5B2R
| Crystal structure of the Streptococcus pyogenes Cas9 VQR variant in complex with sgRNA and target DNA (TGA PAM) | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CRISPR-associated endonuclease Cas9, ... | Authors: | Hirano, S, Nishimasu, H, Ishitani, R, Nureki, O. | Deposit date: | 2016-02-02 | Release date: | 2016-03-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas9 Mol.Cell, 61, 2016
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7XHT
| Structure of the OgeuIscB-omega RNA-target DNA complex | Descriptor: | DNA (49-MER), DNA (5'-D(P*GP*AP*AP*GP*AP*AP*AP*AP*CP*CP*AP*T)-3'), LAURYL DIMETHYLAMINE-N-OXIDE, ... | Authors: | Kato, K, Okazaki, O, Isayama, Y, Ishikawa, J, Nishizawa, T, Nishimasu, H. | Deposit date: | 2022-04-10 | Release date: | 2022-12-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | Structure of the IscB-omega RNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9. Nat Commun, 13, 2022
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6KR6
| Crystal structure of Drosophila Piwi | Descriptor: | MERCURY (II) ION, Protein piwi, ZINC ION, ... | Authors: | Yamaguchi, S, Oe, A, Yamashita, K, Hirano, S, Mastumoto, N, Ishitani, R, Nishimasu, H, Nureki, O. | Deposit date: | 2019-08-21 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of Drosophila Piwi. Nat Commun, 11, 2020
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6L96
| Structure of PPARalpha-LBD/pemafibrate/SRC1 peptide | Descriptor: | (2~{R})-2-[3-[[1,3-benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoic acid, Peroxisome proliferator-activated receptor alpha, SRC1 coactivator peptide | Authors: | Kawasaki, M, Kambe, A, Yamamoto, Y, Arulmozhira, S, Ito, S, Nakagawa, Y, Tokiwa, H, Nakano, S, Shimano, H. | Deposit date: | 2019-11-08 | Release date: | 2020-01-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Elucidation of Molecular Mechanism of a Selective PPAR alpha Modulator, Pemafibrate, through Combinational Approaches of X-ray Crystallography, Thermodynamic Analysis, and First-Principle Calculations. Int J Mol Sci, 21, 2020
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4IYS
| Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4 | Descriptor: | Metal transporter CNNM2 | Authors: | Corral-Rodriguez, M.A, Stuiver, M, Encinar, J.A, Spiwok, V, Gomez-Garcia, I, Oyenarte, I, Ereno-Orbea, J, Terashima, H, Accardi, A, Diercks, T, Muller, D, Martinez-Cruz, L.A. | Deposit date: | 2013-01-29 | Release date: | 2014-03-05 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4 To be Published
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4IY2
| Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4 | Descriptor: | Metal transporter CNNM2 | Authors: | Corral-Rodriguez, M.A, Stuiver, M, Encinar, J.A, Spiwok, V, Gomez-Garcia, I, Oyenarte, I, Ereno-Orbea, J, Terashima, H, Accardi, A, Diercks, T, Muller, D, Martinez-Cruz, L.A. | Deposit date: | 2013-01-28 | Release date: | 2014-03-05 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4 To be Published
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4IY0
| Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4 | Descriptor: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, Metal transporter CNNM2 | Authors: | Corral-Rodriguez, M.A, Stuiver, M, Encinar, J.A, Spiwok, V, Gomez-Garcia, I, Oyenarte, I, Ereno-Orbea, J, Terashima, H, Accardi, A, Diercks, T, Muller, D, Martinez-Cruz, L.A. | Deposit date: | 2013-01-28 | Release date: | 2014-03-05 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4 To be Published
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4IY4
| Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4 | Descriptor: | Metal transporter CNNM2 | Authors: | Corral-Rodriguez, M.A, Stuiver, M, Encinar, J.A, Spiwok, V, Gomez-Garcia, I, Oyenarte, I, Ereno-Orbea, J, Terashima, H, Accardi, A, Diercks, T, Muller, D, Martinez-Cruz, L.A. | Deposit date: | 2013-01-28 | Release date: | 2014-03-12 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4 To be Published
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4WFI
| Crystal structure of PET-degrading cutinase Cut190 S226P mutant in Ca(2+)-free state | Descriptor: | Cutinase | Authors: | Miyakawa, T, Mizushima, H, Ohtsuka, J, Oda, M, Kawai, F, Tanokura, M. | Deposit date: | 2014-09-15 | Release date: | 2014-12-24 | Last modified: | 2020-01-29 | Method: | X-RAY DIFFRACTION (1.446 Å) | Cite: | Structural basis for the Ca(2+)-enhanced thermostability and activity of PET-degrading cutinase-like enzyme from Saccharomonospora viridis AHK190. Appl.Microbiol.Biotechnol., 99, 2015
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7Y9Y
| Structure of the Cas7-11-Csx29-guide RNA-target RNA (no PFS) complex | Descriptor: | CHAT domain-containing protein, CRISPR-associated RAMP family protein, RNA (27-MER), ... | Authors: | Kato, K, Okazaki, S, Ishikawa, J, Isayama, Y, Nishizawa, T, Nishimasu, H. | Deposit date: | 2022-06-26 | Release date: | 2022-11-09 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | RNA-triggered protein cleavage and cell growth arrest by the type III-E CRISPR nuclease-protease. Science, 378, 2022
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7V6B
| Structure of the Dicer-2-R2D2 heterodimer | Descriptor: | Dicer-2, isoform A, R2D2 | Authors: | Yamaguchi, S, Nishizawa, T, Kusakizako, T, Yamashita, K, Tomita, A, Hirano, H, Nishimasu, H, Nureki, O. | Deposit date: | 2021-08-20 | Release date: | 2022-03-23 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex. Nature, 607, 2022
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7V6C
| Structure of the Dicer-2-R2D2 heterodimer bound to small RNA duplex | Descriptor: | Dicer-2, isoform A, R2D2, ... | Authors: | Yamaguchi, S, Nishizawa, T, Kusakizako, T, Yamashita, K, Tomita, A, Hirano, H, Nishimasu, H, Nureki, O. | Deposit date: | 2021-08-20 | Release date: | 2022-03-23 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex. Nature, 607, 2022
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4WFJ
| Crystal structure of PET-degrading cutinase Cut190 S226P mutant in Ca(2+)-bound state at 1.75 angstrom resolution | Descriptor: | CALCIUM ION, CHLORIDE ION, Cutinase | Authors: | Miyakawa, T, Mizushima, H, Ohtsuka, J, Oda, M, Kawai, F, Tanokura, M. | Deposit date: | 2014-09-15 | Release date: | 2014-12-24 | Last modified: | 2020-01-29 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural basis for the Ca(2+)-enhanced thermostability and activity of PET-degrading cutinase-like enzyme from Saccharomonospora viridis AHK190. Appl.Microbiol.Biotechnol., 99, 2015
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4WFK
| Crystal structure of PET-degrading cutinase Cut190 S226P mutant in Ca(2+)-bound state at 2.35 angstrom resolution | Descriptor: | CALCIUM ION, CHLORIDE ION, Cutinase | Authors: | Miyakawa, T, Mizushima, H, Ohtsuka, J, Oda, M, Kawai, F, Tanokura, M. | Deposit date: | 2014-09-15 | Release date: | 2014-12-24 | Last modified: | 2020-01-29 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural basis for the Ca(2+)-enhanced thermostability and activity of PET-degrading cutinase-like enzyme from Saccharomonospora viridis AHK190. Appl.Microbiol.Biotechnol., 99, 2015
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1V6C
| Crystal Structure of Psychrophilic Subtilisin-like Protease Apa1 from Antarctic Psychrotroph Pseudoalteromonas sp. AS-11 | Descriptor: | CALCIUM ION, SULFATE ION, alkaline serine protease, ... | Authors: | Dong, D, Ihara, T, Motoshima, H, Watanabe, K. | Deposit date: | 2003-11-28 | Release date: | 2004-12-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of Psychrophilic Subtilisin-like Protease Apa1 from Antarctic Psychrotroph Pseudoalteromonas sp. AS-11 To be Published
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6IS0
| Crystal structure of the zebrafish cap-specific adenosine methyltransferase bound to SAH and m7G-capped RNA | Descriptor: | 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Hirano, S, Nishimasu, H, Ishitani, R, Nureki, O. | Deposit date: | 2018-11-15 | Release date: | 2018-12-05 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II-associated methyltransferase. Science, 363, 2019
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5XUU
| Crystal structure of Lachnospiraceae bacterium ND2006 Cpf1 in complex with crRNA and target DNA (TCCA PAM) | Descriptor: | 1,2-ETHANEDIOL, DNA (29-MER), DNA (5'-D(*CP*GP*TP*CP*CP*TP*CP*CP*A)-3'), ... | Authors: | Yamano, T, Nishimasu, H, Ishitani, R, Nureki, O. | Deposit date: | 2017-06-26 | Release date: | 2017-08-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1. Mol. Cell, 67, 2017
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5XUS
| Crystal structure of Lachnospiraceae bacterium ND2006 Cpf1 in complex with crRNA and target DNA (TTTA PAM) | Descriptor: | 1,2-ETHANEDIOL, DNA (29-MER), DNA (5'-D(*CP*GP*TP*CP*CP*TP*TP*TP*A)-3'), ... | Authors: | Yamano, T, Nishimasu, H, Ishitani, R, Nureki, O. | Deposit date: | 2017-06-26 | Release date: | 2017-08-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1. Mol. Cell, 67, 2017
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1V6A
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5XUT
| Crystal structure of Lachnospiraceae bacterium ND2006 Cpf1 in complex with crRNA and target DNA (TCTA PAM) | Descriptor: | 1,2-ETHANEDIOL, DNA (29-MER), DNA (5'-D(*CP*GP*TP*CP*CP*TP*CP*TP*A)-3'), ... | Authors: | Yamano, T, Nishimasu, H, Ishitani, R, Nureki, O. | Deposit date: | 2017-06-26 | Release date: | 2017-08-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1. Mol. Cell, 67, 2017
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6JOO
| Crystal structure of Corynebacterium diphtheriae Cas9 in complex with sgRNA and target DNA | Descriptor: | 1,2-ETHANEDIOL, CRISPR-associated protein,CRISPR-associated endonuclease Cas9, Guide RNA, ... | Authors: | Hirano, S, Ishitani, R, Nishimasu, H, Nureki, O. | Deposit date: | 2019-03-22 | Release date: | 2019-04-17 | Last modified: | 2019-05-15 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9. Nat Commun, 10, 2019
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2Z87
| Crystal structure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GalNAc and UDP | Descriptor: | Chondroitin synthase, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ... | Authors: | Osawa, T, Sugiura, N, Shimada, H, Hirooka, R, Tsuji, A, Kimura, M, Kimata, K, Kakuta, Y. | Deposit date: | 2007-09-03 | Release date: | 2008-09-16 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of chondroitin polymerase from Escherichia coli K4. Biochem. Biophys. Res. Commun., 378, 2009
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7WAH
| Structure of Cas7-11 in complex with guide RNA and target RNA | Descriptor: | CRISPR-associated RAMP family protein, ZINC ION, crRNA (39-MER), ... | Authors: | Kato, K, Okazaki, S, Isayama, Y, Nishizawa, T, Nishimasu, H. | Deposit date: | 2021-12-14 | Release date: | 2022-06-15 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.45 Å) | Cite: | Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex. Cell, 185, 2022
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7Y9X
| Structure of the Cas7-11-Csx29-guide RNA complex | Descriptor: | CHAT domain-containing protein, CRISPR-associated RAMP family protein, ZINC ION, ... | Authors: | Kato, K, Okazaki, S, Ishikawa, J, Isayama, Y, Nishizawa, T, Nishimasu, H. | Deposit date: | 2022-06-26 | Release date: | 2022-11-09 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.49 Å) | Cite: | RNA-triggered protein cleavage and cell growth arrest by the type III-E CRISPR nuclease-protease. Science, 378, 2022
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2Z86
| Crystal structure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GlcUA and UDP | Descriptor: | Chondroitin synthase, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ... | Authors: | Osawa, T, Sugiura, N, Shimada, H, Hirooka, R, Tsuji, A, Kimura, M, Kimata, K, Kakuta, Y. | Deposit date: | 2007-09-03 | Release date: | 2008-09-16 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of chondroitin polymerase from Escherichia coli K4. Biochem. Biophys. Res. Commun., 378, 2009
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