4EPJ

Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate p2-NC

Summary for 4EPJ

• Entry DOI: 10.2210/pdb4epj/pdb
• Related: 4EP2 4EP3 4EQ0 4EQJ
• Descriptor: protease, tethered dimer, substrate p2-NC, GLYCEROL, ... (8 entities in total)
• Functional Keywords: hiv-1 protease, specificity design, drug design, protease inhibitors, aids, aspartyl protease, hydrolase, hydrolase-hydrolase substrate complex, hydrolase/hydrolase substrate
• Biological source: HIV-1 M:B_ARV2/SF2 (HIV-1); More
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369; Host cytoplasm . Host nucleus . Matrix protein p17: Virion . Virion : Q9YP46
• Total number of polymer chains: 2
• Total formula weight: 23374.69

Authors

Schiffer, C.A.,Mittal, S. (deposition date: 2012-04-17, release date: 2012-06-06, Last modification date: 2024-02-28)

• Primary citation: Alvizo, O.,Mittal, S.,Mayo, S.L.,Schiffer, C.A.; Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease.; Protein Sci., 21:1029-1041, 2012; PubMed: 22549928; DOI: 10.1002/pro.2086

Experimental method

X-RAY DIFFRACTION (1.69 Å)