3O9G
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![BU of 3o9g by Molmil](/molmil-images/mine/3o9g) | Crystal Structure of wild-type HIV-1 Protease in complex with af53 | 分子名称: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(1S,2R)-1-benzyl-3-[(2-ethylbutyl){[4-(hydroxymethyl)phenyl]sulfonyl}amino]-2-hydroxypropyl}carbamate, PHOSPHATE ION, Protease | 著者 | Schiffer, C.A, Nalam, M.N.L. | 登録日 | 2010-08-04 | 公開日 | 2011-08-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. Chem.Biol., 20, 2013
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4DJO
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![BU of 4djo by Molmil](/molmil-images/mine/4djo) | Crystal Structure of wild-type HIV-1 Protease in Complex with MKP56 | 分子名称: | 2-[(dichloroacetyl)amino]ethyl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-phenylbutan-2-yl]carbamate, ACETATE ION, GLYCEROL, ... | 著者 | Schiffer, C.A, Nalam, M.N.L. | 登録日 | 2012-02-02 | 公開日 | 2012-08-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance. J.Med.Chem., 55, 2012
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3O9H
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![BU of 3o9h by Molmil](/molmil-images/mine/3o9h) | Crystal Structure of wild-type HIV-1 Protease in complex with kd26 | 分子名称: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(2-ethylbutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate, ACETATE ION, PHOSPHATE ION, ... | 著者 | Schiffer, C.A, Nalam, M.N.L. | 登録日 | 2010-08-04 | 公開日 | 2011-08-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. Chem.Biol., 20, 2013
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3O9A
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![BU of 3o9a by Molmil](/molmil-images/mine/3o9a) | Crystal Structure of wild-type HIV-1 Protease in complex with kd14 | 分子名称: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino}propyl]carbamate, PHOSPHATE ION, Pol polyprotein | 著者 | Schiffer, C.A, Nalam, M.N.L. | 登録日 | 2010-08-04 | 公開日 | 2011-08-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. Chem.Biol., 20, 2013
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3OY4
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![BU of 3oy4 by Molmil](/molmil-images/mine/3oy4) | Crystal Structure of HIV-1 L76V Protease in Complex with the Protease Inhibitor Darunavir. | 分子名称: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ACETATE ION, HIV-1 PROTEASE, ... | 著者 | Schiffer, C.A, Nalivaika, E.A, Bandaranayake, R.M. | 登録日 | 2010-09-22 | 公開日 | 2011-02-09 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Crystal Structure of HIV-1 L76V Protease in Complex with the Protease Inhibitor Darunavir. To be Published
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3R4B
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![BU of 3r4b by Molmil](/molmil-images/mine/3r4b) | Crystal Structure of Wild-type HIV-1 Protease in Complex With TMC310911 | 分子名称: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-4-[({2-[(1-cyclopentylpiperidin-4-yl)amino]-1,3-benzothiazol-6-yl}sulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-p henylbutan-2-yl}carbamate, HIV-1 protease, PHOSPHATE ION | 著者 | Schiffer, C.A, Nalam, M.N.L. | 登録日 | 2011-03-17 | 公開日 | 2011-09-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors. Antimicrob.Agents Chemother., 55, 2011
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3O99
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![BU of 3o99 by Molmil](/molmil-images/mine/3o99) | Crystal Structure of wild-type HIV-1 Protease in complex with kd13 | 分子名称: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate, ACETATE ION, PHOSPHATE ION, ... | 著者 | Schiffer, C.A, Nalam, M.N.L. | 登録日 | 2010-08-04 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. Chem.Biol., 20, 2013
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3O9D
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![BU of 3o9d by Molmil](/molmil-images/mine/3o9d) | Crystal Structure of wild-type HIV-1 Protease in complex with kd19 | 分子名称: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate, ACETATE ION, PHOSPHATE ION, ... | 著者 | Schiffer, C.A, Nalam, M.N.L. | 登録日 | 2010-08-04 | 公開日 | 2011-08-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. Chem.Biol., 20, 2013
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4EP2
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![BU of 4ep2 by Molmil](/molmil-images/mine/4ep2) | Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate RT-RH | 分子名称: | GLYCEROL, PHOSPHATE ION, protease, ... | 著者 | Schiffer, C.A, Mittal, S. | 登録日 | 2012-04-16 | 公開日 | 2012-06-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease. Protein Sci., 21, 2012
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4EP3
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![BU of 4ep3 by Molmil](/molmil-images/mine/4ep3) | Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate CA-p2 | 分子名称: | BETA-MERCAPTOETHANOL, GLYCEROL, protease, ... | 著者 | Schiffer, C.A, Mittal, S. | 登録日 | 2012-04-16 | 公開日 | 2012-06-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease. Protein Sci., 21, 2012
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4EQ0
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![BU of 4eq0 by Molmil](/molmil-images/mine/4eq0) | Crystal Structure of inactive single chain variant of HIV-1 Protease in Complex with the substrate p2-NC | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, BETA-MERCAPTOETHANOL, ... | 著者 | Schiffer, C.A, Mittal, S. | 登録日 | 2012-04-17 | 公開日 | 2012-06-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease. Protein Sci., 21, 2012
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4EPJ
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![BU of 4epj by Molmil](/molmil-images/mine/4epj) | Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate p2-NC | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, BETA-MERCAPTOETHANOL, ... | 著者 | Schiffer, C.A, Mittal, S. | 登録日 | 2012-04-17 | 公開日 | 2012-06-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease. Protein Sci., 21, 2012
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3SAB
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![BU of 3sab by Molmil](/molmil-images/mine/3sab) | |
3SA8
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![BU of 3sa8 by Molmil](/molmil-images/mine/3sa8) | |
3SA9
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![BU of 3sa9 by Molmil](/molmil-images/mine/3sa9) | |
3SA6
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![BU of 3sa6 by Molmil](/molmil-images/mine/3sa6) | Crystal structure of wild-type HIV-1 protease in complex with AF71 | 分子名称: | 3-hydroxy-N-[(2S,3R)-3-hydroxy-4-([(2S)-2-methylbutyl]{[5-(1,2-oxazol-5-yl)thiophen-2-yl]sulfonyl}amino)-1-phenylbutan-2-yl]benzamide, PHOSPHATE ION, Protease | 著者 | Schiffer, C.A, Nalam, M.N.L. | 登録日 | 2011-06-02 | 公開日 | 2012-06-06 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Protease Inhibitors that protrude out from substrate envelope are more susceptible to developing drug resistance To be Published
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3SA3
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![BU of 3sa3 by Molmil](/molmil-images/mine/3sa3) | Crystal structure of wild-type HIV-1 protease in complex with AG23 | 分子名称: | ACETATE ION, N~2~-acetyl-N-[(2S,3R)-4-{(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino}-3-hydroxy-1-phenylbutan-2-yl]-L-isoleucinamide, PHOSPHATE ION, ... | 著者 | Schiffer, C.A, Nalam, M.N.L. | 登録日 | 2011-06-02 | 公開日 | 2012-06-06 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Protease Inhibitors that protrude out from substrate envelope are more susceptible to developing drug resistance To be Published
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3SAA
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![BU of 3saa by Molmil](/molmil-images/mine/3saa) | |
3SA4
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![BU of 3sa4 by Molmil](/molmil-images/mine/3sa4) | |
3SAC
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![BU of 3sac by Molmil](/molmil-images/mine/3sac) | |
3SA7
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![BU of 3sa7 by Molmil](/molmil-images/mine/3sa7) | |
6CVX
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![BU of 6cvx by Molmil](/molmil-images/mine/6cvx) | |
6CVY
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![BU of 6cvy by Molmil](/molmil-images/mine/6cvy) | |
1T7J
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![BU of 1t7j by Molmil](/molmil-images/mine/1t7j) | crystal structure of inhibitor amprenavir in complex with a multi-drug resistant variant of HIV-1 protease (L63P/V82T/I84V) | 分子名称: | ACETATE ION, Pol Polyprotein, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | 著者 | King, N.M, Prabu-Jeyabalan, M, Nalivaika, E.A, Wigerinck, P.B.T.P, De Bethune, M.-P, Schiffer, C.A. | 登録日 | 2004-05-10 | 公開日 | 2005-05-10 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor J.Med.Chem., 48, 2005
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8FL5
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![BU of 8fl5 by Molmil](/molmil-images/mine/8fl5) | |