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3SA6

Crystal structure of wild-type HIV-1 protease in complex with AF71

Summary for 3SA6
Entry DOI10.2210/pdb3sa6/pdb
Related3SA3 3SA4 3SA5 3SA7 3SA8 3SA9 3SAA 3SAB 3SAC
Related PRD IDPRD_000949
DescriptorProtease, PHOSPHATE ION, 3-hydroxy-N-[(2S,3R)-3-hydroxy-4-([(2S)-2-methylbutyl]{[5-(1,2-oxazol-5-yl)thiophen-2-yl]sulfonyl}amino)-1-phenylbutan-2-yl]benzamide, ... (4 entities in total)
Functional Keywordshiv-1 protease, drug resistance, drug design, protease inhibitors, aids, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22405.24
Authors
Schiffer, C.A.,Nalam, M.N.L. (deposition date: 2011-06-02, release date: 2012-06-06, Last modification date: 2023-09-13)
Primary citationAltman, M.D.,Nalam, M.N.L.,Ali, A.,Cao, H.,Rana, T.M.,Schiffer, C.A.,Tidor, B.
Protease Inhibitors that protrude out from substrate envelope are more susceptible to developing drug resistance
To be Published,
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

229380

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