4Z7H

Crystal structure of human IRE1 cytoplasmic kinase-RNase region - complex with imidazopyridine compound 3

Summary for 4Z7H

• Entry DOI: 10.2210/pdb4z7h/pdb
• Descriptor: Serine/threonine-protein kinase/endoribonuclease IRE1, 2-methoxy-4-[6-(propan-2-ylamino)imidazo[1,2-b]pyridazin-3-yl]benzamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: transferase, kinase, rnase, unfolded protein response
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 96258.43

Authors

Joshi, A.,Bayliss, R. (deposition date: 2015-04-07, release date: 2015-05-27, Last modification date: 2024-01-10)

• Primary citation: Joshi, A.,Newbatt, Y.,McAndrew, P.C.,Stubbs, M.,Burke, R.,Richards, M.W.,Bhatia, C.,Caldwell, J.J.,McHardy, T.,Collins, I.,Bayliss, R.; Molecular mechanisms of human IRE1 activation through dimerization and ligand binding.; Oncotarget, 6:13019-13035, 2015; PubMed: 25968568; DOI: 10.18632/oncotarget.3864

Experimental method

X-RAY DIFFRACTION (2.9 Å)