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3SAA

Crystal structure of Wild-type HIV-1 protease in complex With AF77

Summary for 3SAA
Entry DOI10.2210/pdb3saa/pdb
Related3SA3 3SA4 3SA5 3SA6 3SA7 3SA8 3SA9 3SAB 3SAC
Related PRD IDPRD_000953
DescriptorProtease, PHOSPHATE ION, N-[(2S,3R)-4-{(cyclohexylmethyl)[(4-methoxyphenyl)sulfonyl]amino}-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamide, ... (4 entities in total)
Functional Keywordshiv-1 protease, drug resistance, drug design, protease inhibitors, aids, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22388.23
Authors
Schiffer, C.A.,Nalam, M.N.L. (deposition date: 2011-06-02, release date: 2012-06-06, Last modification date: 2023-09-13)
Primary citationAltman, M.D.,Nalam, M.N.L.,Ali, A.,Cao, H.,Rana, T.M.,Schiffer, C.A.,Tidor, B.
Protease Inhibitors that protrude out from substrate envelope are more susceptible to developing drug resistance
To be Published,
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

227561

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