6J6N
| Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2019-01-15 | Release date: | 2019-04-24 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
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6J6Q
| Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2019-01-15 | Release date: | 2019-04-24 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
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5ZWM
| Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.4~4.6 angstrom (tri-snRNP and U2 snRNP Part) | Descriptor: | 13 kDa ribonucleoprotein-associated protein, 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component, Cold sensitive U2 snRNA suppressor 1, ... | Authors: | Bai, R, Wan, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2018-05-16 | Release date: | 2018-08-29 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation Science, 360, 2018
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6KLC
| Structure of apo Lassa virus polymerase | Descriptor: | MANGANESE (II) ION, RNA-directed RNA polymerase L | Authors: | Peng, R, Xu, X, Jing, J, Peng, Q, Gao, G.F, Shi, Y. | Deposit date: | 2019-07-30 | Release date: | 2020-03-18 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural insight into arenavirus replication machinery. Nature, 579, 2020
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5YGH
| Crystal Structure of the Capsid Protein from Zika Virus | Descriptor: | Capsid protein | Authors: | Shang, Z, Song, H, Shi, Y, Qi, J, Gao, G.F. | Deposit date: | 2017-09-23 | Release date: | 2018-02-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.884 Å) | Cite: | Crystal Structure of the Capsid Protein from Zika Virus. J. Mol. Biol., 430, 2018
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6KMS
| Crystal structure of human N6amt1-Trm112 in complex with SAM (space group I422) | Descriptor: | Methyltransferase N6AMT1, Multifunctional methyltransferase subunit TRM112-like protein, S-ADENOSYLMETHIONINE | Authors: | Li, W.J, Shi, Y, Zhang, T.L, Ye, J, Ding, J.P. | Deposit date: | 2019-08-01 | Release date: | 2019-09-18 | Last modified: | 2019-11-06 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural insight into human N6amt1-Trm112 complex functioning as a protein methyltransferase. Cell Discov, 5, 2019
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6KMR
| Crystal structure of human N6amt1-Trm112 in complex with SAM (space group P6122) | Descriptor: | 1,2-ETHANEDIOL, Methyltransferase N6AMT1, Multifunctional methyltransferase subunit TRM112-like protein, ... | Authors: | Li, W.J, Shi, Y, Zhang, T.L, Ye, J, Ding, J.P. | Deposit date: | 2019-08-01 | Release date: | 2019-09-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural insight into human N6amt1-Trm112 complex functioning as a protein methyltransferase. Cell Discov, 5, 2019
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7D7E
| Structure of PKD1L3-CTD/PKD2L1 in apo state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Polycystic kidney disease 2-like 1 protein, ... | Authors: | Su, Q, Chen, M, Li, B, Wang, Y, Jing, D, Zhan, X, Yu, Y, Shi, Y. | Deposit date: | 2020-10-03 | Release date: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for Ca 2+ activation of the heteromeric PKD1L3/PKD2L1 channel. Nat Commun, 12, 2021
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6AJK
| Crystal structure of TFB1M and h45 in homo sapiens | Descriptor: | Dimethyladenosine transferase 1, mitochondrial, RNA (28-MER) | Authors: | Liu, X, Shen, S, Wu, P, Li, F, Wang, C, Gong, Q, Wu, J, Zhang, H, Shi, Y. | Deposit date: | 2018-08-28 | Release date: | 2019-06-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.001 Å) | Cite: | Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. Nucleic Acids Res., 47, 2019
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1MR1
| Crystal Structure of a Smad4-Ski Complex | Descriptor: | Mothers against decapentaplegic homolog 4, Ski oncogene, ZINC ION | Authors: | Wu, J.-W, Krawitz, A.R, Chai, J, Li, W, Zhang, F, Luo, K, Shi, Y. | Deposit date: | 2002-09-17 | Release date: | 2003-01-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural Mechanism of Smad4 Recognition by the Nuclear Oncoprotein Ski: Insights on Ski-mediated Repression of TGF-beta Signaling Cell(Cambridge,Mass.), 111, 2002
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7BCS
| ASCT2 in the presence of the inhibitor Lc-BPE (position "down") in the outward-open conformation. | Descriptor: | (2~{S},4~{S})-4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0) | Authors: | Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A. | Deposit date: | 2020-12-21 | Release date: | 2021-09-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118, 2021
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1NB8
| Structure of the catalytic domain of USP7 (HAUSP) | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 7 | Authors: | Hu, M, Li, P, Li, M, Li, W, Yao, T, Wu, J.-W, Gu, W, Cohen, R.E, Shi, Y. | Deposit date: | 2002-12-02 | Release date: | 2003-01-07 | Last modified: | 2018-04-04 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde Cell(Cambridge,Mass.), 111, 2002
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1NBF
| Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde | Descriptor: | Ubiquitin aldehyde, Ubiquitin carboxyl-terminal hydrolase 7 | Authors: | Hu, M, Li, P, Li, M, Li, W, Yao, T, Wu, J.-W, Gu, W, Cohen, R.E, Shi, Y. | Deposit date: | 2002-12-02 | Release date: | 2003-01-07 | Last modified: | 2018-10-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde Cell(Cambridge,Mass.), 111, 2002
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7EXS
| Thermomicrobium roseum sarcosine oxidase mutant - S320R | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Xin, Y, Shen, C, Tang, M.W, Shi, Y, Guo, Z.T, Gu, Z.H, Shao, J, Zhang, L. | Deposit date: | 2021-05-28 | Release date: | 2021-07-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Recreating the natural evolutionary trend in key microdomains provides an effective strategy for engineering of a thermomicrobial N-demethylase. J.Biol.Chem., 298, 2022
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6AAX
| Crystal structure of TFB1M and h45 with SAM in homo sapiens | Descriptor: | DI(HYDROXYETHYL)ETHER, Dimethyladenosine transferase 1, mitochondrial, ... | Authors: | Liu, X, Shen, S, Wu, P, Li, F, Gong, Q, Wu, J, Zhang, H, Shi, Y. | Deposit date: | 2018-07-19 | Release date: | 2019-06-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.994 Å) | Cite: | Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. Nucleic Acids Res., 47, 2019
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7CKM
| Structure of Machupo virus polymerase bound to Z matrix protein (monomeric complex) | Descriptor: | MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | Authors: | Xu, X, Peng, R, Peng, Q, Shi, Y. | Deposit date: | 2020-07-17 | Release date: | 2021-05-05 | Last modified: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals Nat Microbiol, 6, 2021
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7CKL
| Structure of Lassa virus polymerase bound to Z matrix protein | Descriptor: | MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | Authors: | Xu, X, Peng, R, Peng, Q, Shi, Y. | Deposit date: | 2020-07-17 | Release date: | 2021-05-05 | Last modified: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals Nat Microbiol, 6, 2021
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7ELB
| Structure of Machupo virus L polymerase in complex with Z protein (dimeric form) | Descriptor: | MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | Authors: | Peng, R, Xu, X, Peng, Q, Shi, Y. | Deposit date: | 2021-04-09 | Release date: | 2021-05-05 | Last modified: | 2021-07-14 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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7ELC
| Structure of monomeric complex of MACV L bound to Z and 3'-vRNA | Descriptor: | 3'-vRNA promoter, MANGANESE (II) ION, RING finger protein Z, ... | Authors: | Xu, X, Peng, R, Peng, Q, Shi, Y. | Deposit date: | 2021-04-09 | Release date: | 2021-05-05 | Last modified: | 2021-07-14 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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7ELA
| Structure of Lassa virus polymerase in complex with 3'-vRNA and Z mutant (F36A) | Descriptor: | 3-'vRNA promoter, MANGANESE (II) ION, RING finger protein Z, ... | Authors: | Xu, X, Peng, R, Peng, Q, Shi, Y. | Deposit date: | 2021-04-09 | Release date: | 2021-05-05 | Last modified: | 2021-07-14 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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7EL9
| Structure of Machupo virus L polymerase in complex with Z protein and 3'-vRNA (dimeric complex) | Descriptor: | MANGANESE (II) ION, Machupo virus 3'-vRNA promoter, RING finger protein Z, ... | Authors: | Peng, R, Xu, X, Peng, Q, Shi, Y. | Deposit date: | 2021-04-09 | Release date: | 2021-05-05 | Last modified: | 2021-07-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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1OZJ
| Crystal structure of Smad3-MH1 bound to DNA at 2.4 A resolution | Descriptor: | SMAD 3, Smad binding element, ZINC ION | Authors: | Chai, J, Wu, J.-W, Yan, N, Massague, J, Pavletich, N.P, Shi, Y. | Deposit date: | 2003-04-09 | Release date: | 2004-03-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding. J.Biol.Chem., 278, 2003
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1SJ6
| NMR Structure and Regulated Expression in APL Cell of Human SH3BGRL3 | Descriptor: | SH3 domain-binding glutamic acid-rich-like protein 3 | Authors: | Xu, C, Tang, Y, Xu, Y, Wu, J, Shi, Y, Zhang, Q, Zheng, P, Du, Y. | Deposit date: | 2004-03-03 | Release date: | 2005-03-22 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | NMR structure and regulated expression in APL cell of human SH3BGRL3. Febs Lett., 579, 2005
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7BW4
| Structure of the RNA-dependent RNA polymerase from SARS-CoV-2 | Descriptor: | Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ... | Authors: | Peng, Q, Peng, R, Shi, Y. | Deposit date: | 2020-04-13 | Release date: | 2020-05-27 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2. Cell Rep, 31, 2020
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1Z6T
| Structure of the apoptotic protease-activating factor 1 bound to ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Apoptotic protease activating factor 1 | Authors: | Riedl, S.J, Li, W, Chao, Y, Schwarzenbacher, R, Shi, Y. | Deposit date: | 2005-03-23 | Release date: | 2005-04-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structure of the apoptotic protease-activating factor 1 bound to ADP Nature, 434, 2005
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