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PDB: 1032 件
7TZK
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EPS8 SH3 Domain with NleH1 PxxDY Motif
分子名称: Epidermal growth factor receptor kinase substrate 8, T3SS secreted effector NleH homolog
著者Grishin, A.M, Cygler, M.
登録日2022-02-15
公開日2022-07-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Targeting of microvillus protein Eps8 by the NleH effector kinases from enteropathogenic E. coli
Proc.Natl.Acad.Sci.USA, 119, 2022
5I4N
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BU of 5i4n by Molmil
Crystal Structure of the E596A V617F Mutant JAK2 Pseudokinase Domain Bound to Mg-ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
著者Shiau, A.K, Motamedi, A.
登録日2016-02-12
公開日2016-04-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 alpha C helix.
Biochem.J., 473, 2016
1GLM
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BU of 1glm by Molmil
REFINED CRYSTAL STRUCTURES OF GLUCOAMYLASE FROM ASPERGILLUS AWAMORI VAR. X100
分子名称: GLUCOAMYLASE-471, alpha-D-mannopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Aleshin, A.E, Hoffman, C, Firsov, L.M, Honzatko, R.B.
登録日1994-04-25
公開日1994-06-22
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Refined crystal structures of glucoamylase from Aspergillus awamori var. X100.
J.Mol.Biol., 238, 1994
3MJG
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BU of 3mjg by Molmil
The structure of a platelet derived growth factor receptor complex
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-type platelet-derived growth factor receptor, ...
著者Shim, A.H.R, He, X.
登録日2010-04-12
公開日2010-06-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.
Proc.Natl.Acad.Sci.USA, 107, 2010
4BYI
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BU of 4byi by Molmil
Aurora A kinase bound to a highly selective imidazopyridine inhibitor
分子名称: (S)-N-((1-(6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-3-yl)methyl)acetamide, AURORA KINASE A
著者Joshi, A, Kosmopoulou, M, Bayliss, R.
登録日2013-07-19
公開日2013-11-20
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-B]Pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells.
J.Med.Chem., 56, 2013
2YZ1
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BU of 2yz1 by Molmil
Crystal structure of the ligand-binding domain of murine SHPS-1/SIRP alpha
分子名称: Tyrosine-protein phosphatase non-receptor type substrate 1
著者Nakaishi, A.
登録日2007-05-02
公開日2007-12-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural insight into the specific interaction between murine SHPS-1/SIRP alpha and its ligand CD47
J.Mol.Biol., 375, 2008
4WU5
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BU of 4wu5 by Molmil
HLA-A24 in complex with HIV-1 Nef134-8(wt)
分子名称: 8-Mer peptide from Protein Nef, Beta-2-microglobulin, HLA class I histocompatibility antigen, ...
著者Shimizu, A, Yamagata, A, Fukai, S, Iwamoto, A.
登録日2014-10-31
公開日2015-05-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of Nef134-8(wt) epitope presented by HLA-A24
To Be Published
4WU7
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HLA-A24 in complex with HIV-1 Nef134-8(2F)
分子名称: 8-Mer peptide from Protein Nef, Beta-2-microglobulin, HLA class I histocompatibility antigen, ...
著者Shimizu, A, Yamagata, A, Fukai, S, Iwamoto, A.
登録日2014-10-31
公開日2015-05-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.297 Å)
主引用文献Crystal structure of Nef134-8 epitope presented by HLA-A24
To Be Published
4YUR
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BU of 4yur by Molmil
Crystal Structure of Plk4 Kinase Domain Bound to Centrinone
分子名称: 2-({2-fluoro-4-[(2-fluoro-3-nitrobenzyl)sulfonyl]phenyl}sulfanyl)-5-methoxy-N-(3-methyl-1H-pyrazol-5-yl)-6-(morpholin-4-yl)pyrimidin-4-amine, Serine/threonine-protein kinase PLK4
著者Shiau, A.K, Motamedi, A.
登録日2015-03-19
公開日2015-06-17
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.
Science, 348, 2015
4Z7H
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Crystal structure of human IRE1 cytoplasmic kinase-RNase region - complex with imidazopyridine compound 3
分子名称: 2-methoxy-4-[6-(propan-2-ylamino)imidazo[1,2-b]pyridazin-3-yl]benzamide, SULFATE ION, Serine/threonine-protein kinase/endoribonuclease IRE1
著者Joshi, A, Bayliss, R.
登録日2015-04-07
公開日2015-05-27
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Molecular mechanisms of human IRE1 activation through dimerization and ligand binding.
Oncotarget, 6, 2015
1HKC
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BU of 1hkc by Molmil
RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND PHOSPHATE
分子名称: D-GLUCOSE 6-PHOSPHOTRANSFERASE, PHOSPHATE ION, POTASSIUM ION, ...
著者Aleshin, A.E, Honzatko, R.B.
登録日1998-07-01
公開日1998-11-11
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate.
J.Mol.Biol., 282, 1998
4BYJ
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Aurora A kinase bound to a highly selective imidazopyridine inhibitor
分子名称: (S)-N-(1-(6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-3-yl)acetamide, AURORA KINASE A
著者Joshi, A, Kosmopoulou, M, Bayliss, R.
登録日2013-07-19
公開日2013-11-20
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-B]Pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells.
J.Med.Chem., 56, 2013
6JUW
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BU of 6juw by Molmil
BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION
分子名称: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ...
著者Shimada, A, Muramoto, K, Shinzawa-Itoh, K, Yoshikawa, S, Tsukihara, T.
登録日2019-04-15
公開日2020-03-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献X-ray structures of catalytic intermediates of cytochromecoxidase provide insights into its O2activation and unidirectional proton-pump mechanisms.
J.Biol.Chem., 295, 2020
1HKB
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BU of 1hkb by Molmil
CRYSTAL STRUCTURE OF RECOMBINANT HUMAN BRAIN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND GLUCOSE-6-PHOSPHATE
分子名称: 6-O-phosphono-alpha-D-glucopyranose, CALCIUM ION, D-GLUCOSE 6-PHOSPHOTRANSFERASE, ...
著者Aleshin, A.E, Zeng, C, Burenkov, G.P, Bartunik, H.D, Fromm, H.J, Honzatko, R.B.
登録日1997-12-01
公開日1998-06-03
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate.
Structure, 6, 1998
5AWS
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BU of 5aws by Molmil
Crystal structure of the SGIP1 mu homology domain in the P1 space group
分子名称: SH3-containing GRB2-like protein 3-interacting protein 1, ZINC ION
著者Shimada, A, Yamaguchi, A, Kohda, D.
登録日2015-07-08
公開日2016-07-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.001 Å)
主引用文献Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 mu homology domain.
Sci Rep, 6, 2016
4CQ1
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BU of 4cq1 by Molmil
Crystal structure of the neuronal isoform of PTB
分子名称: CHLORIDE ION, POLYPYRIMIDINE TRACT-BINDING PROTEIN 2, ZINC ION
著者Joshi, A, Buckroyd, A.N, Curry, S.
登録日2014-02-10
公開日2014-02-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Solution and Crystal Structures of a C Terminal Fragment of the Neuronal Isoform of the Polypyrimidine Tract Binding Protein (Nptb)
Peerj, 2, 2014
5CVS
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BU of 5cvs by Molmil
GlgE isoform 1 from Streptomyces coelicolor E423A mutant soaked in maltoheptaose
分子名称: Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase 1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Rashid, A.M, Syson, K, Koliwer-Brandl, H, van de Weerd, R, Stevenson, C.E.M, Batey, S.F.D, Miah, F, Alber, M, Ioerger, T.R, Chandra, G, Appelmelk, B.J, Nartowski, K.P, Khimyak, Y.Z, Lawson, D.M, Jacobs, W.R, Geurtsen, J, Kalscheuer, R, Bornemann, S.
登録日2015-07-27
公開日2016-08-17
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Ligand-bound structures and site-directed mutagenesis identify the acceptor and secondary binding sites of Streptomyces coelicolor maltosyltransferase GlgE.
J.Biol.Chem., 291, 2016
7TXR
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BU of 7txr by Molmil
Crystal structure of the Vitronectin hemopexin-like domain binding Calcium-2
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, CHLORIDE ION, ...
著者Aleshin, A.E, Marassi, F.M.
登録日2022-02-09
公開日2023-03-29
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for calcium-induced thermostability of human vitronectin
To Be Published
7U68
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Crystal structure of the Vitronectin hemopexin-like domain binding Sodium-2
分子名称: CHLORIDE ION, SODIUM ION, SULFATE ION, ...
著者Aleshin, A.E, Marassi, F.M.
登録日2022-03-03
公開日2023-03-29
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for calcium-induced thermostability of human vitronectin
To Be Published
4E0S
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BU of 4e0s by Molmil
Crystal Structure of C5b-6
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C5, ...
著者Aleshin, A.E, Stec, B, DiScipio, R, Liddington, R.C.
登録日2012-03-05
公開日2012-04-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (4.21 Å)
主引用文献Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex.
J.Biol.Chem., 287, 2012
5AWR
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BU of 5awr by Molmil
Crystal structure of the SGIP1 mu homology domain in the P4212 space group
分子名称: SH3-containing GRB2-like protein 3-interacting protein 1, ZINC ION
著者Shimada, A, Yamaguchi, A, Kohda, D.
登録日2015-07-08
公開日2016-07-06
最終更新日2020-02-26
実験手法X-RAY DIFFRACTION (2.502 Å)
主引用文献Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 mu homology domain.
Sci Rep, 6, 2016
5AWT
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BU of 5awt by Molmil
Crystal structure of the SGIP1 mu homology domain in complex with an Eps15 fragment containing two DPF motifs (YDPFGGDPFKG)
分子名称: Epidermal growth factor receptor substrate 15, SH3-containing GRB2-like protein 3-interacting protein 1, ZINC ION
著者Shimada, A, Yamaguchi, A, Kohda, D.
登録日2015-07-08
公開日2016-07-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.702 Å)
主引用文献Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 mu homology domain.
Sci Rep, 6, 2016
5AWU
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Crystal structure of the SGIP1 mu homology domain in complex with an Eps15 fragment containing two DPF motifs (YDPFKGSDPFA)
分子名称: Epidermal growth factor receptor substrate 15, SH3-containing GRB2-like protein 3-interacting protein 1, ZINC ION
著者Shimada, A, Yamaguchi, A, Kohda, D.
登録日2015-07-08
公開日2016-07-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 mu homology domain.
Sci Rep, 6, 2016
4ORE
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BU of 4ore by Molmil
Cyrstal structure of O-acetylserine sulfhydrylase ternary complex from Haemophilus influenzae at 2.2 A
分子名称: Cysteine synthase, O-ACETYLSERINE, Peptide inhibitor
著者Kaushik, A, Ekka, M.K, Singh, A.K, Kumaran, S.
登録日2014-02-11
公開日2015-02-11
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Cyrstal structure of O-acetylserine sulfhydrylase ternary complex from Haemophilus influenzae at 2.2 A
To be Published
3GLY
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BU of 3gly by Molmil
REFINED CRYSTAL STRUCTURES OF GLUCOAMYLASE FROM ASPERGILLUS AWAMORI VAR. X100
分子名称: GLUCOAMYLASE-471, alpha-D-mannopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Aleshin, A.E, Hoffman, C, Firsov, L.M, Honzatko, R.B.
登録日1994-06-03
公開日1994-11-01
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Refined crystal structures of glucoamylase from Aspergillus awamori var. X100.
J.Mol.Biol., 238, 1994

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