4YUR

Crystal Structure of Plk4 Kinase Domain Bound to Centrinone

Summary for 4YUR

Entry DOI	10.2210/pdb4yur/pdb
Descriptor	Serine/threonine-protein kinase PLK4, 2-({2-fluoro-4-[(2-fluoro-3-nitrobenzyl)sulfonyl]phenyl}sulfanyl)-5-methoxy-N-(3-methyl-1H-pyrazol-5-yl)-6-(morpholin-4-yl)pyrimidin-4-amine (3 entities in total)
Functional Keywords	transferase, protein kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole: O00444
Total number of polymer chains	1
Total formula weight	32269.21
Authors	Shiau, A.K.,Motamedi, A. (deposition date: 2015-03-19, release date: 2015-06-17, Last modification date: 2023-09-27)
Primary citation	Wong, Y.L.,Anzola, J.V.,Davis, R.L.,Yoon, M.,Motamedi, A.,Kroll, A.,Seo, C.P.,Hsia, J.E.,Kim, S.K.,Mitchell, J.W.,Mitchell, B.J.,Desai, A.,Gahman, T.C.,Shiau, A.K.,Oegema, K. Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science, 348:1155-1160, 2015 Cited by PubMed: 25931445 DOI: 10.1126/science.aaa5111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation