4YUR
Crystal Structure of Plk4 Kinase Domain Bound to Centrinone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase PLK4 | polymer | 278 | 31635.6 | 1 | UniProt (O00444) Pfam (PF00069) | Homo sapiens (Human) | Polo-like kinase 4,PLK-4,Serine/threonine-protein kinase 18,Serine/threonine-protein kinase Sak |
| 2 | B (A) | 2-({2-fluoro-4-[(2-fluoro-3-nitrobenzyl)sulfonyl]phenyl}sulfanyl)-5-methoxy-N-(3-methyl-1H-pyrazol-5-yl)-6-(morpholin-4-yl)pyrimidin-4-amine | non-polymer | 633.6 | 1 | Chemie (4J7) | |||
| 3 | C (A) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A: 2 - 275 (UniProt: O00444)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31635.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 633.6 | |
| All* | Total formula weight | 32269.2 |
