7EL9

Structure of Machupo virus L polymerase in complex with Z protein and 3'-vRNA (dimeric complex)

Summary for 7EL9

• Entry DOI: 10.2210/pdb7el9/pdb
• EMDB information: 31177
• Descriptor: RNA-directed RNA polymerase L, RING finger protein Z, Machupo virus 3'-vRNA promoter, ... (5 entities in total)
• Functional Keywords: rna virus, polymerase, replication, transcription, matrix protein, viral protein-rna complex, viral protein/rna
• Biological source: Machupo mammarenavirus (MACV); More
• Total number of polymer chains: 6
• Total formula weight: 534925.10

Authors

Peng, R.,Xu, X.,Peng, Q.,Shi, Y. (deposition date: 2021-04-09, release date: 2021-05-05, Last modification date: 2021-07-14)

• Primary citation: Xu, X.,Peng, R.,Peng, Q.,Wang, M.,Xu, Y.,Liu, S.,Tian, X.,Deng, H.,Tong, Y.,Hu, X.,Zhong, J.,Wang, P.,Qi, J.,Gao, G.F.,Shi, Y.; Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals.; Nat Microbiol, 6:921-931, 2021; PubMed: 34127846; DOI: 10.1038/s41564-021-00916-w

Experimental method

ELECTRON MICROSCOPY (3.2 Å)