Crystal Structure of a Smad4-Ski Complex

Summary for 1MR1

DescriptorMothers against decapentaplegic homolog 4, Ski oncogene, ZINC ION, ... (4 entities in total)
Functional Keywordssmad, ski, cancer, tgf-b signaling, protein interaction, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q13485
Nucleus P12755
Total number of polymer chains4
Total molecular weight74453.8
Wu, J.-W.,Krawitz, A.R.,Chai, J.,Li, W.,Zhang, F.,Luo, K.,Shi, Y. (deposition date: 2002-09-17, release date: 2003-01-21, Last modification date: 2011-07-13)
Primary citation
Wu, J.-W.,Krawitz, A.R.,Chai, J.,Li, W.,Zhang, F.,Luo, K.,Shi, Y.
Structural Mechanism of Smad4 Recognition by the Nuclear Oncoprotein Ski: Insights on Ski-mediated Repression of TGF-beta Signaling
Cell(Cambridge,Mass.), 111:357-367, 2002
PubMed: 12419246 (PDB entries with the same primary citation)
DOI: 10.1016/S0092-8674(02)01006-1
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers29 4.9% 10.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02