6L96

Structure of PPARalpha-LBD/pemafibrate/SRC1 peptide

Summary for 6L96

Entry DOI	10.2210/pdb6l96/pdb
Descriptor	Peroxisome proliferator-activated receptor alpha, SRC1 coactivator peptide, (2~{R})-2-[3-[[1,3-benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoic acid (3 entities in total)
Functional Keywords	transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	64835.42
Authors	Kawasaki, M.,Kambe, A.,Yamamoto, Y.,Arulmozhira, S.,Ito, S.,Nakagawa, Y.,Tokiwa, H.,Nakano, S.,Shimano, H. (deposition date: 2019-11-08, release date: 2020-01-15, Last modification date: 2023-11-22)
Primary citation	Kawasaki, M.,Kambe, A.,Yamamoto, Y.,Arulmozhiraja, S.,Ito, S.,Nakagawa, Y.,Tokiwa, H.,Nakano, S.,Shimano, H. Elucidation of Molecular Mechanism of a Selective PPAR alpha Modulator, Pemafibrate, through Combinational Approaches of X-ray Crystallography, Thermodynamic Analysis, and First-Principle Calculations. Int J Mol Sci, 21:-, 2020 Cited by PubMed: 31935812 DOI: 10.3390/ijms21010361 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation