å)

Structure validation