5ZV2
FGFR-1 in complex with ligand lenvatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fibroblast growth factor receptor 1 | polymer | 305 | 34825.1 | 2 | UniProt (P11362) Pfam (PF07714) | Homo sapiens (Human) | FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr |
| 2 | C, D (A, B) | 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide | non-polymer | 426.9 | 2 | Chemie (LEV) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, B: 461 - 764 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Ser 460 | - | expression tag |
| Ala 488 | Cys 488 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69650.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 853.7 | |
| All* | Total formula weight | 70503.8 |
